公开(公告)号：US09795551B2

公开(公告)日：2017-10-24

申请号：US14315585

申请日：2014-06-26

Applicant: L'OREAL

Inventor： Jean-Marc Sabatier ,  Zhi Pan

IPC: A61K38/00 ,  A61K8/64 ,  C07K5/117 ,  A61Q19/00 ,  A61Q5/00 ,  A23L3/3544 ,  C07K5/09 ,  A23L3/3526

CPC classification number: A61K8/64 ,  A23L3/3526 ,  A23L3/3544 ,  A23V2002/00 ,  A61K2800/10 ,  A61K2800/522 ,  A61Q5/00 ,  A61Q11/00 ,  A61Q19/00 ,  C07K5/0817 ,  C07K5/1024

Abstract: A tetrapeptide having antioxidant activity is provided. The tetrapeptide has a structure comprising, in amino acid sequence from N-terminus to C-terminus: tryptophan-X-tyrosine-X; wherein X is arginine, lysine, histidine or any positively-charged amino acid derivative such as 5-hydroxylysine, ornithine, 2,4-diamino-butyrate and 2,3-diamino-propionate. Each amino acid of the sequence or its Homo-amino acid derivative is independently of the D configuration (D-stereoisomer) or of the L configuration (L-stereoisomer), and the C-terminal comprises one selected from the group consisting of carboxyl (—COOH), and carboxamide (—CONH2). A composition stabilized to oxidation or having antioxidant activity and a method for attenuating effects of free radicals on a keratinous material are also provided.