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公开(公告)号：US11262287B2
公开(公告)日：2022-03-01
申请号：US17142529
申请日：2021-01-06
Inventor： YongKeun Park , JongHee Yoon , KyeoReh Lee , Young Dug Kim
IPC: G01N15/06 , C12Q1/18 , G01N33/483 , G01N15/00
Abstract: Provided is a sample property detecting apparatus including: a wave source configured to irradiate a wave towards a sample; a detector configured to detect a laser speckle that is generated when the wave is multiple-scattered by the sample, at every time point that is set in advance; and a controller configured to obtain a temporal correlation that is a variation in the detected laser speckle according to time, and to detect properties of the sample in real-time based on the temporal correlation, wherein the detector detects the laser speckle between the sample and the detector or from a region in the detector.
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公开(公告)号：US20210134054A1
公开(公告)日：2021-05-06
申请号：US16823453
申请日：2020-03-19
Inventor： YongKeun Park , Weisun Park , Youngju Jo , Hyunseok Min , Hyungjoo Cho
Abstract: Disclosed are a method and apparatus for generating a three-dimensional (3-D) molecular image based on a label-free method using a 3-D refractive index image and deep learning. The apparatus for generating a 3-D molecular image based on a label-free method using a 3-D refractive index image and deep learning may include a 3-D refractive index cell image measurement unit configured to measure a 3-D refractive index image of a cell to be monitored and a 3-D refractive index and fluorescence molecule staining image conversion unit configured to input a measured value of the 3-D refractive index image to a deep learning algorithm and to output a 3-D fluorescence molecule staining cell image of the cell.
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公开(公告)号：US09541375B2
公开(公告)日：2017-01-10
申请号：US13946240
申请日：2013-07-19
Inventor： Jae-guyn Lim , YongKeun Park , Jae-duck Jang , Hyeon-seung Yu , Seong-deok Lee , Woo-young Jang
CPC classification number: G01B9/02091 , G01B9/0201 , G01B9/02083 , G01N2021/1787
Abstract: A method and apparatus are provided to generate tomography images that performs the method. The apparatus and method are configured to determine a basis pattern from modulated phases of incident rays from a spatial light modulator according to a pattern of arranged pixels. The apparatus and method are further configured to perform spatial shift modulation shifting an arrangement of the pixels vertically or horizontally with respect to the basis pattern to obtain shift patterns of the basis pattern. The apparatus and method are configured to generate tomography images for the basis pattern and the shift patterns using spectrum signals of rays obtained from the incident rays passing through the spatial light modulator and entering a subject. The apparatus and method are configured to select a pattern that generates a clearest tomography image of the subject based on the generated tomography images.
Abstract translation: 提供了一种用于产生执行该方法的断层摄影图像的方法和装置。 该装置和方法被配置为根据排列的像素的图案从空间光调制器的入射光线的调制相位确定基本图案。 该装置和方法还被配置为执行空间移位调制，以相对于基本图案垂直或水平地移位像素的布置，以获得基本图案的移位模式。 该装置和方法被配置为使用从通过空间光调制器的入射光线获得的光线的频谱信号来生成用于基础图案和移位图案的断层图像，并且进入对象。 该装置和方法被配置为基于所生成的断层摄影图像来选择产生对象的最清晰的断层摄影图像的图案。
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公开(公告)号：US20230059661A1
公开(公告)日：2023-02-23
申请号：US17675370
申请日：2022-02-18
Inventor： YongKeun Park , Moosung Lee , Herve Jerome Hugonnet
Abstract: Various example embodiments provide a computing device of an algorithm for reconstructing a three-dimensional (3D) image in consideration of multiple scattering and a method of the same. According to various example embodiments, the computing device may be configured to set a 3D refractive index based on a plurality of 2D images for a specimen and to reconstruct a 3D image for the specimen from the set refractive index using a modified Born expansion considering multiple scattering to converge a calculation result.
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公开(公告)号：US11450062B2
公开(公告)日：2022-09-20
申请号：US16823453
申请日：2020-03-19
Inventor： YongKeun Park , Weisun Park , Youngju Jo , Hyunseok Min , Hyungjoo Cho
Abstract: Disclosed are a method and apparatus for generating a three-dimensional (3-D) molecular image based on a label-free method using a 3-D refractive index image and deep learning. The apparatus for generating a 3-D molecular image based on a label-free method using a 3-D refractive index image and deep learning may include a 3-D refractive index cell image measurement unit configured to measure a 3-D refractive index image of a cell to be monitored and a 3-D refractive index and fluorescence molecule staining image conversion unit configured to input a measured value of the 3-D refractive index image to a deep learning algorithm and to output a 3-D fluorescence molecule staining cell image of the cell.
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Patent Agency Ranking
公开(公告)号：US10914665B2
公开(公告)日：2021-02-09
申请号：US16697373
申请日：2019-11-27
Inventor： YongKeun Park , JongHee Yoon , Kyeoreh Lee , Young Dug Kim , Nam Kyun Kim
IPC: G01N15/06 , C12Q1/18 , G01N33/483 , G01N15/00
Abstract: Provided is a sample property detecting apparatus including: a wave source configured to irradiate a wave towards a sample; a detector configured to detect a laser speckle that is generated when the wave is multiple-scattered by the sample, at every time point that is set in advance; and a controller configured to obtain a temporal correlation that is a variation in the detected laser speckle according to time, and to detect properties of the sample in real-time based on the temporal correlation, wherein the detector detects the laser speckle between the sample and the detector or from a region in the detector.
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公开(公告)号：US10585039B1
公开(公告)日：2020-03-10
申请号：US16184677
申请日：2018-11-08
Inventor： Hui Jun Park , Kyeo Reh Lee , Seung Woo Shin , YongKeun Park
Abstract: An optical detection system includes a sample portion accommodating a sample, a wave source emitting waves to the sample portion, an optical portion provided on a path of an output wave output from the sample portion, and comprising a first spatial light modulator that modulates part of the output wave to a first wave and a second spatial light modulator that modulates part of the output wave to a second wave, a lens portion focusing the first wave and the second wave output from the optical portion, and a detection portion detecting a focused wave that is focused by the lens portion, in which the first spatial light modulator and the second spatial light modulator modulate the output wave such that the first wave and the second wave have destructive interference with respect to the sample under an already known condition.
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公开(公告)号：US10001467B2
公开(公告)日：2018-06-19
申请号：US15170508
申请日：2016-06-01
Inventor： YongKeun Park , Jonghee Yoon , KyeoReh Lee
IPC: G01N21/47 , G01N33/483 , G01N33/02 , G01N21/49
CPC classification number: G01N33/483 , G01N15/06 , G01N21/4795 , G01N21/49 , G01N33/02 , G01N2015/0065 , G01N2015/0687 , G01N2015/0693 , G01N2021/479 , G01N2201/06113 , G01N2201/066
Abstract: An apparatus and method for detecting microbes use laser speckles. The apparatus includes a light source configured to irradiate light into a sample to detect microbes, and a measuring part configured to measure laser speckles, which are formed due to a multiple scattering of the light which is incident into the sample, every reference time and to measure concentration of the microbes contained in the sample based on temporal correlation of the measured laser speckles.
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公开(公告)号：US12228509B2
公开(公告)日：2025-02-18
申请号：US17273631
申请日：2019-09-06
Inventor： YongKeun Park , KyeoReh Lee , Seungwoo Shin , Geon Kim , Young Dug Kim
Abstract: According to an embodiment of the present disclosure, provided is an apparatus for providing microorganism information, including: a receiving unit configured to receive a plurality of images obtained by photographing in time series an outgoing wave emitted from a sample; a detecting unit configured to extract a feature of a change over time from the plurality of images obtained by photographing in time series; a learning unit configured to machine-learn classification criteria based on the extracted feature; and a determining unit configured to classify the type or concentration of a microorganism included in the sample based on the classification criteria, wherein each of the plurality of images includes speckle information generated by multiple scattering by the microorganism due to waves incident on the sample.
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公开(公告)号：US10884378B2
公开(公告)日：2021-01-05
申请号：US15928153
申请日：2018-03-22
Inventor： YongKeun Park , Jong chan Park , KyeoReh Lee
Abstract: Disclosed herein are an apparatus and method for forming a 3D holographic image using non-periodically structured optical elements. The 3D holographic image apparatus includes a light source configured to radiate light, a spatial light modulator configured to modulate the light projected by the light source, and a non-periodic optical element configured to modulate incident light by refracting, diffracting or reflecting the direction of the incident light in a plurality of directions when the light modulated by the spatial light modulator is incident. A 3D holographic image may be formed based on the light modulated by the non-periodic optical element.
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