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18 条记录 (耗时 0.054 秒)

    Reagents and method for modulating Dkk-mediated interactions
    1.
    发明授权
    Reagents and method for modulating Dkk-mediated interactions 失效
    用于调节Dkk介导的相互作用的试剂和方法

    公开(公告)号：US07700101B2

    公开(公告)日：2010-04-20

    申请号：US11655924

    申请日：2007-01-22

    申请人： Kristina M. Allen ,  Anthony Anisowicz ,  Veronique Damagnez ,  John A. Robinson ,  Paul J. Yaworsky ,  Bheem M. Bhat

    发明人： Kristina M. Allen ,  Anthony Anisowicz ,  Veronique Damagnez ,  John A. Robinson ,  Paul J. Yaworsky ,  Bheem M. Bhat

    IPC分类号： A61K39/395

    CPC分类号： C07K16/28 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/34 ,  G01N33/5041 ,  G01N33/6887 ,  G01N2333/4715 ,  G01N2500/02

    摘要： The present invention provides reagents, compounds, compositions, and methods relating to novel interactions of the extracellular domain of LRP5, HBM (a variant of LRP5), and/or LRP6 with Dkk, including Dkk-1. The various nucleic acids, polypeptides, antibodies, assay methods, diagnostic methods, and methods of treatment of the present invention are related to and impact on Dkk, LRP5, LRP6, HBM, and Wnt signaling. Dkk, LRP5, LRP6, HBM, and Wnt are implicated in bone and lipid cellular signaling. Thus, the present invention provides reagents and methods for modulating lipid levels and/or bone mass and is useful in the treatment and diagnosis of abnormal lipid levels and bone mass disorders, such as osteoporosis.

    摘要翻译： 本发明提供了与LRP5，HBM（LRP5的变体）和/或LRP6与Dkk（包括Dkk-1）的细胞外结构域的新的相互作用有关的试剂，化合物，组合物和方法。 本发明的各种核酸，多肽，抗体，测定方法，诊断方法和治疗方法与Dkk，LRP5，LRP6，HBM和Wnt信号传导有关并对其影响。 Dkk，LRP5，LRP6，HBM和Wnt涉及骨和脂质细胞信号传导。 因此，本发明提供用于调节脂质水平和/或骨量的试剂和方法，并且可用于治疗和诊断异常脂质水平和骨质量障碍，例如骨质疏松症。

    Assay and reagents for identifying anti-proliferative agents
    6.
    发明授权
    Assay and reagents for identifying anti-proliferative agents 失效
    用于鉴定抗增殖剂的测定和试剂

    公开(公告)号：US06251585B1

    公开(公告)日：2001-06-26

    申请号：US08428762

    申请日：1995-04-24

    申请人： Giulio Draetta ,  Guillaume Cottarel ,  Veronique Damagnez

    发明人： Giulio Draetta ,  Guillaume Cottarel ,  Veronique Damagnez

    IPC分类号： C12Q168

    CPC分类号： G01N33/5011 ,  C12N9/16

    摘要： The present invention makes available assays and reagents for identifying anti-proliferative agents, such as mitotic and meiotic inhibitors. The present assay provides a simple and rapid screening test which relies on scoring for positive cellular proliferation as indicative of anti-mitotic or anti-meiotic activity, and comprises contacting a candidate agent with a cell which has an impaired cell-cycle checkpoint and measuring the level of proliferation in the presence and absence of the agent. The checkpoint impairment is such that it either causes premature progression of the cell through at least a portion of a cell-cycle or inhibition of normal progression of the cell through at least a portion of a cell-cycle, but can be off-set by the action of an agent which inhibits at least one regulatory protein of the cell-cycle in a manner which counter-balances the effect of the impairment.

    摘要翻译： 本发明提供用于鉴定抗增殖剂（如有丝分裂和减数分裂抑制剂）的测定和试剂。 本测定提供了一种简单快速的筛选试验，其依赖于阳性细胞增殖的评分作为抗有丝分裂或抗减数分裂活性的指示，并且包括使候选试剂与具有受损的细胞周期检查点的细胞接触并测量 药剂存在和不存在时的增殖水平。 检查点受损使得其通过细胞周期的至少一部分或者通过细胞周期的至少一部分抑制细胞的正常进展来导致细胞过早进展，但是可以通过 抑制细胞周期的至少一种调节蛋白的药物的作用，其以抵消该损伤的作用的方式。