公开(公告)号：US20180119169A1

公开(公告)日：2018-05-03

申请号：US15709822

申请日：2017-09-20

Applicant: Korea Institute of Science and Technology

Inventor： Do Hee KIM ,  Seul Gi Shin ,  Sung Su Lim ,  Ae Nim Pae ,  Dong Jin Kim ,  Yun Kyung Kim

IPC: C12N15/85 ,  A01K67/027 ,  G01N33/50 ,  C07K14/47 ,  G01N33/68

CPC classification number: C12N15/8509 ,  A01K67/0275 ,  A01K2207/15 ,  A01K2217/05 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0312 ,  A01K2267/0318 ,  C07K14/47 ,  C07K2319/60 ,  C12N2015/8527 ,  C12N2015/8536 ,  C12N2015/859 ,  C12N2830/008 ,  G01N33/5058 ,  G01N33/5088 ,  G01N33/6896 ,  G01N2800/2814

Abstract: Disclosed is a vector pair for screening tau oligomer formation, a mouse embryo introduced with the vector pair, a transgenic model mouse of neurological disease, obtained from the mouse embryo, and a method of screening a tau oligomer formation inhibitor candidate using the transgenic model mouse. More specifically, the present invention provides vector pair for screening tau oligomer formation, comprising: a first vector comprising a first tau gene, a first fluorescence protein gene and a first neuron-specific promoter; and a second vector comprising a second tau gene, a second fluorescence protein gene and a second neuron-specific promoter, wherein a protein expressed from the first fluorescence protein gene and a protein expressed from the second fluorescence protein gene bind to each other to display fluorescence, by association between a protein expressed from the first tau gene and a protein expressed from the second tau gene.