公开(公告)号：US20230041245A1

公开(公告)日：2023-02-09

申请号：US17791113

申请日：2020-12-21

申请人： L&C Bio Co., Ltd.

发明人： Dong Hyun Nam ,  Sang Chul Kim ,  Kee Won Lee ,  Hyung Gu Kim ,  Whan Chul Lee

IPC分类号： A61L27/36 ,  C12N5/071

摘要： The present invention relates to a decellularized nerve graft using allogeneic and heterologous nervous tissues and a method of manufacturing the same.
In the present invention, by using a low-concentration basic solution and a surfactant as a decellularization solution, cell and tissue toxicity caused by a solvent or surfactant remaining in the tissue may be minimized by minimizing the use of a basic solution and an anionic surfactant in the entire manufacturing process. In addition, a peristaltic pump may be used to maintain the tissue structure and effectively remove lipid and cells.

公开(公告)号：US20240226233A1

公开(公告)日：2024-07-11

申请号：US18558382

申请日：2021-05-03

申请人： L&C BIO CO., LTD.

发明人： Dong Hyun Nam ,  Kee Won Lee ,  Hyung Gu Kim ,  Whan Chul Lee

IPC分类号： A61K38/17 ,  A61K8/64 ,  A61K38/10 ,  A61P17/02 ,  A61Q19/00

CPC分类号： A61K38/1709 ,  A61K8/64 ,  A61K38/10 ,  A61P17/02 ,  A61Q19/00

摘要： The present invention relates to a zinc-alpha-2-glycoprotein (ZAG)-derived peptide and a use thereof. The ZAG protein-derived peptide according to the present invention can be used to prevent, treat, or improve scars by suppressing cell migration and reducing the expression of RNA and proteins associated with the formation of scars.