公开(公告)号：US20220170051A1

公开(公告)日：2022-06-02

申请号：US17599153

申请日：2020-03-20

Applicant: Korea University Research and Business Foundation

Inventor： Jeewon LEE ,  Hyun Jin KIM

IPC: C12P7/04 ,  C12N9/02 ,  C12N11/04 ,  C12N9/96

Abstract: The present invention relates to novel enzyme nanoparticles capable of converting methane into methanol, in which key active sites of methane-oxidizing bacteria are fused with each other and expressed on a protein that can be self-assembled in cells to form nanoparticles, and specifically to enzyme nanoparticles including a protein having methane monooxygenase (MMO) activity and active sites of the methane oxidase, a method for production thereof, a recombinant microorganism into which a nucleic acid encoding the protein and the active site of the methane oxidase is introduced, and immobilized enzyme nanoparticles including the enzyme nanoparticles loaded on a carrier.

公开(公告)号：US20200181204A1

公开(公告)日：2020-06-11

申请号：US16663651

申请日：2019-10-25

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Jeewon LEE ,  Bo Ram LEE

IPC: C07K14/005 ,  C07K16/18 ,  C12N7/00 ,  A61K49/00 ,  A61K9/51

Abstract: The present invention relates to recombinant self-assembling protein nanoparticles presenting an albumin-binding peptide at the surface. For the recombinant self-assembling protein nanoparticles according to the present invention, an albumin-binding peptide can reduce the immunogenicity of the recombinant self-assembling protein nanoparticles because the albumin-binding peptide is presented at the surface, and thus binds to an albumin protein present in vivo, and the albumin-binding peptide can also provide the cancer delivery function of the recombinant self-assembling protein nanoparticles because the albumin-binding peptide binds to albumin around cancer. Simultaneously, the binding of the albumin-binding peptide to albumin can significantly increase the in vivo residence time of the recombinant self-assembling protein nanoparticles, thus increasing the potential for use in various medical applications.

公开(公告)号：US20160349250A1

公开(公告)日：2016-12-01

申请号：US15152259

申请日：2016-05-11

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Jeewon LEE ,  Eun Jung LEE ,  Jong Hwan LEE

IPC: G01N33/543 ,  G01N33/58

CPC classification number: G01N33/54346 ,  G01N33/56988 ,  G01N33/582 ,  G01N2333/155

Abstract: The present invention relates to a use of a protein nanoparticle-based hydrogel, and more particularly, to a use of a protein nanoparticle-based hydrogel capable of highly sensitive and simultaneous multi-detection of disease markers by using a hydrogel within which protein nanoparticles presenting multiple copies of disease marker detection probes are immobilized.

Abstract translation: 本发明涉及蛋白质纳米颗粒型水凝胶的使用，更具体地，涉及使用蛋白质纳米颗粒型水凝胶，其能够通过使用其中蛋白质纳米粒子呈现的水凝胶来高度灵敏和同时多重检测疾病标记物 疾病标记物检测探针的多个拷贝被固定化。