Cyclic compound, method for producing cyclic compound, and method for modifying biological molecule
    5.
    发明授权
    Cyclic compound, method for producing cyclic compound, and method for modifying biological molecule 有权
    环状化合物,环状化合物的制造方法以及生物分子修饰方法

    公开(公告)号:US09422294B2

    公开(公告)日:2016-08-23

    申请号:US14338829

    申请日:2014-07-23

    申请人: JNC CORPORATION

    摘要: The invention aims in establishing a method for modifying biomolecules using a reaction that efficiently modifies biomolecules and is widely applicable. The invention thus provides a cyclic compound containing two triazole rings formed by adding and ligating an azide compound possessing an azido group to each of the two carbon-carbon triple bond sites of an eight-membered cyclic skeleton of a cyclic diyne compound by a double click reaction; a method for producing a cyclic compound using a double click reaction; and a method for modifying biomolecules.

    摘要翻译: 本发明旨在建立一种使用有效修饰生物分子的反应来修饰生物分子的方法,并且是广泛适用的。 因此,本发明提供一种环状化合物,其包含通过双键加成并连接具有叠氮基的叠氮化合物与环状二炔化合物的八元环骨架的两个碳 - 碳三键位点形成的两个三唑环 反应; 使用双键反应制备环状化合物的方法; 和一种修饰生物分子的方法。