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公开(公告)号：US20060235222A1
公开(公告)日：2006-10-19
申请号：US10542621
申请日：2004-01-20
申请人： Michael Bell , Konstantinos Gavardinas , Douglas Gernert , Timothy Grese , Prabhakar Jadhav , Peter Lander , Mitchell Steinberg
发明人： Michael Bell , Konstantinos Gavardinas , Douglas Gernert , Timothy Grese , Prabhakar Jadhav , Peter Lander , Mitchell Steinberg
IPC分类号： A61K31/506 , C07D413/02 , C07D417/02 , C07D409/02 , C07D405/02 , C07D403/02
CPC分类号： C07D401/06 , C07D209/08 , C07D209/10 , C07D333/56 , C07D333/68 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D491/04 , C07F5/003 , C07F5/069 , C07F7/0836
摘要： The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.
摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，药物组合物，其包含有效量的式I化合物与合适的载体，稀释剂或赋形剂的组合，以及用于治疗生理障碍，特别是充血性心脏的方法 包括向其中的患者施用有效量的式I化合物。
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2.发明申请Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators 失效二氢吲哚-2-酮衍生物作为类固醇激素核受体调节剂公开(公告)号：US20050054712A1
公开(公告)日：2005-03-10
申请号：US10506175
申请日：2003-03-11
IPC分类号： A61P7/10 , A61P9/12 , C07D209/34 , C07D401/04 , C07D401/06 , C07D403/04 , C07D413/06 , C07D417/06 , A61K31/404
CPC分类号： C07D401/04 , C07D209/34 , C07D401/06 , C07D403/04 , C07D413/06 , C07D417/06
摘要： he present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation, particularly congestive heart failure, comprising administering to a patient in need thereof an effective amount of a compound of the formula: I or a pharmaceutically acceptable salt thereof. In addition, the present invention provides novel pharmaceutical compounds of Formula I, including the pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions which comprise as an active ingredient a compound of Formula I.
摘要翻译： 本发明涉及治疗对类固醇激素核受体调节敏感的病理学障碍，特别是充血性心力衰竭的方法，其包括向有需要的患者施用有效量的式I化合物或其药学上可接受的盐。 此外，本发明提供了新颖的式I的药物化合物，包括其药学上可接受的盐，以及包含式I化合物作为活性成分的药物组合物。
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公开(公告)号：US20060063759A1
公开(公告)日：2006-03-23
申请号：US10517010
申请日：2003-06-13
申请人： Michael Coghlan , Jonathan Green , Timothy Grese , Prabhakar Kondaji , Doanald Matthews , Mitchell Steinberg , Kevin Fales , Michael Bell
发明人： Michael Coghlan , Jonathan Green , Timothy Grese , Prabhakar Kondaji , Doanald Matthews , Mitchell Steinberg , Kevin Fales , Michael Bell
IPC分类号： A61K31/551 , A61K31/473
CPC分类号： C07D213/16 , C07C22/04 , C07C22/08 , C07C25/24 , C07C33/38 , C07C39/17 , C07C39/23 , C07C39/42 , C07C43/215 , C07C43/225 , C07C43/23 , C07C47/548 , C07C47/57 , C07C49/835 , C07C69/00 , C07C69/618 , C07C69/65 , C07C205/06 , C07C205/34 , C07C205/35 , C07C211/28 , C07C211/32 , C07C211/45 , C07C215/76 , C07C217/84 , C07C233/07 , C07C233/65 , C07C233/84 , C07C235/16 , C07C251/40 , C07C251/48 , C07C255/50 , C07C261/04 , C07C271/14 , C07C275/28 , C07C307/10 , C07C311/03 , C07C311/08 , C07C311/09 , C07C311/16 , C07C311/20 , C07C311/21 , C07C311/29 , C07C317/14 , C07C317/32 , C07C321/28 , C07C323/49 , C07C2601/02 , C07C2603/32 , C07C2603/40 , C07C2603/78 , C07C2603/86 , C07D209/08 , C07D209/34 , C07D211/96 , C07D213/06 , C07D213/73 , C07D213/76 , C07D213/81 , C07D221/16 , C07D223/20 , C07D231/12 , C07D231/18 , C07D233/26 , C07D233/68 , C07D233/84 , C07D235/26 , C07D241/12 , C07D241/20 , C07D261/08 , C07D261/10 , C07D263/52 , C07D263/56 , C07D263/58 , C07D277/60 , C07D295/088 , C07D295/26 , C07D313/12 , C07D333/78 , C07D333/80 , C07D337/12 , C07D401/06 , C07D405/06 , C07D409/04 , C07D471/04 , C07D471/06 , C07D487/04 , C07D491/044
摘要： The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula (I): or a pharmaceutically acceptable salt thereof. In addition, the present invention provides novel pharmaceutical compounds of Formula (I), including the pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions which comprise as an active ingredient a compound of Formula (I).
摘要翻译： 本发明涉及治疗对类固醇激素核受体调节敏感的病理学障碍的方法，包括向有需要的患者施用有效量的式（I）化合物或其药学上可接受的盐。 此外，本发明提供新的式（I）的药物化合物，包括其药学上可接受的盐，以及包含作为活性成分的式（I）的化合物的药物组合物。
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公开(公告)号：US06523179B1
公开(公告)日：2003-02-25
申请号：US09929541
申请日：2001-08-13
IPC分类号： A42B100
摘要： A tissue face mask similar to that used by a dentist but placed in covering relation over the face of a patient preparatory to a dental procedure using a laser or similar light-emitting device in which mask there are shaping stays that are manually conformed to the facial features of the patient to prevent harm to the patient from the emitted light of the dental procedure.
摘要翻译： 类似于牙科医生使用的组织面罩，其使用激光或类似的发光装置在患者的牙齿手术准备的患者的脸上放置成覆盖关系，其中具有手动符合面部的成形支架 患者的特征，以防止从牙科手术的发射光对患者的伤害。
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公开(公告)号：US20110229372A2
公开(公告)日：2011-09-22
申请号：US12351427
申请日：2009-01-09
CPC分类号： A61L2/28 , A61B50/30 , A61B2050/314 , A61L2/07 , A61L2/206 , B31B50/62 , B31B50/74 , B31B50/88 , B65D33/004 , B65D33/20 , B65D2203/12
摘要： A sterilizable pouch having both internal and external sterilization record indicators to indicate whether attempted steam sterilization of the pouch and contents was successful or unsuccessful. The pouch preferably has one indicium in each indicator responsive to multi-parameter sterilization by steam, and another indicium in each indicator responsive to gas sterilization, such as using ethylene oxide.
摘要翻译： 具有内部和外部灭菌记录指示器的可灭菌袋，用于指示试图对袋和内容物进行蒸汽灭菌是否成功或不成功。 每个指示剂中的袋子优选地具有响应于通过蒸汽的多参数灭菌的一个标记，以及响应于气体灭菌的每个指示器中的另一个标记，例如使用环氧乙烷。
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公开(公告)号：US20050094308A1
公开(公告)日：2005-05-05
申请号：US10942678
申请日：2004-09-15
CPC分类号： G11B5/584
摘要： The present invention provides servo systems and accompanying methods for determining the relative position of a transducer head to a magnetic storage tape utilizing the position of the magnetic storage tape edge. In one example, a method for positioning a transducer head relative to a magnetic storage medium includes optically sensing a position of an edge of the storage medium, and repositioning the transducer head relative to the storage medium based on the read signal and the position of the edge of the storage medium.
摘要翻译： 本发明提供了伺服系统和伴随的方法，用于利用磁存储带边缘的位置确定换能器头与磁存储带的相对位置。 在一个示例中，用于相对于磁存储介质定位换能器头的方法包括光学地感测存储介质的边缘的位置，并且基于读取信号和相对于存储介质的位置来重新定位换能器头相对于存储介质 存储介质的边缘。
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7.发明申请Servo methods and systems using existing data structures and medium edge position 有权使用现有数据结构和中等边缘位置的伺服方法和系统公开(公告)号：US20050083602A1
公开(公告)日：2005-04-21
申请号：US10942658
申请日：2004-09-15
CPC分类号： G11B5/584
摘要： The present invention provides servo systems and accompanying methods for determining the relative position of a transducer head to a magnetic storage tape utilizing existing data structures on the magnetic storage tape and the position of the tape edge. In one example, a method for positioning a transducer head relative to a magnetic storage medium includes sensing a read signal from a read element associated with a transducer head, the read signal in response to a reference data track stored on a magnetic storage medium, optically sensing a position of an edge of the storage medium, and repositioning the transducer head relative to the storage medium in response to the read signal and the position of the edge of the storage medium.
摘要翻译： 本发明提供了伺服系统和相关方法，用于利用磁存储带上的现有数据结构和磁带边缘的位置确定换能器头与磁存储磁带的相对位置。 在一个示例中，用于相对于磁存储介质定位换能器头的方法包括：检测来自与换能器头相关联的读取元件的读取信号，该读取信号响应于存储在磁性存储介质上的参考数据轨迹，光学地 感测存储介质的边缘的位置，以及响应于读取信号和存储介质的边缘的位置，相对于存储介质重新定位换能器头。
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公开(公告)号：US06185740B1
公开(公告)日：2001-02-13
申请号：US09603861
申请日：2000-06-26
IPC分类号： A42B100
CPC分类号： A61C3/025 , A41D13/1184 , A61B46/00 , A61C5/90 , A61F9/045
摘要： A tissue face mask similar to that used by a dentist but placed in covering relation over the face of a patient preparatory to an abrasive dental procedure in which mask there are shaping stays that are manually conformed to the facial features of the patient to prevent harm to the patient from the particulate fall out of the abrasive dental procedure.
摘要翻译： 一种组织面罩，其类似于牙科医生使用的组织面罩，但是覆盖在患者的面上的覆盖关系，所述患者准备用于研磨性牙科手术，其中具有手术符合患者面部特征的成形支架的面罩，以防止对患者的伤害 来自颗粒的患者从研磨牙科手术中脱落。
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9.发明申请公开(公告)号：US20050083601A1
公开(公告)日：2005-04-21
申请号：US10929039
申请日：2004-08-27
CPC分类号： G11B5/584
摘要： In one example, a method is provided for detecting the relative position of a transducer head with respect to a storage medium utilizing existing or previously written data structures on a magnetic storage tape and optically diffractive media. The method includes generating a read signal from a read element associated with a transducer head, the read signal generated from a reference data track stored on a magnetic storage medium, and determining a relative position of a first diffractive medium with respect to a second diffractive medium, wherein the first diffractive medium is associated with the storage medium. The transducer head is repositioned relative to the storage medium in response to the read signal and the relative position of the first diffractive medium and the second diffractive medium.
摘要翻译： 在一个示例中，提供了一种用于利用磁存储带和光学衍射介质上的现有或预先写入的数据结构来检测换能器头相对于存储介质的相对位置的方法。 该方法包括从与换能器头相关联的读取元件产生读取信号，从存储在磁性存储介质上的参考数据轨道产生的读取信号，以及确定第一衍射介质相对于第二衍射介质的相对位置 其中所述第一衍射介质与所述存储介质相关联。 响应于读取信号和第一衍射介质和第二衍射介质的相对位置，换能器头相对于存储介质重新定位。
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公开(公告)号：US20050083600A1
公开(公告)日：2005-04-21
申请号：US10928229
申请日：2004-08-27
CPC分类号： G11B5/2652 , G11B5/00 , G11B5/00813 , G11B5/488 , G11B5/4893 , G11B5/4969 , G11B5/584 , G11B20/1205 , G11B2005/001
摘要： According to one aspect, methods and systems for determining the position of a recording head using existing data structures on magnetic storage media are provided. In one example, a recording head writes data to an active track on a magnetic storage tape, the recording head including a write element and a read element in a known spatial relationship, wherein the read element is configured to access at least a portion of a reference track when the write element is accessing the active track. A controller determines a relative position of the transducer element to the reference track and repositions the recording head to write data to the active track. The read element may be a backward channel reader or dedicated read element of the recording head for reading reference tracks during read and/or write operations.
摘要翻译： 根据一个方面，提供了使用磁存储介质上的现有数据结构来确定记录头的位置的方法和系统。 在一个示例中，记录头将数据写入磁存储磁带上的活动轨道，记录头包括已知空间关系的写入元件和读取元件，其中读取元件被配置为访问至少一部分 写入元素访问活动轨道时的参考轨迹。 控制器确定换能器元件与参考轨道的相对位置，并重新定位记录头以将数据写入到主动轨道。 读取元件可以是用于在读取和/或写入操作期间读取参考轨道的记录头的反向通道读取器或专用读取元件。
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