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    CANCER STEM CELL MASS AND PROCESS FOR PRODUCTION THEREOF
    2.
    发明申请
    CANCER STEM CELL MASS AND PROCESS FOR PRODUCTION THEREOF 审中-公开
    癌症干细胞质量及其生产方法

    公开(公告)号：US20130288248A1

    公开(公告)日：2013-10-31

    申请号：US13878181

    申请日：2011-10-06

    申请人： Tatsumi Yamazaki ,  Hisafumi Okabe ,  Shinta Kobayashi ,  Yu Jau Chen ,  Atsuhiko Kato ,  Masami Suzuki ,  Koichi Matsubara

    发明人： Tatsumi Yamazaki ,  Hisafumi Okabe ,  Shinta Kobayashi ,  Yu Jau Chen ,  Atsuhiko Kato ,  Masami Suzuki ,  Koichi Matsubara

    IPC分类号： C12N5/095

    CPC分类号： C12N5/0695 ,  G01N33/5011 ,  G01N33/5073

    摘要： The purpose of the present invention is to provide: a cancer stem cell mass from which cells incapable of forming cancer are substantially removed and which has a characteristic property of reproducing a layered structure of a cancer tissue; a process for producing the cancer stem cell mass; and use of the cancer stem cell mass. For achieving the purpose, the present inventors grew a human cancer tissue repeatedly in a NOG mouse, separated cancer cells from the grown cancer tissue, and made a comparison of various cancer cell culture processes with each other. As a result, a cancer stem cell composition which is homogeneous and is substantially free of the coexistence of cells capable of forming cancer and cells incapable of forming cancer in a mixed state can be produced successively by employing an attached culture process using a serum-free stem cell culture medium rather than a generally employed floating culture process, and consequently the present invention has been accomplished.

    摘要翻译： 本发明的目的是提供：基本上除去不能形成癌症的细胞的癌干细胞群，其具有再现癌组织的层状结构的特征; 一种生产癌症干细胞团的方法; 并使用癌干细胞团。 为了达到上述目的，本发明人在NOG小鼠中反复生长人类癌组织，从生长的癌组织中分离癌细胞，并进行各种癌细胞培养方法的比较。 结果，可以通过使用不含血清的附着培养方法，连续地制备均质且基本上不含可形成癌细胞的细胞和不能混合形成癌症的细胞的癌干细胞组合物 干细胞培养基而不是通常使用的浮动培养方法，因此本发明已经实现。

    Reshaped human antibody to human interleukin-8
    5.
    发明授权
    Reshaped human antibody to human interleukin-8 有权
    重组人抗人白介素-8抗体

    公开(公告)号：US06245894B1

    公开(公告)日：2001-06-12

    申请号：US09416557

    申请日：1999-10-12

    申请人： Kouji Matsushima ,  Yoshihiro Matsumoto ,  Yoshiki Yamada ,  Koh Sato ,  Masayuki Tsuchiya ,  Tatsumi Yamazaki

    发明人： Kouji Matsushima ,  Yoshihiro Matsumoto ,  Yoshiki Yamada ,  Koh Sato ,  Masayuki Tsuchiya ,  Tatsumi Yamazaki

    IPC分类号： C07K1400

    CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00

    摘要： A reshaped human antibody is characterized as having the same binding affinity for IL-8 as a chimeric antibody but with low immunogenicity in comparison. The reshaped antibody has the following elements: a human L chain C region or a human L chain FR and an L chain CDR from a mouse monoclonal antibody against human IL-8 and a human H chain C region or a human H chain FR and an H chain CDR of mouse monoclonal antibody against human IL-8. Since the reshaped human antibody has low immunogenicity to humans, it is suitable for use in medical treatment of a variety of medical conditions.

    摘要翻译： 重整的人抗体的特征在于具有与嵌合抗体相同的IL-8的结合亲和力，但相比之下具有低的免疫原性。 重构抗体具有以下元件：来自针对人IL-8和人H链C区或人H链FR的小鼠单克隆抗体的人L链C区或人L链FR和L链CDR， 小鼠单克隆抗体针对人IL-8的H链CDR。 由于重整人抗体对人的免疫原性低，因此适用于各种医疗条件的医疗。

    Polynucleotides which encode reshaped IL-8-specific antibodies and methods to produce the same
    8.
    发明授权
    Polynucleotides which encode reshaped IL-8-specific antibodies and methods to produce the same 失效
    编码重组的IL-8特异性抗体的多核苷酸及其制备方法

    公开(公告)号：US5994524A

    公开(公告)日：1999-11-30

    申请号：US765783

    申请日：1997-03-07

    申请人： Kouji Matsushima ,  Yoshihiro Matsumoto ,  Yoshiki Yamada ,  Koh Sato ,  Masayuki Tsuchiya ,  Tatsumi Yamazaki

    发明人： Kouji Matsushima ,  Yoshihiro Matsumoto ,  Yoshiki Yamada ,  Koh Sato ,  Masayuki Tsuchiya ,  Tatsumi Yamazaki

    IPC分类号： C07K16/24 ,  C12N15/13 ,  C12P21/08 ,  C07H21/04 ,  C12N5/10

    CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00

    摘要： The present invention discloses a reshaped human antibody against human IL-8 comprising:(A) L chains each comprising:(1) a human L chain C region; and,(2) an L chain V region comprising a human Lchain FR, and an L chain CDR of mouse monoclonal antibody against human IL-8; and,(B) H chains each comprising:(1) a human H chain C region; and,(2) an H chain V region comprising a human Hchain FR, and an H chain CDR of mouse monoclonal antibody against human IL-8. Since the majority of this reshaped human antibody originates in human antibody and the CDR has low antigenicity, the reshaped human antibody of the present invention has low antigenicity to humans, and can therefore be expected to be useful in medical treatment. The present invention further discloses polynucleotides which encode reshaped antibodies against IL-8, as well as host cells and methods to produce these antibodies.

    摘要翻译： PCT No.PCT / JP95 / 01396 Sec。 371日期1997年3月7日 102（e）1997年3月7日PCT PCT 1995年7月12日PCT公布。 出版物WO97 / 02576 日本1996年2月1日本发明公开了针对人IL-8的重构人抗体，其包含：（A）L链，各自包含：（1）人L链C区; 和（2）包含人L链FR的L链V区和针对人IL-8的小鼠单克隆抗体的L链CDR; 和（B）H链，其各自包含：（1）人H链C区; 和（2）包含人H链FR的H链V区和针对人IL-8的小鼠单克隆抗体的H链CDR。 由于这种重整人抗体的大部分源于人抗体，CDR具有低抗原性，所以本发明的重构人抗体对人的抗原性低，因此可以预期可用于治疗。 本发明进一步公开了编码针对IL-8的重整抗体以及宿主细胞的多核苷酸以及产生这些抗体的方法。