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公开(公告)号：US20070037788A1
公开(公告)日：2007-02-15
申请号：US10576761
申请日：2004-12-08
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4184 , A61K31/454 , C07D413/14 , C07D405/14 , C07D403/14
CPC分类号： C07D235/26 , C07D405/06 , C07D405/14
摘要： The present invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart disease, hypertension, rheumatoid arthritis or inflammation, comprising administering to a patient in thereof an effective amount of a compound of Formula (I).
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐; 药物组合物包含有效量的式（I）化合物与合适的载体，稀释剂或赋形剂的组合; 以及用于治疗生理障碍，特别是充血性心脏病，高血压，类风湿性关节炎或炎症的方法，包括向其中的患者施用有效量的式（I）化合物。
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公开(公告)号：US20070088016A1
公开(公告)日：2007-04-19
申请号：US10576901
申请日：2004-12-15
IPC分类号： A61K31/5377 , A61K31/452 , A61K31/496 , A61K31/453 , A61K31/4178 , A61K31/397 , A61K31/4025 , C07D409/02 , C07D405/02
CPC分类号： C07C39/23 , C07C43/215 , C07C43/23 , C07D311/84 , C07D311/90 , C07D335/12 , C07D335/20 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06
摘要： The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart disease, hypertension, rheumatoid arthritis or inflammation, comprising administering to a patient in thereof an effective amount of a compound of Formula (I).
摘要翻译： 本发明提供式（I）的化合物或其药学上可接受的盐; 包含有效量的式I化合物与合适的载体，稀释剂或赋形剂组合的药物组合物; 以及用于治疗生理障碍，特别是充血性心脏病，高血压，类风湿性关节炎或炎症的方法，包括向其中的患者施用有效量的式（I）化合物。
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公开(公告)号：US20060235222A1
公开(公告)日：2006-10-19
申请号：US10542621
申请日：2004-01-20
申请人： Michael Bell , Konstantinos Gavardinas , Douglas Gernert , Timothy Grese , Prabhakar Jadhav , Peter Lander , Mitchell Steinberg
发明人： Michael Bell , Konstantinos Gavardinas , Douglas Gernert , Timothy Grese , Prabhakar Jadhav , Peter Lander , Mitchell Steinberg
IPC分类号： A61K31/506 , C07D413/02 , C07D417/02 , C07D409/02 , C07D405/02 , C07D403/02
CPC分类号： C07D401/06 , C07D209/08 , C07D209/10 , C07D333/56 , C07D333/68 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D491/04 , C07F5/003 , C07F5/069 , C07F7/0836
摘要： The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.
摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，药物组合物，其包含有效量的式I化合物与合适的载体，稀释剂或赋形剂的组合，以及用于治疗生理障碍，特别是充血性心脏的方法 包括向其中的患者施用有效量的式I化合物。
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4.发明申请Bicyclic substituted indole-derivative steroid hormone nuclear receptor modulators 失效双环取代的吲哚衍生物类固醇激素核受体调节剂公开(公告)号：US20070185161A1
公开(公告)日：2007-08-09
申请号：US10598330
申请日：2005-02-18
IPC分类号： A61K31/4709 , C07D403/04 , C07D405/04 , C07D409/04 , A61K31/405
CPC分类号： C07D209/08 , C07D209/10 , C07D209/12 , C07D209/14 , C07D403/10 , C07D405/04 , C07D409/04
摘要： The present invention provides a compound of the formula: Formula (I); or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, hypertension, and atherosclerosis, comprising administering to a patient in thereof an effective amount of a compound of Formula I. X-16125
摘要翻译： 本发明提供下式的化合物：式（I）; 其药物组合物包含有效量的式I化合物与合适的载体，稀释剂或赋形剂的组合，以及用于治疗生理障碍，特别是充血性心脏病，高血压和动脉粥样硬化的方法，包括施用 对其中的患者有效量的式I化合物。X-16125
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5.发明申请Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators 失效二氢吲哚-2-酮衍生物作为类固醇激素核受体调节剂公开(公告)号：US20050054712A1
公开(公告)日：2005-03-10
申请号：US10506175
申请日：2003-03-11
IPC分类号： A61P7/10 , A61P9/12 , C07D209/34 , C07D401/04 , C07D401/06 , C07D403/04 , C07D413/06 , C07D417/06 , A61K31/404
CPC分类号： C07D401/04 , C07D209/34 , C07D401/06 , C07D403/04 , C07D413/06 , C07D417/06
摘要： he present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation, particularly congestive heart failure, comprising administering to a patient in need thereof an effective amount of a compound of the formula: I or a pharmaceutically acceptable salt thereof. In addition, the present invention provides novel pharmaceutical compounds of Formula I, including the pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions which comprise as an active ingredient a compound of Formula I.
摘要翻译： 本发明涉及治疗对类固醇激素核受体调节敏感的病理学障碍，特别是充血性心力衰竭的方法，其包括向有需要的患者施用有效量的式I化合物或其药学上可接受的盐。 此外，本发明提供了新颖的式I的药物化合物，包括其药学上可接受的盐，以及包含式I化合物作为活性成分的药物组合物。
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公开(公告)号：US20070112036A1
公开(公告)日：2007-05-17
申请号：US10581178
申请日：2004-12-15
申请人： Marta De La Torre , Nuria Diaz Buezo , Prabhakar Jadhav , Charles Mitch , Concepcion Pedregal-Tercero
发明人： Marta De La Torre , Nuria Diaz Buezo , Prabhakar Jadhav , Charles Mitch , Concepcion Pedregal-Tercero
IPC分类号： A61K31/4439 , A61K31/44 , C07D403/04 , C07D213/62
CPC分类号： C07D213/78 , C07D213/80 , C07D213/82 , C07D231/56 , C07D261/20 , C07D401/04 , C07D409/14 , C07D413/12 , C07D413/14
摘要： A compound of the formula (I); wherein the variables X1 to X10, R1 to R7 including R3′, E, W, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed.
摘要翻译： 式（I）化合物; 其中X 1至X 10，R 1至R 7的变量X 1至R 7包括R 3' / SUP>，E，W，v，y，z，A和B如上所述，或其药学上可接受的盐，溶剂化物，对映异构体，外消旋物，非对映异构体或其混合物，可用于治疗，预防或改善肥胖症和相关 疾病被公开。
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