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    Reagents and method for modulating Dkk-mediated interactions
    1.
    发明授权
    Reagents and method for modulating Dkk-mediated interactions 失效
    用于调节Dkk介导的相互作用的试剂和方法

    公开(公告)号：US07700101B2

    公开(公告)日：2010-04-20

    申请号：US11655924

    申请日：2007-01-22

    申请人： Kristina M. Allen ,  Anthony Anisowicz ,  Veronique Damagnez ,  John A. Robinson ,  Paul J. Yaworsky ,  Bheem M. Bhat

    发明人： Kristina M. Allen ,  Anthony Anisowicz ,  Veronique Damagnez ,  John A. Robinson ,  Paul J. Yaworsky ,  Bheem M. Bhat

    IPC分类号： A61K39/395

    CPC分类号： C07K16/28 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/34 ,  G01N33/5041 ,  G01N33/6887 ,  G01N2333/4715 ,  G01N2500/02

    摘要： The present invention provides reagents, compounds, compositions, and methods relating to novel interactions of the extracellular domain of LRP5, HBM (a variant of LRP5), and/or LRP6 with Dkk, including Dkk-1. The various nucleic acids, polypeptides, antibodies, assay methods, diagnostic methods, and methods of treatment of the present invention are related to and impact on Dkk, LRP5, LRP6, HBM, and Wnt signaling. Dkk, LRP5, LRP6, HBM, and Wnt are implicated in bone and lipid cellular signaling. Thus, the present invention provides reagents and methods for modulating lipid levels and/or bone mass and is useful in the treatment and diagnosis of abnormal lipid levels and bone mass disorders, such as osteoporosis.

    摘要翻译： 本发明提供了与LRP5，HBM（LRP5的变体）和/或LRP6与Dkk（包括Dkk-1）的细胞外结构域的新的相互作用有关的试剂，化合物，组合物和方法。 本发明的各种核酸，多肽，抗体，测定方法，诊断方法和治疗方法与Dkk，LRP5，LRP6，HBM和Wnt信号传导有关并对其影响。 Dkk，LRP5，LRP6，HBM和Wnt涉及骨和脂质细胞信号传导。 因此，本发明提供用于调节脂质水平和/或骨量的试剂和方法，并且可用于治疗和诊断异常脂质水平和骨质量障碍，例如骨质疏松症。

    Tissue-specific regulatory elements
    4.
    发明授权
    Tissue-specific regulatory elements 失效
    组织特异性调节元件

    公开(公告)号：US06303370B1

    公开(公告)日：2001-10-16

    申请号：US09047031

    申请日：1998-03-24

    申请人： Claudia Kappen ,  Paul J. Yaworsky

    发明人： Claudia Kappen ,  Paul J. Yaworsky

    IPC分类号： C12N1500

    CPC分类号： C12N15/85 ,  C12N2830/002 ,  C12N2830/008 ,  C12N2830/60

    摘要： The invention provides methods and materials related to the regulation of nucleic acid expression. Specifically, the invention provides midbrain-specific and NS-specific regulatory elements as well as regulatory elements that potentiate nucleic acid expression and regulatory elements that cooperate with other regulatory elements. In addition, the invention provides temporal regulatory elements that regulate nucleic acid expression in a temporal manner. Further, the invention provides nucleic acid constructs that contain these regulatory elements in combination with selected nucleic acid sequences. The invention also provides cells and animals that contain these regulatory elements and constructs as well as methods of providing an animal with a selected nucleic acid sequence that is expressed in a tissue-specific or temporal manner.

    摘要翻译： 本发明提供了与调控核酸表达有关的方法和材料。 具体地，本发明提供了中脑特异性和NS特异性调节元件以及增强核酸表达和与其它调节元件配合的调控元件的调节元件。 此外，本发明提供了以时间方式调节核酸表达的时间调控元件。 此外，本发明提供了与选择的核酸序列组合含有这些调节元件的核酸构建体。 本发明还提供了含有这些调节元件和构建体的细胞和动物，以及向动物提供以组织特异性或时间方式表达的选择的核酸序列的方法。