公开(公告)号：US10758631B2

公开(公告)日：2020-09-01

申请号：US15951911

申请日：2018-04-12

Applicant: LI-COR, Inc.

Inventor： Vassil Elitzin ,  William M. Volcheck ,  Katie Schaepe ,  Rahul Patil

IPC: A61K49/00 ,  C09B23/01 ,  A61M5/00 ,  C09B23/08 ,  A61B5/20 ,  A61B5/00

Abstract: Polymorphs of Formula I, which is 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate and methods of making are provided.A method for organ imaging, comprising administering to a subject, a diagnostic effective amount of a composition comprising a polymorph of Formula I are also provided. In one embodiment, the organ includes one or more of kidney, bladder, ureter, urethra, bile ducts, liver, and gall bladder.

公开(公告)号：US20180296704A1

公开(公告)日：2018-10-18

申请号：US15951911

申请日：2018-04-12

Applicant: LI-COR, Inc.

Inventor： Vassil Elitzin ,  William M. Volcheck ,  Katie Schaepe ,  Rahul Patil

IPC: A61K49/00 ,  C09B23/01 ,  A61B5/00 ,  A61B5/20 ,  A61M5/00

CPC classification number: A61K49/0032 ,  A61B5/0071 ,  A61B5/201 ,  A61B2505/05 ,  A61K49/0063 ,  A61M5/007 ,  C09B23/0025 ,  C09B23/0066 ,  C09B23/0075 ,  C09B23/086

Abstract: Polymorphs of Formula I, which is 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate and methods of making are provided.A method for organ imaging, comprising administering to a subject, a diagnostic effective amount of a composition comprising a polymorph of Formula I are also provided. In one embodiment, the organ includes one or more of kidney, bladder, ureter, urethra, bile ducts, liver, and gall bladder.