公开(公告)号：US20240341689A1

公开(公告)日：2024-10-17

申请号：US18755947

申请日：2024-06-27

Applicant: Cardiac Pacemakers, Inc.

Inventor： Qi An ,  Jeffrey E. Stahmann ,  Pramodsingh Hirasingh Thakur ,  Viktoria A. Averina ,  Keith R. Maile

IPC: A61B5/00 ,  A61B5/02 ,  A61B5/0205 ,  A61B5/20 ,  G16H20/10 ,  G16H20/30 ,  G16H40/63 ,  G16H50/30 ,  G16H50/70 ,  A61B5/08

CPC classification number: A61B5/686 ,  A61B5/0031 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/201 ,  A61B5/4836 ,  A61B5/7225 ,  A61B5/725 ,  A61B5/7275 ,  G16H20/10 ,  G16H20/30 ,  G16H40/63 ,  G16H50/30 ,  G16H50/70 ,  A61B5/08

Abstract: Systems and methods for monitoring patients with a chronic disease such as heart failure are disclosed. The system may include a physiological sensor circuit to sense physiological signals and generate signal metrics from the physiological signals. The system may include a health status analyzer circuit to use the signal metrics to generate one or more stability indicators of patient health status, such as stability of heart failure status. The system may additionally generate one or more health status indicators indicating patient health status such as heart failure progression. A patient disposition decision may be generated using the health status indicators and the stability indicators to provide an indication of readiness for patient discharge from or a risk of admission to a hospital.

公开(公告)号：US12076089B2

公开(公告)日：2024-09-03

申请号：US17814757

申请日：2022-07-25

Applicant: Medtronic Ireland Manufacturing Unlimited Company

Inventor： Paul J. Coates ,  Douglas A. Hettrick

IPC: A61B34/10 ,  A61B5/00 ,  A61B5/0536 ,  A61B5/055 ,  A61B5/20 ,  A61B6/03 ,  A61B6/46 ,  A61B6/50 ,  A61B8/08 ,  A61B18/00 ,  A61B18/06 ,  A61B18/14 ,  A61B18/24 ,  A61B34/00 ,  A61B90/00 ,  G16H50/50 ,  A61B6/00 ,  A61B6/12 ,  A61B8/00 ,  A61B17/32 ,  A61B18/02 ,  A61B18/18 ,  A61B34/20

CPC classification number: A61B34/10 ,  A61B5/0066 ,  A61B5/0536 ,  A61B5/055 ,  A61B5/201 ,  A61B5/40 ,  A61B5/4041 ,  A61B5/4047 ,  A61B5/4052 ,  A61B5/407 ,  A61B6/032 ,  A61B6/037 ,  A61B6/461 ,  A61B6/506 ,  A61B8/0891 ,  A61B18/06 ,  A61B18/1492 ,  A61B18/24 ,  A61B34/25 ,  A61B90/37 ,  G16H50/50 ,  A61B6/00 ,  A61B6/12 ,  A61B6/465 ,  A61B8/0841 ,  A61B8/085 ,  A61B8/461 ,  A61B2017/320069 ,  A61B2018/00351 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/1435 ,  A61B2018/1861 ,  A61B2034/104 ,  A61B2034/107 ,  A61B34/20 ,  A61B2090/3735 ,  A61B2090/374 ,  A61B2090/376 ,  A61B2090/3762 ,  A61B2090/378 ,  A61B2090/3954 ,  A61B2090/3958 ,  A61B2090/3966

Abstract: Example systems and techniques for denervation, for example, renal denervation. In some examples, a processor determines one or more tissue characteristics of tissue proximate a target nerve and a blood vessel. The processor may generate, based on the one or more tissue characteristics, an estimated volume of influence of denervation therapy delivered by a therapy delivery device disposed within the blood vessel. The processor may generate a graphical user interface including a graphical representation of the tissue proximate the target nerve and the blood vessel and a graphical representation of the estimated volume of influence.

公开(公告)号：US20240225507A1

公开(公告)日：2024-07-11

申请号：US18436584

申请日：2024-02-08

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Tim A. Fischell ,  Vartan Ghazarossian ,  Steven Almany ,  Michael Sasha John

IPC: A61B5/24 ,  A61B5/00 ,  A61B5/20 ,  A61B17/00 ,  A61B17/32 ,  A61B18/00 ,  A61B18/02 ,  A61B18/04 ,  A61B18/12 ,  A61B18/14 ,  A61B18/18 ,  A61B90/00 ,  A61M25/00

CPC classification number: A61B5/24 ,  A61B5/4035 ,  A61B5/6848 ,  A61B5/6852 ,  A61B18/1492 ,  A61B5/201 ,  A61B2017/00039 ,  A61B17/320068 ,  A61B2017/320069 ,  A61B2018/00214 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00541 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00666 ,  A61B2018/00738 ,  A61B2018/00779 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00827 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00898 ,  A61B2018/00916 ,  A61B2018/0212 ,  A61B18/0218 ,  A61B2018/046 ,  A61B2018/048 ,  A61B18/1233 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61B18/1477 ,  A61B18/1815 ,  A61B2090/376 ,  A61B2090/3966 ,  A61M2025/0095

Abstract: An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

公开(公告)号：US11830613B2

公开(公告)日：2023-11-28

申请号：US17201420

申请日：2021-03-15

Applicant: Physio-Control, Inc.

Inventor： Robert G. Walker ,  Tyson G. Taylor ,  Alexander Esibov ,  Mitchell A. Smith

IPC: G16H40/63 ,  G16H10/60 ,  G16H40/67 ,  G16H10/40 ,  G16H80/00 ,  A61N1/39 ,  G16H50/20 ,  A61B5/00 ,  A61B5/20 ,  G16H50/30 ,  A61B5/145

CPC classification number: G16H40/63 ,  A61B5/201 ,  A61B5/7275 ,  A61N1/3925 ,  G16H10/40 ,  G16H10/60 ,  G16H40/67 ,  G16H50/20 ,  G16H80/00 ,  A61B5/14546 ,  G16H50/30

Abstract: A prehospital telemedicine system comprises a physiologic monitor; an electronic patient care reporting system (ePCR) system; and a point-of-care blood analyzer communicatively coupled to the physiologic monitor and the ePCR system. The point-of-care blood analyzer is configured to perform an analysis of a blood sample based on an indication of a need for a specific blood analysis provided by one of the physiologic monitor and the ePCR system, and to automatically transmit a result of the analysis to a remote data receiving system. The indication of a need for a specific blood analysis may be based upon any one of the following: vital signs data obtained for a patient by the physiologic monitor; and/or current documentation or past medical history captured on or available through the ePCR system.

公开(公告)号：US11806457B2

公开(公告)日：2023-11-07

申请号：US16674532

申请日：2019-11-05

Applicant: Medtronic, Inc.

Inventor： Martin T. Gerber ,  Christopher M. Hobot

IPC: A61M1/28 ,  G16H20/40 ,  A61B5/20

CPC classification number: A61M1/285 ,  G16H20/40 ,  A61B5/201 ,  A61M2205/3303 ,  A61M2205/3334 ,  A61M2205/50 ,  A61M2230/20 ,  A61M2230/201

Abstract: The invention relates to devices, systems, and methods for measuring dialysis adequacy in patients undergoing peritoneal dialysis treatment. The devices, systems, and methods use one or more flow sensors and one or more solute sensors to measure the concentration of a uremic solute and volume of the peritoneal dialysate removed from the patient, and to calculate the dialysis adequacy based on the measured peritoneal dialysate concentration and volume.

公开(公告)号：US20230218216A1

公开(公告)日：2023-07-13

申请号：US18180636

申请日：2023-03-08

Applicant: Otsuka Medical Devices Co., Ltd.

Inventor： Jin Shimada ,  Harry A. Puryear

IPC: A61B5/24 ,  A61B18/18 ,  A61N1/18 ,  A61B5/00 ,  A61B18/14 ,  A61B5/20 ,  A61B18/00 ,  A61B18/16 ,  A61B18/12

CPC classification number: A61B5/24 ,  A61B18/1815 ,  A61N1/18 ,  A61B5/4836 ,  A61B18/1492 ,  A61B5/725 ,  A61B5/201 ,  A61B2018/00511 ,  A61B2018/00404 ,  A61B2018/00839 ,  A61B2018/00023 ,  A61B2018/1467 ,  A61B2018/162 ,  A61B2018/1253 ,  A61B2018/00434 ,  A61B2018/00577 ,  A61B2018/1861 ,  A61B2018/1407 ,  A61B2018/126 ,  A61B2562/028 ,  A61B2018/00267

Abstract: An intraluminal microneurography probe has a probe body configured to be introduced into an artery near an organ of a body without preventing the flow of blood through the artery. An expandable sense electrode and an expandable stimulation electrode are fixed to the probe body at one end of each electrode such that movement of the other end toward the fixed end causes the sense electrode to expand from the probe body toward a wall of the artery. A ground electrode is configured to couple to the body, and a plurality of electrical connections are operable to electrically couple the electrodes to electrical circuitry. The sense electrode is operable to measure sympathetic nerve activity in response to excitation of the stimulation electrode. A radio frequency ablation element is located between the expandable sense electrode and expandable stimulation electrode, and is operable to ablate nerves proximate to the artery.

公开(公告)号：US20230210593A1

公开(公告)日：2023-07-06

申请号：US18109258

申请日：2023-02-13

Applicant: SYMAP MEDICAL (SUZHOU), LIMITED

Inventor： Jie WANG

IPC: A61B18/14 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/20 ,  A61B5/24

CPC classification number: A61B18/1492 ,  A61B5/6853 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/201 ,  A61B5/4833 ,  A61B5/4893 ,  A61B5/0036 ,  A61B5/24 ,  A61B5/7246 ,  A61B5/6852 ,  A61B2018/00202

Abstract: Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The methods includes evaluating a change in physiological parameters after energy is delivered to an arterial wall; and determining the type of nerve that the energy was directed to (sympathetic or parasympathetic or none) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using said method. Also provided are catheters for performing the mapping and ablating functions.

公开(公告)号：US20190192855A1

公开(公告)日：2019-06-27

申请号：US16231154

申请日：2018-12-21

Applicant: Pacesetter, Inc.

Inventor： Rupinder Bharmi ,  Stuart Rosenberg ,  Ryan Rooke ,  Edward Karst ,  Taraneh Ghaffari Farazi

IPC: A61N1/36 ,  A61B18/14 ,  A61B5/145 ,  A61B5/02 ,  A61B5/00

CPC classification number: A61N1/36053 ,  A61B5/02 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/0215 ,  A61B5/14503 ,  A61B5/14535 ,  A61B5/14542 ,  A61B5/201 ,  A61B5/4035 ,  A61B5/486 ,  A61B18/1492 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61N1/36014 ,  A61N1/36121 ,  A61N1/36125 ,  A61N1/36139

Abstract: Described herein are methods, devices, and systems for treating human anemia. The methods, devices, and systems generally include monitoring a patient's hemoglobin level and at least one of autonomic balance and inflammatory state to determine the etiology of the anemic state, modulating at least one of a sympathetic or parasympathetic nerve based on the cause of the anemia, monitoring for changes in the patient's cardiac activity and state of inflammation, and hemoglobin level. An external neurostimulation system is describes, and well as a chronic implantable system. A method for treating a patient for anemia in conjunction with a renal denervation ablation catheter is also disclosed.

公开(公告)号：US20190015002A1

公开(公告)日：2019-01-17

申请号：US16034854

申请日：2018-07-13

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Tim A. Fischell ,  Vartan Ghazarossian ,  Steven Almany ,  Michael Sasha John

IPC: A61B5/04 ,  A61B5/00 ,  A61B18/14 ,  A61B18/04 ,  A61B18/02 ,  A61B18/00 ,  A61B17/00 ,  A61B18/18 ,  A61B18/12 ,  A61B17/32 ,  A61B5/20 ,  A61B90/00 ,  A61M25/00

CPC classification number: A61B5/04001 ,  A61B5/201 ,  A61B5/4035 ,  A61B5/6848 ,  A61B5/6852 ,  A61B18/0218 ,  A61B18/1233 ,  A61B18/1477 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2017/00039 ,  A61B2017/320069 ,  A61B2018/00214 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00541 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00666 ,  A61B2018/00738 ,  A61B2018/00779 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00827 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00898 ,  A61B2018/00916 ,  A61B2018/0212 ,  A61B2018/046 ,  A61B2018/048 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61B2090/376 ,  A61B2090/3966 ,  A61M2025/0095

Abstract: An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

公开(公告)号：US20180353626A1

公开(公告)日：2018-12-13

申请号：US16101544

申请日：2018-08-13

Applicant: NATIONAL UNIVERSITY CORPORATION MIE UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY

Inventor： Katsunori TERANISHI ,  Hitoshi HIRATA ,  Tetsuya ARAI

IPC: A61K49/00 ,  A61B5/0205 ,  A61B5/20 ,  C09B23/08 ,  C09B23/01 ,  C08B37/16 ,  A61M5/00 ,  C09B67/00 ,  A61B5/00 ,  A61B5/026 ,  A61B5/0275

CPC classification number: A61K49/0054 ,  A61B5/0071 ,  A61B5/0205 ,  A61B5/026 ,  A61B5/0275 ,  A61B5/201 ,  A61B5/415 ,  A61B5/418 ,  A61B5/7275 ,  A61B5/7425 ,  A61B2576/00 ,  A61K49/001 ,  A61K49/0017 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0093 ,  A61M5/007 ,  C08B37/0012 ,  C08B37/0015 ,  C09B23/0066 ,  C09B23/086 ,  C09B68/41 ,  C09B68/485

Abstract: The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.