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    LASER DESORPTION IONIZATION MASS SPECTROMETRY USING A PARTICULATE SEPARATION BED
    1.
    发明申请
    LASER DESORPTION IONIZATION MASS SPECTROMETRY USING A PARTICULATE SEPARATION BED 有权
    使用颗粒分离床的激光吸附离子质谱

    公开(公告)号：US20150279648A1

    公开(公告)日：2015-10-01

    申请号：US14668485

    申请日：2015-03-25

    Applicant: LI-COR, Inc.

    Inventor： Michael D. Furtaw ,  Jon P. Anderson ,  Mary J. Wirth ,  Robert E. Birdsall ,  Yimin Hua ,  Zhaorui Zhang

    IPC: H01J49/16 ,  H01J49/00

    CPC classification number: H01J49/164 ,  H01J49/0027 ,  H01J49/0418

    Abstract: A self-assembled engineered lattice of nanometer-scale silica particles, or other suitable particles generally resembling regularly-sized spheres, is configured in a separation bed for electrophoresis, isoelectric focusing, chromatography, or other voltage-induced separation of analytes. After separation, the analytes are immobilized on the separation bed and then ionized using matrix-assisted laser desorption/ionization (MALDI) for use with a mass spectrometer. The nanoparticles can be coated with polymers that activate to immobilize the analytes or assist with MALDI. The separation can occur in two dimensions.

    Abstract translation: 在电泳，等电聚焦，色谱法或其他电压分离分析物的分离床中配置纳米尺度二氧化硅颗粒或通常类似于规则尺寸的球体的其它合适颗粒的自组装工程晶格。 分离后，将分析物固定在分离床上，然后使用基质辅助激光解吸/电离（MALDI）离子化，用于质谱仪。 纳米颗粒可以用激活固定分析物或辅助MALDI的聚合物涂覆。 分离可以在两个维度上发生。

    Chemiluminescence compact imaging scanner
    2.
    发明授权
    Chemiluminescence compact imaging scanner 有权
    化学发光成像扫描仪

    公开(公告)号：US08722346B2

    公开(公告)日：2014-05-13

    申请号：US13919877

    申请日：2013-06-17

    Applicant: Li-Cor, Inc.

    Inventor： Ahmed Bouzid ,  Chris Lesiak ,  Daniel W. Konz ,  David L. Franzen ,  William Biggs ,  Jon P. Anderson

    IPC: G01N33/53 ,  G01J1/04

    CPC classification number: C12Q1/6825 ,  G01J1/0403 ,  G01N21/62 ,  G01N21/6486 ,  G01N21/76 ,  G01N33/53 ,  G01N33/5302 ,  G01N33/54373 ,  H04N1/1017 ,  H04N1/191 ,  H04N1/1933

    Abstract: Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars of linear charge-coupled device (CCD) or complementary metal oxide semiconductor (CMOS) imaging chips, and high working numerical aperture (NA) optics scans closely over a sample in one direction and then the opposite direction. Averages or other combinations of intensity readings for each pixel location (x, y) between the two or more passes are averaged together in order to compensate for luminescence that varies over time. On-chip pixel binning and multiple clock frequencies can be used to maximize the signal to noise ratio in a CCD-based scanner.

    Abstract translation: 公开了用于精确地成像化学发光和其它发光的系统，装置和方法。 一种紧凑的平板扫描器，具有不透光的外壳，一个或多个线性电荷耦合器件（CCD）或互补金属氧化物半导体（CMOS）成像芯片的检测棒，以及高工作数值孔径（NA）光学器件密切扫描 在一个方向上的样品上，然后是相反的方向。 将两个或更多遍之间的每个像素位置（x，y）的强度读数的平均值或其他组合平均在一起以便补偿随时间变化的发光。 可以使用片上像素分档和多个时钟频率来最大化基于CCD的扫描仪中的信噪比。

    Laser desorption ionization mass spectrometry using a particulate separation bed
    3.
    发明授权
    Laser desorption ionization mass spectrometry using a particulate separation bed 有权
    使用颗粒分离床的激光解吸电离质谱法

    公开(公告)号：US09595430B2

    公开(公告)日：2017-03-14

    申请号：US14668485

    申请日：2015-03-25

    Applicant: LI-COR, Inc.

    Inventor： Michael D. Furtaw ,  Jon P. Anderson ,  Mary J. Wirth ,  Robert E. Birdsall ,  Yimin Hua ,  Zhaorui Zhang

    IPC: H01J49/16 ,  H01J49/00

    CPC classification number: H01J49/164 ,  H01J49/0027 ,  H01J49/0418

    Abstract: A self-assembled engineered lattice of nanometer-scale silica particles, or other suitable particles generally resembling regularly-sized spheres, is configured in a separation bed for electrophoresis, isoelectric focusing, chromatography, or other voltage-induced separation of analytes. After separation, the analytes are immobilized on the separation bed and then ionized using matrix-assisted laser desorption/ionization (MALDI) for use with a mass spectrometer. The nanoparticles can be coated with polymers that activate to immobilize the analytes or assist with MALDI. The separation can occur in two dimensions.

    Abstract translation: 在电泳，等电聚焦，色谱法或其他电压分离分析物的分离床中配置纳米尺度二氧化硅颗粒或通常类似于规则尺寸的球体的其它合适颗粒的自组装工程晶格。 分离后，将分析物固定在分离床上，然后使用基质辅助激光解吸/电离（MALDI）离子化，用于质谱仪。 纳米颗粒可以用激活固定分析物或辅助MALDI的聚合物涂覆。 分离可以在两个维度上发生。

    CHEMILUMINESCENCE COMPACT IMAGING SCANNER
    4.
    发明申请
    CHEMILUMINESCENCE COMPACT IMAGING SCANNER 审中-公开

    公开(公告)号：US20140206568A1

    公开(公告)日：2014-07-24

    申请号：US14223672

    申请日：2014-03-24

    Applicant: LI-COR, Inc.

    Inventor： Ahmed Bouzid ,  Chris Lesiak ,  Daniel W. Konz ,  David L. Franzen ,  William Biggs ,  Jon P. Anderson

    IPC: G01N21/76 ,  C12Q1/68 ,  G01N21/62 ,  G01N33/543

    CPC classification number: C12Q1/6825 ,  G01J1/0403 ,  G01N21/62 ,  G01N21/6486 ,  G01N21/76 ,  G01N33/53 ,  G01N33/5302 ,  G01N33/54373 ,  H04N1/1017 ,  H04N1/191 ,  H04N1/1933

    Abstract: Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars of linear charge-coupled device (CCD) or complementary metal oxide semiconductor (CMOS) imaging chips, and high working numerical aperture (NA) optics scans closely over a sample in one direction and then the opposite direction. Averages or other combinations of intensity readings for each pixel location (x, y) between the two or more passes are averaged together in order to compensate for luminescence that varies over time. On-chip pixel binning and multiple clock frequencies can be used to maximize the signal to noise ratio in a CCD-based scanner.

    Abstract translation: 公开了用于精确地成像化学发光和其它发光的系统，装置和方法。 一种紧凑的平板扫描器，具有不透光的外壳，一个或多个线性电荷耦合器件（CCD）或互补金属氧化物半导体（CMOS）成像芯片的检测棒，以及高工作数值孔径（NA）光学器件密切扫描 在一个方向上的样品上，然后是相反的方向。 将两个或更多遍之间的每个像素位置（x，y）的强度读数的平均值或其他组合平均在一起以便补偿随时间变化的发光。 可以使用片上像素分档和多个时钟频率来最大化基于CCD的扫描仪中的信噪比。

    CHEMILUMINESCENCE COMPACT IMAGING SCANNER
    7.
    发明申请
    CHEMILUMINESCENCE COMPACT IMAGING SCANNER 有权

    公开(公告)号：US20130280737A1

    公开(公告)日：2013-10-24

    申请号：US13919877

    申请日：2013-06-17

    Applicant: Li-Cor, Inc.

    Inventor： Ahmed Bouzid ,  Chris Lesiak ,  Daniel W. Konz ,  David L. Franzen ,  William Biggs ,  Jon P. Anderson

    IPC: G01N21/64

    CPC classification number: C12Q1/6825 ,  G01J1/0403 ,  G01N21/62 ,  G01N21/6486 ,  G01N21/76 ,  G01N33/53 ,  G01N33/5302 ,  G01N33/54373 ,  H04N1/1017 ,  H04N1/191 ,  H04N1/1933

    Abstract: Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars of linear charge-coupled device (CCD) or complementary metal oxide semiconductor (CMOS) imaging chips, and high working numerical aperture (NA) optics scans closely over a sample in one direction and then the opposite direction. Averages or other combinations of intensity readings for each pixel location (x, y) between the two or more passes are averaged together in order to compensate for luminescence that varies over time. On-chip pixel binning and multiple clock frequencies can be used to maximize the signal to noise ratio in a CCD-based scanner.

    Abstract translation: 公开了用于精确地成像化学发光和其它发光的系统，装置和方法。 一种紧凑的平板扫描器，具有不透光的外壳，一个或多个线性电荷耦合器件（CCD）或互补金属氧化物半导体（CMOS）成像芯片的检测棒，以及高工作数值孔径（NA）光学器件密切扫描 在一个方向上的样品上，然后是相反的方向。 将两个或更多遍之间的每个像素位置（x，y）的强度读数的平均值或其他组合平均在一起以便补偿随时间变化的发光。 可以使用片上像素分档和多个时钟频率来最大化基于CCD的扫描仪中的信噪比。

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