公开(公告)号：US20230265511A1

公开(公告)日：2023-08-24

申请号：US18002270

申请日：2021-06-30

Applicant: L'OREAL

Inventor： Yann MAHE ,  Khalid BAKKAR ,  Elias BOU SAMRA

IPC: C12Q1/6883

CPC classification number: C12Q1/6883 ,  C12Q1/6869 ,  C12Q2600/158

Abstract: The present invention relates to a method for the in vitro prognosis and/or diagnosis of a common alopecic state of the scalp in a subject, comprising at least one step a) of measuring the expression level, in a biological sample from an area suspected of being an alopecic area or of becoming an alopecic area in said subject, of at least one gene involved in the intercellular junctions of the scalp and/or of the hair follicle chosen from CDH1, ACTB, ACTBL2, TUBB, TUBB2A, GSN, MYO3B, MYO5B, MYO6, DSG2, DSG3, DSG4, DSC2, GJB2, GJA1, GJB6, GJA3, TJP2, CLDN8, CLDN10, CLDN19, and optionally of at least one gene chosen from CTNNB1 and CTNND2, wherein said common alopecic state is chosen from androgenetic alopecia, traction alopecia, female pattern hair loss, cicatricial alopecia, telogen effluvium, stress-related alopecia, seasonal alopecia, age-related alopecia and micro-inflammatory alopecia.
The invention also relates to an in vitro method for evaluating the efficacy of a treatment of a common alopecic state, to a cosmetic treatment method, to the use of a modulator of said abovementioned gene(s), and also to a method for identifying a compound which allows the prevention and/or treatment of a common alopecic state.

公开(公告)号：US20160074353A1

公开(公告)日：2016-03-17

申请号：US14890064

申请日：2014-05-07

Applicant: L'OREAL ,  NESTEC SA

Inventor： Yann MAHE ,  Carole BRU ,  Audrey GUENICHE

IPC: A61K31/201 ,  A61K31/315 ,  A61K31/01 ,  A61K31/145

CPC classification number: A61K31/201 ,  A61K8/36 ,  A61K8/97 ,  A61K31/01 ,  A61K31/145 ,  A61K31/198 ,  A61K31/23 ,  A61K31/315 ,  A61K33/30 ,  A61K2800/92 ,  A61Q19/00 ,  A61Q19/06 ,  A61K2300/00

Abstract: The present invention concerns the cosmetic use, by oral administration, of petroselinic acid or of a combination of active ingredients comprising at least petroselinic acid and at least one compound chosen from zinc, taurine, one of the salts of same, lycopene and the mixtures thereof, and preferably at least taurine or zinc gluconate and, more preferably still, at least taurine and zinc gluconate, with the aim of fighting against aesthetic disorders of the body figure linked to modifications in the adipose tissue.

Abstract translation: 本发明涉及通过口服给药的岩芹酸的化妆品用途或至少包含岩芹酸和至少一种选自锌，牛磺酸，其中一种盐，番茄红素及其混合物的化合物的组合的组合 ，并且优选至少为牛磺酸或葡萄糖酸锌，更优选至少为至少牛磺酸和葡萄糖酸锌，目的是防止与脂肪组织中的修饰连接的身体图形的美学障碍。

公开(公告)号：US20240024226A1

公开(公告)日：2024-01-25

申请号：US18256491

申请日：2021-12-17

Applicant: L'OREAL

Inventor： Pascal HILAIRE ,  Yann MAHE ,  Francis PRUCHE ,  Gayané AZADIGUIAN ,  Muriel BAYER-VANMOEN ,  Richard MARTIN

IPC: A61K8/99 ,  A61K8/64 ,  A61K8/9789 ,  A61K8/19 ,  A61Q19/00

CPC classification number: A61K8/99 ,  A61K8/64 ,  A61K8/9789 ,  A61K8/19 ,  A61Q19/00

Abstract: The present invention relates to an extract of bacterium of Sphingomonas genus, compositions comprising at least one bacterium of Sphingomonas genus or said extract, the uses thereof, as well as their implementations in cosmetic methods.