公开(公告)号：US20070049151A1

公开(公告)日：2007-03-01

申请号：US11209823

申请日：2005-08-24

申请人： Kuang Chao ,  Chien Ho

发明人： Kuang Chao ,  Chien Ho

IPC分类号： B32B5/26 ,  D03D15/00

CPC分类号： D03D15/00 ,  D02G3/185 ,  D02G3/36 ,  D03D15/0011 ,  D03D15/0027 ,  D10B2101/06 ,  D10B2101/12 ,  D10B2201/02 ,  D10B2331/04 ,  D10B2401/041 ,  D10B2401/063 ,  D10B2501/00 ,  D10B2505/02 ,  Y10T442/3073 ,  Y10T442/3146 ,  Y10T442/3472 ,  Y10T442/3504 ,  Y10T442/40

摘要： A composite fabric suitable for use as an electric or electronic apparatus shell after stamping through a heat press is disclosed to include a surface layer, which is a woven fabric made out of soft fibers, and a bottom layer, which is a woven fabric made out of a bi-component yarn, which has a yarn core obtained from high strength fiber and a yarn sheath prepared from low melting point polyester fiber and wound round the yarn core.

摘要翻译： 公开了一种适用于通过热压机冲压后用作电子或电子设备外壳的复合织物，包括由软纤维制成的机织织物的表面层和底层，其为制成的织物 具有由高强度纤维得到的纱芯和由低熔点聚酯纤维制成并在纱线芯上缠绕的纱线鞘的双组分纱线。

公开(公告)号：US06803212B2

公开(公告)日：2004-10-12

申请号：US09986633

申请日：2001-11-09

申请人： Chien Ho ,  Ching-Hsuan Tsai ,  Tsuei-Yun Fang ,  Tong-Jian Shen

发明人： Chien Ho ,  Ching-Hsuan Tsai ,  Tsuei-Yun Fang ,  Tong-Jian Shen

IPC分类号： C12P2106

CPC分类号： C07K14/805 ,  A61K38/00

摘要： Non-naturally occurring mutant hemoglobins rHb (&bgr;N108Q) and rHb (&bgr;L105W) are provided that have a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. rHb (&bgr;N108Q) also exhibits enhanced stability against autoxidation. The mutant hemoglobins are preferably produced by recombinant DNA techniques. Such mutant hemoglobins may be used as a component of a blood substitute and hemoglobin therapeutics.

摘要翻译： 提供非天然存在的突变体血红蛋白rHb（βN108Q）和rHb（βL105W），其具有比天然血红蛋白低的氧亲和力，但氧结合中的高协同性。 rHb（betaN108Q）也表现出增强的抗氧化稳定性。 突变体血红蛋白优选通过重组DNA技术产生。 这种突变体血红蛋白可以用作血液代用品和血红蛋白治疗剂的组分。

公开(公告)号：US5843888A

公开(公告)日：1998-12-01

申请号：US432071

申请日：1995-05-01

申请人： Chien Ho ,  Hyun-Won Kim ,  Tong-Jian Shen

发明人： Chien Ho ,  Hyun-Won Kim ,  Tong-Jian Shen

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/16 ,  A61P7/08 ,  C07K14/805 ,  C12N1/21 ,  C12P21/02 ,  C12R1/19 ,  C12P21/06

CPC分类号： C07K14/805 ,  A61K38/00

摘要： A non-naturally occurring mutant hemoglobin (.alpha.96Val.fwdarw.Trp) is provided that has a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. The mutant hemoglobin is preferably obtained by recombinant DNA techniques. Such a mutant hemoglobin may be used as a component of a blood substitute.

摘要翻译： 提供了非天然存在的突变体血红蛋白（alpha 96Val-> Trp），其具有比天然血红蛋白更低的氧亲和力，但是氧结合中的高协调性。 突变体血红蛋白优选通过重组DNA技术获得。 这种突变体血红蛋白可以用作血液代用品的组分。

公开(公告)号：US06812328B2

公开(公告)日：2004-11-02

申请号：US09986666

申请日：2001-11-09

申请人： Chien Ho ,  Ching-Hsuan Tsai ,  Tsuei-Yun Fang ,  Tong-Jian Shen

发明人： Chien Ho ,  Ching-Hsuan Tsai ,  Tsuei-Yun Fang ,  Tong-Jian Shen

IPC分类号： A61K3514

CPC分类号： C07K14/805 ,  A61K38/00

摘要： Non-naturally occurring mutant hemoglobins rHb (&bgr;N108Q) and rHb (&bgr;L105W) are provided that have a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. rHb (&bgr;N108Q) also exhibits enhanced stability against autoxidation. The mutant hemoglobins are preferably produced by recombinant DNA techniques. Such mutant hemoglobins may be used as a component of a blood substitute and hemoglobin therapeutics.

公开(公告)号：US06486123B1

公开(公告)日：2002-11-26

申请号：US09598218

申请日：2000-06-21

申请人： Chien Ho ,  Ching-Hsuan Tsai ,  Tsuei-Yun Fang ,  Tong-Jian Shen

发明人： Chien Ho ,  Ching-Hsuan Tsai ,  Tsuei-Yun Fang ,  Tong-Jian Shen

IPC分类号： C07K14885

CPC分类号： C07K14/805 ,  A61K38/00

摘要： Non-naturally occurring mutant hemoglobins rHb (&bgr;N108Q) and rHb (&bgr;L105W) are provided that have a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. rHb (&bgr;N108Q) also exhibits enhanced stability against autoxidation. The mutant hemoglobins are preferably produced by recombinant DNA techniques. Such mutant hemoglobins may be used as a component of a blood substitute and hemoglobin therapeutics.

摘要翻译： 提供非天然存在的突变体血红蛋白rHb（βN108Q）和rHb（βL105W），其具有比天然血红蛋白低的氧亲和力，但氧结合中的高协同性。 rHb（betaN108Q）也表现出增强的抗氧化稳定性。 突变体血红蛋白优选通过重组DNA技术产生。 这种突变体血红蛋白可以用作血液代用品和血红蛋白治疗剂的组分。

公开(公告)号：US5753465A

公开(公告)日：1998-05-19

申请号：US298339

申请日：1994-08-30

申请人： Chien Ho ,  Tong-Jian Shen

发明人： Chien Ho ,  Tong-Jian Shen

IPC分类号： A61K38/00 ,  C07K14/805 ,  C12N9/48 ,  C12P21/02 ,  C12N15/63

CPC分类号： C07K14/805 ,  C12N9/48 ,  A61K38/00

摘要： Methods for obtaining unmodified recombinant human normal adult hemoglobin involve a novel expression plasmid that coexpresses human .alpha.- and .beta.-globin genes and E. coli methionine aminopeptidase genes under the control of separate tac promoters. Methods are also provided for correcting an abnormal conformation of some of the heme groups incorporated in the proteins expressed by the expression plasmid.

摘要翻译： 用于获得未修饰的重组人正常成人血红蛋白的方法涉及一种新颖的表达质粒，其在单独的tac启动子的控制下共同表达人α-和β-珠蛋白基因和大肠杆菌甲硫氨酸氨基肽酶基因。 还提供了用于校正由表达质粒表达的蛋白质中掺入的一些血红素基团的异常构象的方法。

公开(公告)号：US06808898B2

公开(公告)日：2004-10-26

申请号：US09986667

申请日：2001-11-09

申请人： Chien Ho ,  Ching-Hsuan Tsai ,  Tsuei-Yun Fang ,  Tong-Jian Shen

发明人： Chien Ho ,  Ching-Hsuan Tsai ,  Tsuei-Yun Fang ,  Tong-Jian Shen

IPC分类号： C12P2106

CPC分类号： C07K14/805 ,  A61K38/00

摘要： Non-naturally occurring mutant hemoglobins rHb (&bgr;N108Q) and rHb (&bgr;L105W) are provided that have a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. rHb (&bgr;N108Q) also exhibits enhanced stability against autoxidation. The mutant hemoglobins are preferably produced by recombinant DNA techniques. Such mutant hemoglobins may be used as a component of a blood substitute and hemoglobin therapeutics.