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公开(公告)号：US07416849B2
公开(公告)日：2008-08-26
申请号：US10477173
申请日：2002-05-13
申请人： Kristina Allen , Anthony Anisowicz , James R. Graham , Arturo Morales , Paul J. Yaworsky , Wei Liu
发明人： Kristina Allen , Anthony Anisowicz , James R. Graham , Arturo Morales , Paul J. Yaworsky , Wei Liu
IPC分类号： G01N33/50 , C12N1/19 , C12N1/21 , C12N15/11 , C12N15/12 , C12N15/63 , C12N5/10 , C07K14/00 , C07K14/435
CPC分类号： C12N15/8509 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/50 , A01K2267/02 , A01K2267/03 , A01K2267/0362 , A61K38/00 , C07K14/51 , C07K16/18 , C12N2800/30 , C12N2800/60 , C12N2830/00 , C12N2830/008 , C12N2830/30 , C12N2840/105 , C12N2840/203 , G01N2333/51 , G01N2500/00
摘要： The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
摘要翻译： 本发明涉及用于表达在动物细胞和转基因动物中衍生自HBM，LRP5或LRP6的HBM样多肽的方法和材料。 本发明还涉及表达HBM样多肽的转基因动物。 本发明提供核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定涉及骨发育的分子的方法，以及诊断和治疗涉及的疾病的方法 骨发育和脂质调节。 在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。
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公开(公告)号：US20090136507A1
公开(公告)日：2009-05-28
申请号：US12219294
申请日：2008-07-18
申请人： Kristina Allen , Anthony Anisowicz , James R. Graham , Arturo Morales , Paul J. Yaworsky , Wei Liu
发明人： Kristina Allen , Anthony Anisowicz , James R. Graham , Arturo Morales , Paul J. Yaworsky , Wei Liu
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C12N15/8509 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/50 , A01K2267/02 , A01K2267/03 , A01K2267/0362 , A61K38/00 , C07K14/51 , C07K16/18 , C12N2800/30 , C12N2800/60 , C12N2830/00 , C12N2830/008 , C12N2830/30 , C12N2840/105 , C12N2840/203 , G01N2333/51 , G01N2500/00
摘要： The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
摘要翻译： 本发明涉及用于表达在动物细胞和转基因动物中衍生自HBM，LRP5或LRP6的HBM样多肽的方法和材料。 本发明还涉及表达HBM样多肽的转基因动物。 本发明提供核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定涉及骨发育的分子的方法，以及诊断和治疗涉及的疾病的方法 骨发育和脂质调节。 在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。
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公开(公告)号：US20050070699A1
公开(公告)日：2005-03-31
申请号：US10477173
申请日：2002-05-13
申请人： Kristina Allen , Anthony Anisowicz , James Graham , Arturo Morales , Paul Yaworsky , Wei Liu
发明人： Kristina Allen , Anthony Anisowicz , James Graham , Arturo Morales , Paul Yaworsky , Wei Liu
IPC分类号： A01K67/027 , A61K35/00 , A61K38/00 , A61K39/395 , A61K45/00 , A61P3/00 , A61P19/00 , A61P19/10 , C07K14/47 , C07K14/51 , C07K16/18 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/85 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , C07H21/04 , C12N9/64
CPC分类号： C12N15/8509 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/50 , A01K2267/02 , A01K2267/03 , A01K2267/0362 , A61K38/00 , C07K14/51 , C07K16/18 , C12N2800/30 , C12N2800/60 , C12N2830/00 , C12N2830/008 , C12N2830/30 , C12N2840/105 , C12N2840/203 , G01N2333/51 , G01N2500/00
摘要： The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
摘要翻译： 本发明涉及用于表达在动物细胞和转基因动物中衍生自HBM，LRP5或LRP6的HBM样多肽的方法和材料。 本发明还涉及表达HBM样多肽的转基因动物。 本发明提供核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定涉及骨发育的分子的方法，以及诊断和治疗涉及的疾病的方法 骨发育和脂质调节。 在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。
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公开(公告)号：US07700101B2
公开(公告)日：2010-04-20
申请号：US11655924
申请日：2007-01-22
申请人： Kristina M. Allen , Anthony Anisowicz , Veronique Damagnez , John A. Robinson , Paul J. Yaworsky , Bheem M. Bhat
发明人： Kristina M. Allen , Anthony Anisowicz , Veronique Damagnez , John A. Robinson , Paul J. Yaworsky , Bheem M. Bhat
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , C07K16/18 , C07K16/2863 , C07K16/30 , C07K2317/34 , G01N33/5041 , G01N33/6887 , G01N2333/4715 , G01N2500/02
摘要： The present invention provides reagents, compounds, compositions, and methods relating to novel interactions of the extracellular domain of LRP5, HBM (a variant of LRP5), and/or LRP6 with Dkk, including Dkk-1. The various nucleic acids, polypeptides, antibodies, assay methods, diagnostic methods, and methods of treatment of the present invention are related to and impact on Dkk, LRP5, LRP6, HBM, and Wnt signaling. Dkk, LRP5, LRP6, HBM, and Wnt are implicated in bone and lipid cellular signaling. Thus, the present invention provides reagents and methods for modulating lipid levels and/or bone mass and is useful in the treatment and diagnosis of abnormal lipid levels and bone mass disorders, such as osteoporosis.
摘要翻译： 本发明提供了与LRP5，HBM（LRP5的变体）和/或LRP6与Dkk（包括Dkk-1）的细胞外结构域的新的相互作用有关的试剂，化合物，组合物和方法。 本发明的各种核酸，多肽，抗体，测定方法，诊断方法和治疗方法与Dkk，LRP5，LRP6，HBM和Wnt信号传导有关并对其影响。 Dkk，LRP5，LRP6，HBM和Wnt涉及骨和脂质细胞信号传导。 因此，本发明提供用于调节脂质水平和/或骨量的试剂和方法，并且可用于治疗和诊断异常脂质水平和骨质量障碍，例如骨质疏松症。
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5.发明授权Method of synthesizing and purifying Dkk proteins and Dkk proteins obtained thereby 失效合成和纯化由此得到的Dkk蛋白质和Dkk蛋白质的方法公开(公告)号：US07867699B2
公开(公告)日：2011-01-11
申请号：US10593089
申请日：2005-03-23
CPC分类号： C07K14/4703
摘要： The invention relates to a novel method of inexpensively synthesizing large quantities of an essentially pure, biologically active, glycosylated Dkk protein, including mammalian and human Dkk proteins (e.g., human Dkk1). The invention further relates to the synthetically produced essentially purified, glycosylated and biologically active Dkk protein, and the characteristics of the protein.
摘要翻译： 本发明涉及一种低成本合成大量基本上纯的，生物活性的糖基化Dkk蛋白质，包括哺乳动物和人类Dkk蛋白（例如人类Dkk1）的新方法。 本发明还涉及合成产生的基本纯化的糖基化和生物活性的Dkk蛋白质和蛋白质的特征。
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公开(公告)号：US20070128187A1
公开(公告)日：2007-06-07
申请号：US11655924
申请日：2007-01-22
申请人： Kristina Allen , Anthony Anisowicz , Veronique Damagnez , John Robinson , Paul Yaworsky , Bheem Bhat
发明人： Kristina Allen , Anthony Anisowicz , Veronique Damagnez , John Robinson , Paul Yaworsky , Bheem Bhat
IPC分类号： C12Q1/68 , G01N33/53 , A61K39/395 , A61K38/17 , C07K14/705 , C07K16/28 , C07H21/04 , C12P21/06
CPC分类号： C07K16/28 , C07K16/18 , C07K16/2863 , C07K16/30 , C07K2317/34 , G01N33/5041 , G01N33/6887 , G01N2333/4715 , G01N2500/02
摘要： The present invention provides reagents, compounds, compositions, and methods relating to novel interactions of the extracellular domain of LRP5, HBM (a variant of LRP5), and/or LRP6 with Dkk, including Dkk-1. The various nucleic acids, polypeptides, antibodies, assay methods, diagnostic methods, and methods of treatment of the present invention are related to and impact on Dkk, LRP5, LRP6, HBM, and Wnt signaling. Dkk, LRP5, LRP6, HBM, and Wnt are implicated in bone and lipid cellular signaling. Thus, the present invention provides reagents and methods for modulating lipid levels and/or bone mass and is useful in the treatment and diagnosis of abnormal lipid levels and bone mass disorders, such as osteoporosis.
摘要翻译： 本发明提供了与LRP5，HBM（LRP5的变体）和/或LRP6与Dkk（包括Dkk-1）的细胞外结构域的新的相互作用有关的试剂，化合物，组合物和方法。 本发明的各种核酸，多肽，抗体，测定方法，诊断方法和治疗方法与Dkk，LRP5，LRP6，HBM和Wnt信号传导有关并对其影响。 Dkk，LRP5，LRP6，HBM和Wnt涉及骨和脂质细胞信号传导。 因此，本发明提供用于调节脂质水平和/或骨量的试剂和方法，并且可用于治疗和诊断异常脂质水平和骨质量障碍，例如骨质疏松症。
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7.发明申请Method of Synthesizing and Purifying Dkk Proteins and Dkk Proteins Obtained Thereby 失效合成和纯化由此得到的Dkk蛋白质和Dkk蛋白质的方法公开(公告)号：US20080038775A1
公开(公告)日：2008-02-14
申请号：US10593089
申请日：2005-03-23
CPC分类号： C07K14/4703
摘要： The invention relates to a novel method of inexpensively synthesizing large quantities of an essentially pure, biologically active, glycosylated Dkk protein, including mammalian and human Dkk proteins (e.g., human Dkk1). The invention further relates to the synthetically produced essentially purified, glycosylated and biologically active Dkk protein, and the characteristics of the protein.
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公开(公告)号：US5470970A
公开(公告)日：1995-11-28
申请号：US121714
申请日：1993-09-01
申请人： Ruth Sager , Anthony Anisowicz , Zhiqiang Zou
发明人： Ruth Sager , Anthony Anisowicz , Zhiqiang Zou
IPC分类号： A61K38/00 , C07K14/47 , C07K14/81 , C07K16/38 , C12N15/15 , C12Q1/68 , G01N33/50 , G01N33/574 , C12N1/21 , C12N5/10
CPC分类号： C07K16/38 , C07K14/47 , C07K14/811 , C12Q1/6841 , C12Q1/6886 , G01N33/5011 , G01N33/57484 , A61K38/00 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , Y10S530/828
摘要： An isolated DNA encoding a polypeptide substantially identical to maspin (SEQ ID NO:1); a substantially purified preparation of maspin; an antibody specific for maspin; and use of such DNAs and antibodies in diagnostic, screening, and therapeutic methods.
摘要翻译： 编码与maspin基本相同的多肽的分离的DNA（SEQ ID NO：1）; 一种基本上纯化的maspin制剂; 对maspin具有特异性的抗体; 以及在诊断，筛选和治疗方法中使用这样的DNA和抗体。
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公开(公告)号：US20070292866A1
公开(公告)日：2007-12-20
申请号：US11634755
申请日：2006-12-06
申请人： Huajan Wang , Anthony Anisowicz , Richard Del Mastro , Hui Huang , Sergey Mamaev
发明人： Huajan Wang , Anthony Anisowicz , Richard Del Mastro , Hui Huang , Sergey Mamaev
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6844 , C12Q2521/331
摘要： This invention relates to methodologies that detect global changes in the methylation of human genomic DNA as well as changes in methylation in specific regions of the human genome. The methodologies have utility in the diagnosis, prognosis and monitoring of therapeutic treatment for any human disease. Further, the invention relates to methodologies that can detect global changes in the methylation of human genomic DNA that is a consequence of diet and/or dietary supplements. The invention also relates to identifying novel DNA methylation biomarkers that are associated with human disease.
摘要翻译： 本发明涉及检测人类基因组DNA甲基化的全球变化以及人类基因组特定区域甲基化变化的方法。 该方法可用于任何人类疾病的治疗性治疗的诊断，预后和监测。 此外，本发明涉及可以检测作为饮食和/或膳食补充剂的结果的人类基因组DNA甲基化的全球变化的方法。 本发明还涉及鉴定与人类疾病相关的新的DNA甲基化生物标志物。
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公开(公告)号：US5801001A
公开(公告)日：1998-09-01
申请号：US477108
申请日：1995-06-07
申请人： Ruth Sager , Zhiqiang Zou , Anthony Anisowicz
发明人： Ruth Sager , Zhiqiang Zou , Anthony Anisowicz
IPC分类号： A61K38/00 , C07K14/47 , C07K14/81 , C07K16/38 , C12N15/15 , C12Q1/68 , G01N33/50 , G01N33/574 , G01N33/536 , C07K16/30
CPC分类号： C07K16/38 , C07K14/47 , C07K14/811 , C12Q1/6841 , C12Q1/6886 , G01N33/5011 , G01N33/57484 , A61K38/00 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , Y10S530/828
摘要： An isolated DNA encoding a polypeptide substantially identical to maspin (SEQ ID NO:1); a substantially purified preparation of maspin; an antibody specific for maspin; and use of such DNAs and antibodies in diagnostic, screening, and therapeutic methods.
摘要翻译： 编码与maspin基本相同的多肽的分离的DNA（SEQ ID NO：1）; 一种基本上纯化的maspin制剂; 对maspin具有特异性的抗体; 以及在诊断，筛选和治疗方法中使用这样的DNA和抗体。
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