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公开(公告)号：US20240057572A1
公开(公告)日：2024-02-22
申请号：US17943533
申请日：2022-09-13
申请人： Kymab Limited
发明人： Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang
IPC分类号： A01K67/027 , A61K39/02 , A61K39/35 , C07K16/00 , C07K16/12 , C07K16/18 , C07K16/46 , C12N15/85
CPC分类号： A01K67/0278 , A01K67/0271 , A01K67/0275 , A01K67/0276 , A61K39/107 , A61K39/35 , C07K16/00 , C07K16/1203 , C07K16/1239 , C07K16/18 , C07K16/462 , C12N15/8509 , A01K2207/15 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
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公开(公告)号：US09938357B2
公开(公告)日：2018-04-10
申请号：US15383196
申请日：2016-12-19
申请人： Kymab Limited
发明人： Allan Bradley , E-Chiang Lee , Wei Wang , Qi Liang , Dominik Spensberger , Hui Liu , Jasper Clube
IPC分类号： A01K67/027 , A61K39/395 , C07H21/04 , C12N5/07 , C12N15/63 , C07K16/46 , C12N15/85 , C07K16/18
CPC分类号： C07K16/461 , A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07H21/04 , C07K16/1239 , C07K16/18 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/35 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/63 , C12N15/8509 , C12N2015/8518 , C12N2800/30 , C12N2800/80
摘要： The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanized antibodies; compositions comprising the antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in the methods.
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公开(公告)号：US09505827B2
公开(公告)日：2016-11-29
申请号：US13740727
申请日：2013-01-14
申请人： Kymab Limited
发明人： Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Glenn Friedrich
CPC分类号： A01K67/0278 , A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A61K39/107 , A61K39/35 , A61K2039/505 , C07K16/00 , C07K16/1203 , C07K16/1239 , C07K16/18 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12N15/8509 , C12N2015/8518
摘要： The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanized antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
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公开(公告)号：US09504236B2
公开(公告)日：2016-11-29
申请号：US14935010
申请日：2015-11-06
发明人： Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang
IPC分类号： C12P21/00 , A01K67/027 , C12N5/06 , C12P21/08 , C07K16/46 , C12N15/85 , C07K16/12 , C07K16/18 , C07K16/00
CPC分类号： C07K16/462 , A01K67/0278 , A01K2217/052 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/1239 , C07K16/1282 , C07K16/18 , C07K16/46 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/56 , C07K2317/92 , C12N15/85 , C12N15/8509 , C12N2015/8518
摘要： The invention pertains to a transgenic non-human mammal which contains a chimeric immunoglobulin locus containing human variable region gene segments at an endogenous Ig locus operatively linked to non-human mammalian constant region genes, and methods to produce chimeric antibodies therefrom.
摘要翻译： 本发明涉及一种转基因非人哺乳动物，其含有在与非人哺乳动物恒定区基因可操作连接的内源性Ig基因座处含有人可变区基因片段的嵌合免疫球蛋白基因，以及由其制备嵌合抗体的方法。
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公开(公告)号：US20150113669A1
公开(公告)日：2015-04-23
申请号：US14497054
申请日：2014-09-25
申请人： KYMAB LIMITED
发明人： Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang
IPC分类号： C07K16/18
CPC分类号： A01K67/0278 , A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A61K39/107 , A61K39/35 , A61K2039/505 , C07K16/00 , C07K16/1203 , C07K16/1239 , C07K16/18 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12N15/8509 , C12N2015/8518
摘要： The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
摘要翻译： 本发明公开了产生嵌合人非 - 人抗体和嵌合抗体链，如此产生的抗体和抗体链的方法及其衍生物，包括完全人源化抗体; 包含适合用于所述方法的所述抗体，抗体链和衍生物的组合物，以及细胞，非人哺乳动物和载体。
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公开(公告)号：US20230263143A1
公开(公告)日：2023-08-24
申请号：US18166813
申请日：2023-02-09
申请人： Kymab Limited
发明人： Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Glenn Friedrich
IPC分类号： A01K67/027 , C07K16/12 , C07K16/00 , C07K16/18 , C07K16/46 , A61K39/02 , A61K39/35 , C12N15/85
CPC分类号： A01K67/0278 , C07K16/1239 , C07K16/00 , C07K16/18 , A01K67/0275 , C07K16/1203 , C07K16/462 , A61K39/107 , A61K39/35 , A01K67/0276 , A01K67/0271 , C12N15/8509 , C07K2317/24 , A01K2227/105 , A01K2267/01 , A01K2207/15 , A01K2217/072 , A01K2217/075 , C07K2317/14 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , A01K2217/15 , C07K2317/21 , C07K2317/76 , A61K2039/505
摘要： The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
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公开(公告)号：US20230225302A1
公开(公告)日：2023-07-20
申请号：US18162043
申请日：2023-01-31
申请人： Kymab Limited
发明人： Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Glenn Friedrich
CPC分类号： A01K67/0278 , C07K16/00 , C12N15/8509 , C07K16/462 , C07K16/1239 , C07K16/18 , A01K2217/05 , C07K2317/56 , A01K2207/15 , A01K2217/052 , A01K2227/105 , A01K2267/01 , C07K2317/24 , A01K2217/072 , C07K2317/14 , C07K2317/21 , C07K2317/51 , C07K2317/565 , C07K2317/92
摘要： The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
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公开(公告)号：US11564380B2
公开(公告)日：2023-01-31
申请号：US14818162
申请日：2015-08-04
申请人： Kymab Limited
发明人： Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Glenn Friedrich
摘要： The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
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公开(公告)号：US10815308B2
公开(公告)日：2020-10-27
申请号：US16722452
申请日：2019-12-20
申请人： KYMAB LIMITED
IPC分类号： C07K16/36
摘要： Bispecific antigen binding molecules (e.g., antibodies) that bind blood clotting factors, factor IXa (FIXa) and factor X (FX), and enhance the FIXa-catalysed activation of FX to FXa. Use of the bispecific antigen binding molecules to control bleeding, by replacing natural cofactor FVIIIa which is deficient in patients with haemophilia A.
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公开(公告)号：US20190327946A1
公开(公告)日：2019-10-31
申请号：US16296033
申请日：2019-03-07
申请人： Kymab Limited
发明人： Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
IPC分类号： A01K67/027 , C07K16/12 , C07K16/18 , C07K16/06
摘要： The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising the antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in the methods.
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