公开(公告)号：US20160113884A1

公开(公告)日：2016-04-28

申请号：US14522583

申请日：2014-10-24

申请人： Wuu-Jyh Lin ,  Ting-Shien Duh ,  Wei-Ming Li ,  Ming-Hsin Li

发明人： Wuu-Jyh Lin ,  Ting-Shien Duh ,  Wei-Ming Li ,  Ming-Hsin Li

IPC分类号： A61K9/51 ,  A61K31/704

CPC分类号： A61K9/5146 ,  A61K9/5192 ,  A61K31/704

摘要： The preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs includes forming a nanosphere by diselenide block copolymers and DSPE-PEG-biomarkers to coat chemotherapy drugs and/or radiated nanoparticles that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor.

摘要翻译： 用于涂覆辐射纳米颗粒和/或化疗药物的辐射敏感性共聚物载体的制备方法包括通过二硒化物嵌段共聚物和DSPE-PEG-生物标志物形成纳米球，以涂覆可以从开放的纳米球释放的化学药物和/或辐射纳米颗粒， 在质子治疗期间质子穿透组织。 质子治疗的治疗效果通过使用从开放的纳米球释放的辐射纳米颗粒产生核裂变以释放电子以释放肿瘤的肿瘤细胞的质子和从打开的纳米球释放的化疗药物在组织间分布的两种方式得到增强 杀死肿瘤的癌细胞。

公开(公告)号：US08043584B2

公开(公告)日：2011-10-25

申请号：US11812984

申请日：2007-06-22

申请人： Wuu-Jyh Lin ,  Song-Un Tang

发明人： Wuu-Jyh Lin ,  Song-Un Tang

IPC分类号： C22B17/00

CPC分类号： C01G11/00

摘要： Cd-112 isotope is recycled from a Cd-112 chemical separated solution or a remainder of an electroplating solution having a Cd-112 target. The present invention recycles Cd-112 isotope with a low cost, a high purity and a high recycle rate. The recycled Cd-112 isotope can be easily stored. And, the Cd-112 isotope can be used as an imaging agent in nuclear medicine.

公开(公告)号：US08007730B2

公开(公告)日：2011-08-30

申请号：US12478787

申请日：2009-06-05

申请人： Ming-Hsin Li ,  Hsin-EII Wang ,  Chun-Yi Wu ,  Wuu-Jyh Lin

发明人： Ming-Hsin Li ,  Hsin-EII Wang ,  Chun-Yi Wu ,  Wuu-Jyh Lin

IPC分类号： G21C1/00 ,  G05B1/00 ,  G05D16/00 ,  B01J19/00

CPC分类号： B01J19/004

摘要： An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.

摘要翻译： 用于氟-18-乙酸酯（[18 F]氟乙酸酯）的自动合成装置由具有多个反应器和多个原料容器的机械壳体组成，并且在每个反应器和容器之间使用多个控制阀，并通过控制器操作控制阀 系统，以自动和连续的方式从每个容器向每个反应器充填原料，以执行氟化，共沸脱水，合成（与前体反应），纯化和分离，水解和中和，纯化和收集的六个步骤。 该操作只需要事先向容器中加入原料，打开电源，充入反应气体。 50分钟内，生产产品的过程即将完成。 操作非常简单，可以有效提高生产效率。

公开(公告)号：US20100216207A1

公开(公告)日：2010-08-26

申请号：US11979097

申请日：2007-10-30

申请人： Yean-Chang Chen ,  Kuan-Yin Chen ,  Chia-Chieh Chen ,  Bin Lin ,  Hsueh-Hsuan Liu ,  Meng-Chou Lee ,  Wuu-Jyh Lin ,  Ying-Kai Fu ,  Lie-Hang Shen ,  Wen-Song Hwang ,  Ming-Chao Kuo ,  Wei-Hsi Chen ,  Te-Hsing Wu

发明人： Yean-Chang Chen ,  Kuan-Yin Chen ,  Chia-Chieh Chen ,  Bin Lin ,  Hsueh-Hsuan Liu ,  Meng-Chou Lee ,  Wuu-Jyh Lin ,  Ying-Kai Fu ,  Lie-Hang Shen ,  Wen-Song Hwang ,  Ming-Chao Kuo ,  Wei-Hsi Chen ,  Te-Hsing Wu

IPC分类号： C12N13/00 ,  C12M1/12

CPC分类号： C12N1/36 ,  A01G33/00 ,  C12N1/12 ,  C12N13/00 ,  Y02A40/88

摘要： An apparatus is disclosed for growing algae by ionizing radiation. The apparatus includes a container for containing medium for the growth of algae, a filter disposed in the container, a 3-dimensional rack disposed in the container, an adherent element wound on the 3-dimension rack so that spores of the algae can be planted in the adherent element, a radiation element disposed in the container for irradiating the spores and a timepiece connected to the radiation element.

摘要翻译： 公开了通过电离辐射来生长藻类的装置。 该装置包括用于容纳藻类生长的容器的容器，设置在容器中的过滤器，设置在容器中的3维齿条，缠绕在3维齿条上的粘附元件，以便能种植藻类的孢子 在粘合元件中，设置在容器中用于照射孢子的辐射元件和连接到辐射元件的钟表。

公开(公告)号：US20090108018A1

公开(公告)日：2009-04-30

申请号：US11868540

申请日：2007-10-08

申请人： MING-HSIN LI ,  WUU-JYH LIN ,  TAIN-SHI ZEN

发明人： MING-HSIN LI ,  WUU-JYH LIN ,  TAIN-SHI ZEN

IPC分类号： B23Q7/12

CPC分类号： A61J1/2096 ,  B65B3/003 ,  G21G1/0005

摘要： An automated dispenser for radiopharmaceuticals is mainly for a platform to have a moving mechanism being able to move three-dimensionally back and forth, a syringe holder and a bottle holder. The syringe holder is for holding a plural number of syringes. The bottle holder has a reverse drug bottle. The moving mechanism has a syringe clamp rotatable around a horizontal axis and a syringe driving mechanism. The syringe clamp is activated to hold a syringe and move it to where the syringe needle is inserted to the drug bottle. The syringe driving mechanism and the syringe clamp are simultaneously associated with the syringe for drug-withdrawing action.

摘要翻译： 用于放射性药物的自动分配器主要用于具有能够三维来回移动的移动机构的平台，注射器保持器和瓶保持器。 注射器支架用于容纳多个注射器。 瓶架有一个反向药瓶。 移动机构具有可绕水平轴线旋转的注射器夹具和注射器驱动机构。 注射器夹具被启动以保持注射器并将其移动到注射器针头插入药瓶的位置。 注射器驱动机构和注射器夹具同时与注射器相关联用于吸药动作。

公开(公告)号：US20080041719A1

公开(公告)日：2008-02-21

申请号：US11500936

申请日：2006-08-09

申请人： Wuu-Jyh Lin ,  Mao-Hsung Chang ,  Ping-Yen Huang ,  Jenn-Tzong Chen ,  Ting-Shien Duh ,  Dow-Che Chen ,  Kuo-Yuan Chu

发明人： Wuu-Jyh Lin ,  Mao-Hsung Chang ,  Ping-Yen Huang ,  Jenn-Tzong Chen ,  Ting-Shien Duh ,  Dow-Che Chen ,  Kuo-Yuan Chu

IPC分类号： C23C14/00

CPC分类号： H01J37/3497 ,  H01J37/3435

摘要： A liquid and a gas is constantly filled into a target chamber of a target. Then the liquid and the gas flow around the chamber and are flown out. By doing so, the target is effectively cooled down.

摘要翻译： 液体和气体不断地被填充到目标的靶室中。 然后液体和气体流过室并流出。 通过这样做，目标被有效地冷却下来。

公开(公告)号：US20170110211A1

公开(公告)日：2017-04-20

申请号：US14882456

申请日：2015-10-14

申请人： Ming-Hsin LI ,  Ting-Shien DUH ,  Wuu-Jyh LIN ,  Han-Hsiang CHU

发明人： Ming-Hsin LI ,  Ting-Shien DUH ,  Wuu-Jyh LIN ,  Han-Hsiang CHU

IPC分类号： G21G1/00 ,  G21G1/10

CPC分类号： G21G1/001 ,  G21G1/10 ,  G21G2001/0094

摘要： A method to produce a high-purity Zr-89 on a solid target through physical irradiation and measurement by selecting a target Barn value of the cross-sectional area of nuclear reaction, drawing a horizontal line to intersect at two points on the function diagram curve and drawing a vertical line downward from each of the two points intersecting at X-axis to obtain incident energy values at the two intersecting points on the X-axis, and followed by plotting an attenuation function diagram curve of penetration depth versus incident energy of Y-89(p,n)Zr-89, selecting an attenuation function diagram curve and a minimum attenuation position of the selected attenuation function diagram curve in correspondence to the incident energy in the interval of incident energy absorption range to obtain an optimal plating thickness value on the solid target.

公开(公告)号：US09040017B2

公开(公告)日：2015-05-26

申请号：US13243225

申请日：2011-09-23

申请人： Mei-Hui Wang ,  Wuu-Jyh Lin ,  Hung-Man Yu ,  Chuan-Yi Chien ,  Ping-Yen Wang

发明人： Mei-Hui Wang ,  Wuu-Jyh Lin ,  Hung-Man Yu ,  Chuan-Yi Chien ,  Ping-Yen Wang

IPC分类号： A61K51/04 ,  A61K51/06

CPC分类号： A61K51/0491 ,  A61K51/0406 ,  A61K51/0497 ,  A61K51/065

摘要： The present invention is related to a pharmaceutical composition for a liver-receptor imaging injection, the pharmaceutical composition including a bi-functional compound which has a ASGPR specificity, wherein the bi-functional compound includes a backbone of alpha-amino acid (or the derivatives thereof) and a poly-galactosamine chain (or a poly-lactose chain) connected to the alpha-amino acid. Thereby, the pharmaceutical composition can quantify potential of liver storage ability and evaluate severity of the course of liver disease. A liver-receptor imaging injection using the same and the one-step dispensing method thereof are also provided to improve defects of iodine-labeled and overcome disadvantages of the reduced labeling-yield and the instability after autoclave sterilization.

摘要翻译： 本发明涉及一种肝 - 受体成像注射用药物组合物，该药物组合物包含具有ASGPR特异性的双功能化合物，其中双官能化合物包括α-氨基酸（或其衍生物 ）和与α-氨基酸连接的聚半乳糖胺链（或聚乳糖链）。 因此，药物组合物可以量化肝脏储存能力的潜力并评估肝脏疾病过程的严重程度。 还提供使用其的肝受体成像注射器及其一步式分配方法，以改善碘标记的缺陷，克服降压标记产率和高压灭菌后的不稳定性的缺点。

公开(公告)号：US20140046045A1

公开(公告)日：2014-02-13

申请号：US13571731

申请日：2012-08-10

申请人： CHIH-YUAN LIN ,  YU CHANG ,  JEN-TSUNG WANG ,  CHENG-FANG HSU ,  WEI-TI KUO ,  HUNG-WEN YU ,  WUU-JYH LIN ,  MEI-HUI WANG

发明人： CHIH-YUAN LIN ,  YU CHANG ,  JEN-TSUNG WANG ,  CHENG-FANG HSU ,  WEI-TI KUO ,  HUNG-WEN YU ,  WUU-JYH LIN ,  MEI-HUI WANG

IPC分类号： C07H15/04 ,  C07H1/06

CPC分类号： C07H1/06 ,  C07H15/04 ,  C07K1/13

摘要： A method for preparing a precursor used to label hepatocyte receptors is revealed. The precursor contains a bifunctional structure including trisaccharide and DTPA ligand. During synthesis processes of the precursor, silica gel columns and Reverse phase-18 (RP-18) columns are used for purification. Thus both the purification times and cost of each purification are reduced. Moreover, use diethyl ether to facilitate precipitation of products and remove a part of coupling reagent. Removing the coupling reagent helps purification of products. Furthermore, Nα,Nα-bis(carboxymethyl)-L-lysine hydrate and benzyl chloroformate are coupled to form a trisaccharide skeleton so as to ensure the yield rate of trisaccharide structure.

摘要翻译： 揭示了制备用于标记肝细胞受体的前体的方法。 该前体含有包括三糖和DTPA配体的双功能结构。 在前体的合成过程中，使用硅胶柱和反相18（RP-18）柱进行纯化。 因此，每次纯化的纯化时间和成本均降低。 此外，使用乙醚促进产物沉淀并除去一部分偶联剂。 去除偶联剂有助于净化产品。 此外，Nalpha，Nalpha-双（羧甲基）-L-赖氨酸水合物和氯甲酸苄酯偶联形成三糖骨架，以确保三糖结构的产率。

公开(公告)号：US08552163B2

公开(公告)日：2013-10-08

申请号：US12891004

申请日：2010-09-27

申请人： Reiko Takasaka Lee ,  Yuan-Chuan Lee ,  Mei-Hui Wang ,  Wuu-Jyh Lin

发明人： Reiko Takasaka Lee ,  Yuan-Chuan Lee ,  Mei-Hui Wang ,  Wuu-Jyh Lin

IPC分类号： C07H17/02 ,  C07C229/00

CPC分类号： C07H15/04

摘要： This invention provides novel liver targeting agents and their synthetic methods. A liver targeting agent, with a lysine based nitrilotriacetic acid structure as backbone which acquires multivalency with saccharide groups, to bind with a galactosamine chain or lactose chain is disclosed. In particular, only one amino acid L-lysine is involved to provide trivalency. All carboxyl groups in Nε-benzyloxycarbonyl-Nα-dicarboxymethyl-L-lysine can be conjugated with three glycosides of ahGalNAc or ahLac in one step. This invention also provides a hexa-lactoside. In particular, the TFA-AHA-Asp was used to conjugate 2 molecules of NTA(ahLac)3. This invention also provides a method for adding a spacer between NTA and DTPA. The extended hepatocyte-specific glyco-ligand has higher 111In-radiolabelling yield than those non-extended.

摘要翻译： 本发明提供新型肝靶向剂及其合成方法。 公开了以赖氨酸的次氮基三乙酸结构作为骨架的肝靶向剂，其以糖基取代多价，与半乳糖胺链或乳糖链结合。 特别地，仅涉及一个氨基酸L-赖氨酸以提供三价值。 Nepsilon-苄氧基羰基-Nalpha-二羧甲基-L-赖氨酸中的所有羧基可以在一个步骤中与ahGalNAc或ahLac的三种糖苷缀合。 本发明还提供了六乳糖苷。 特别地，TFA-AHA-Asp用于结合2分子的NTA（ahLac）3。 本发明还提供了一种在NTA和DTPA之间添加间隔物的方法。 延长的肝细胞特异性糖配体比未延长的肝细胞特异性糖配体具有更高的111In-放射性标记产率。