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公开(公告)号：US09549933B2
公开(公告)日：2017-01-24
申请号：US14181234
申请日：2014-02-14
发明人： Scott Clunas , John Mervyn David Storey , Janet Elizabeth Rickard , David Horsley , Charles Robert Harrington , Claude Michel Wischik
IPC分类号： A61K31/538 , A61K31/352 , A61K31/382 , A61K31/498 , C07D241/46 , C07D265/38 , C07D311/82 , C07D311/90 , C07D335/12 , C07D491/22 , C07D493/16 , A61K31/4545 , A61K31/4745 , A61K31/5377 , A61K45/06 , C07D491/16 , G01N33/68
CPC分类号： C07D311/82 , A61K9/0053 , A61K31/352 , A61K31/382 , A61K31/4025 , A61K31/4545 , A61K31/4745 , A61K31/498 , A61K31/5377 , A61K31/538 , A61K45/06 , A61K49/00 , C07D241/46 , C07D265/38 , C07D311/84 , C07D311/90 , C07D335/12 , C07D335/14 , C07D335/20 , C07D491/16 , C07D491/22 , C07D493/16 , C09B11/24 , C09B11/28 , C09B17/00 , C09B19/00 , C09B21/00 , C09B57/00 , G01N33/6896 , G01N2800/7047
摘要： Described are a compound of formula (II) or (III): The compounds are effective in the treatment of disease, including a tauopathy condition or a disease of tau protein aggregation.
摘要翻译： 这些化合物在治疗疾病中是有效的，包括tau蛋白病变或tau蛋白聚集的疾病。
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公开(公告)号：US20140161731A1
公开(公告)日：2014-06-12
申请号：US14181234
申请日：2014-02-14
发明人： Scott Clunas , John Mervyn David Storey , Janet Elizabeth Rickard , David Horsley , Charles Robert Harrington , Claude Michel Wischik
IPC分类号： A61K31/538 , C07D491/16 , C07D311/82 , A61K31/352 , C07D335/12 , A61K31/382 , C07D241/46 , A61K31/498 , C07D265/38 , C07D311/90 , A61K31/5377 , A61K31/4545 , A61K45/06 , G01N33/68 , A61K31/4745
CPC分类号： C07D311/82 , A61K9/0053 , A61K31/352 , A61K31/382 , A61K31/4025 , A61K31/4545 , A61K31/4745 , A61K31/498 , A61K31/5377 , A61K31/538 , A61K45/06 , A61K49/00 , C07D241/46 , C07D265/38 , C07D311/84 , C07D311/90 , C07D335/12 , C07D335/14 , C07D335/20 , C07D491/16 , C07D491/22 , C07D493/16 , C09B11/24 , C09B11/28 , C09B17/00 , C09B19/00 , C09B21/00 , C09B57/00 , G01N33/6896 , G01N2800/7047
摘要： Described are a compound of formula (II) or (III): The compounds are effective in the treatment of disease, including a tauopathy condition or a disease of tau protein aggregation.
摘要翻译： 描述了式（II）或（III）的化合物：该化合物在治疗疾病中是有效的，包括tau蛋白病变或tau蛋白聚集的疾病。
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3.发明授权Compounds having photochemically removable protecting groups based on an electrocyclic reaction between a chromophore attached via an anilide group to a benzothiophene ring 失效基于通过苯胺基与苯并噻吩环连接的发色团之间的电环反应的具有光化学去除的保护基的化合物公开(公告)号：US08703970B2
公开(公告)日：2014-04-22
申请号：US13779141
申请日：2013-02-27
申请人： Marquette University
IPC分类号： C07D333/00 , C07D409/00 , C07D495/00 , C07D333/22 , A01N43/12 , A01N43/06 , A01N43/18 , A01N43/14 , A61K31/38
CPC分类号： C07D495/14 , C07D335/20 , C07D409/12 , Y02P20/55
摘要： Disclosed herein are compounds having photoremovable protecting groups which are removed after the compounds absorbs light of a given wavelength and undergo an electrocyclic reaction between a chromophore in the compound attached via an anilide to a benzothiophene ring.
摘要翻译： 本文公开了具有可光除保护基团的化合物，其在化合物吸收给定波长的光并在通过苯胺与苯并噻吩环连接的化合物中的发色团之间经历电环反应后除去。
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公开(公告)号：US20140066451A1
公开(公告)日：2014-03-06
申请号：US14071260
申请日：2013-11-04
申请人： BKG PHARMA APS
IPC分类号： C07D409/06 , A61K45/06 , C07D335/20 , A61K31/496 , A61K31/4436
CPC分类号： C07D409/06 , A61K31/4436 , A61K31/496 , A61K45/06 , C07D335/20
摘要： The claimed subject matter is directed to certain thioxanthene derivatives and phenothiazine derivatives suitable for use as anti-infective agents, in particular, for the treatment of infectious diseases. The claimed subject matter furthermore relates to compositions including said anti-infective agents.
摘要翻译： 所要求保护的主题涉及适合用作抗感染剂的某些噻吨衍生物和吩噻嗪衍生物，特别是用于治疗感染性疾病。 所要求保护的主题还涉及包含所述抗感染剂的组合物。
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公开(公告)号：US08604059B2
公开(公告)日：2013-12-10
申请号：US13265149
申请日：2010-04-20
IPC分类号： A61K31/445 , C07D409/06
CPC分类号： C07D409/06 , A61K31/4436 , A61K31/496 , A61K45/06 , C07D335/20
摘要： The claimed subject matter is directed to certain thioxanthene derivatives and phenothiazine derivatives suitable for use as anti-infective agents, in particular, for the treatment of infectious diseases. The claimed subject matter furthermore relates to compositions including said anti-infective agents.
摘要翻译： 所要求保护的主题涉及适合用作抗感染剂的某些噻吨衍生物和吩噻嗪衍生物，特别是用于治疗感染性疾病。 所要求保护的主题还涉及包含所述抗感染剂的组合物。
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公开(公告)号：US07820833B2
公开(公告)日：2010-10-26
申请号：US11512485
申请日：2006-08-30
申请人： Daniel S. Sem , Phani Kumar Pullela
发明人： Daniel S. Sem , Phani Kumar Pullela
IPC分类号： C07D311/90 , C07D311/14 , C07D335/20 , C07D311/82
CPC分类号： C07D311/90 , C07D311/82 , C07D335/12 , C07D335/20 , C07D409/12 , Y10T436/182
摘要： Disclosed herein are dithio compounds that include at least one fluorophore. The compounds additionally may include a different fluorophore or a non-fluorophore. The dithio compounds may be used as reagents for detecting thiol-containing compounds.
摘要翻译： 本文公开了包含至少一个荧光团的二硫代化合物。 化合物另外可以包括不同的荧光团或非荧光团。 二硫化合物可用作检测含硫醇化合物的试剂。
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7.发明授权
公开(公告)号：US3951961A
公开(公告)日：1976-04-20
申请号：US525967
申请日：1974-11-21
IPC分类号： A61K31/395 , C07D311/90 , C07D335/20 , C07D409/06 , C07D405/06
CPC分类号： C07D335/20 , A61K31/395
摘要： The present invention relates to novel xanthene and thioxanthene derivatives of the following general formula: ##SPC1##Wherein Y represents sulfur or oxygen, R.sup.1 represents hydrogen, chlorine, trifluoromethyl or dimethylsulfamoyl, R.sup.2 represents hydrogen or fluorine; and R.sup.3 and R.sup.4 each represents hydrogen or methyl, provided that R.sup.3 and R.sup.4 may not both represent hydrogen, or R.sup.3 and R.sup.4 taken together with the nitrogen atom form a piperazine or piperidine ring optionally substituted in the 4-position by a methyl group or a 2-hydroxyethyl group, if desired, esterified with an aliphatic carboxylic acid having from 1 to 17 carbon atoms inclusive, as well as non-toxic acid addition salts thereof.
摘要翻译： 本发明涉及以下通式的新型呫吨和噻吨衍生物：
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8.发明授权9-(3-amino-1-propynyl) derivatives of 9-xanthenols and 9-thioxanthenols and a process for their preparation 失效9-呫吨醇和9-噻吨醇的9-（3-氨基-1-丙炔基）衍生物及其制备方法
公开(公告)号：US3073847A
公开(公告)日：1963-01-15
申请号：US684160
申请日：1960-02-05
申请人： HOFFMANN LA ROCHE
IPC分类号： C07D213/74 , C07D311/90 , C07D335/20
CPC分类号： C07D213/74 , C07D311/90 , C07D335/20
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9.发明授权1-substituted-4-[3-(9-xanthylidene)-propyl] piperazines and 1-substituted-4-[3-(10-thiaxanthylidene) propyl]-piperazines 失效1-取代-4- [3-（9-亚苄基） - 丙基]哌嗪和1-取代-4- [3-（10-三亚甲基）丙基] - 哌嗪
公开(公告)号：US2940969A
公开(公告)日：1960-06-14
申请号：US67257857
申请日：1957-07-18
申请人： AMERICAN CYANAMID CO
IPC分类号： C07D311/90 , C07D335/20
CPC分类号： C07D311/90 , C07D335/20
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公开(公告)号：US20170088534A1
公开(公告)日：2017-03-30
申请号：US15373224
申请日：2016-12-08
发明人： Scott CLUNAS , John Mervyn Davd STOREY , Janet Elizabeth RICKARD , David HORSLEY , Charles Robert HARRINGTON , Claude Michel WISCHIK
IPC分类号： C07D311/82 , A61K31/5377 , A61K31/4025 , G01N33/68 , A61K9/00 , A61K45/06 , A61K31/4745 , A61K49/00 , A61K31/352 , A61K31/4545
CPC分类号： C07D311/82 , A61K9/0053 , A61K31/352 , A61K31/382 , A61K31/4025 , A61K31/4545 , A61K31/4745 , A61K31/498 , A61K31/5377 , A61K31/538 , A61K45/06 , A61K49/00 , C07D241/46 , C07D265/38 , C07D311/84 , C07D311/90 , C07D335/12 , C07D335/14 , C07D335/20 , C07D491/16 , C07D491/22 , C07D493/16 , C09B11/24 , C09B11/28 , C09B17/00 , C09B19/00 , C09B21/00 , C09B57/00 , G01N33/6896 , G01N2800/7047
摘要： Described are a compound of formula (II) or (III): The compounds are effective in the treatment of disease, including a tauopathy condition or a disease of tau protein aggregation.
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