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    SYNTHESIS METHOD OF GLYCO-DRUG RADIOTRACER PRECURSOR
    1.
    发明申请
    SYNTHESIS METHOD OF GLYCO-DRUG RADIOTRACER PRECURSOR 审中-公开
    GLYCO-DRUG RADIOTRACER前体的合成方法

    公开(公告)号：US20140066609A1

    公开(公告)日：2014-03-06

    申请号：US13604353

    申请日：2012-09-05

    申请人： Kuei-Lin LU ,  Yu CHANG ,  Cheng-Fang HSU ,  Mei-Hui WANG ,  Wuu-Jyh LIN

    发明人： Kuei-Lin LU ,  Yu CHANG ,  Cheng-Fang HSU ,  Mei-Hui WANG ,  Wuu-Jyh LIN

    IPC分类号： C07H15/04

    CPC分类号： C07H15/04 ,  C07H1/00 ,  Y02P20/55

    摘要： A novel synthesis method of Glyco-drug radiotracer precursor is revealed. After completing synthesis of Z-Gly-ah (main structure), galactosamine GalNAc(OAc)4 is added to have coupling reaction. Then a product is separated directly from dichloromethane. Thus loss of galactosamine during extraction with liquid chromatography is reduced. Moreover, instead of trifluoroacetyl group, carbobenzoxy (abbreviated as Cbz or Z) is used as a protecting group to ensure uniformity of the phase. The cost and synthesis time are also dramatically reduced.

    摘要翻译： 揭示了一种新型的糖 - 放射性示踪剂前体的合成方法。 完成Z-Gly-ah（主要结构）合成后，加入半乳糖胺GalNAc（OAc）4进行偶联反应。 然后将产物直接从二氯甲烷中分离出来。 因此，用液相色谱法提取过程中半乳糖胺的损失降低。 此外，代替三氟乙酰基，使用苄氧羰基（缩写为Cbz或Z）作为保护基，以确保相的均匀性。 成本和合成时间也大大降低。

    Method to produce a high-purity Zr-89 through physical irradiation and measurement thereof
    2.
    发明申请
    Method to produce a high-purity Zr-89 through physical irradiation and measurement thereof 审中-公开

    公开(公告)号：US20170110211A1

    公开(公告)日：2017-04-20

    申请号：US14882456

    申请日：2015-10-14

    申请人： Ming-Hsin LI ,  Ting-Shien DUH ,  Wuu-Jyh LIN ,  Han-Hsiang CHU

    发明人： Ming-Hsin LI ,  Ting-Shien DUH ,  Wuu-Jyh LIN ,  Han-Hsiang CHU

    IPC分类号： G21G1/00 ,  G21G1/10

    CPC分类号： G21G1/001 ,  G21G1/10 ,  G21G2001/0094

    摘要： A method to produce a high-purity Zr-89 on a solid target through physical irradiation and measurement by selecting a target Barn value of the cross-sectional area of nuclear reaction, drawing a horizontal line to intersect at two points on the function diagram curve and drawing a vertical line downward from each of the two points intersecting at X-axis to obtain incident energy values at the two intersecting points on the X-axis, and followed by plotting an attenuation function diagram curve of penetration depth versus incident energy of Y-89(p,n)Zr-89, selecting an attenuation function diagram curve and a minimum attenuation position of the selected attenuation function diagram curve in correspondence to the incident energy in the interval of incident energy absorption range to obtain an optimal plating thickness value on the solid target.