公开(公告)号：US20190192855A1

公开(公告)日：2019-06-27

申请号：US16231154

申请日：2018-12-21

申请人： Pacesetter, Inc.

发明人： Rupinder Bharmi ,  Stuart Rosenberg ,  Ryan Rooke ,  Edward Karst ,  Taraneh Ghaffari Farazi

IPC分类号： A61N1/36 ,  A61B18/14 ,  A61B5/145 ,  A61B5/02 ,  A61B5/00

CPC分类号： A61N1/36053 ,  A61B5/02 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/0215 ,  A61B5/14503 ,  A61B5/14535 ,  A61B5/14542 ,  A61B5/201 ,  A61B5/4035 ,  A61B5/486 ,  A61B18/1492 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61N1/36014 ,  A61N1/36121 ,  A61N1/36125 ,  A61N1/36139

摘要： Described herein are methods, devices, and systems for treating human anemia. The methods, devices, and systems generally include monitoring a patient's hemoglobin level and at least one of autonomic balance and inflammatory state to determine the etiology of the anemic state, modulating at least one of a sympathetic or parasympathetic nerve based on the cause of the anemia, monitoring for changes in the patient's cardiac activity and state of inflammation, and hemoglobin level. An external neurostimulation system is describes, and well as a chronic implantable system. A method for treating a patient for anemia in conjunction with a renal denervation ablation catheter is also disclosed.

公开(公告)号：US20190015002A1

公开(公告)日：2019-01-17

申请号：US16034854

申请日：2018-07-13

申请人： Ablative Solutions, Inc.

发明人： David R. Fischell ,  Tim A. Fischell ,  Vartan Ghazarossian ,  Steven Almany ,  Michael Sasha John

IPC分类号： A61B5/04 ,  A61B5/00 ,  A61B18/14 ,  A61B18/04 ,  A61B18/02 ,  A61B18/00 ,  A61B17/00 ,  A61B18/18 ,  A61B18/12 ,  A61B17/32 ,  A61B5/20 ,  A61B90/00 ,  A61M25/00

CPC分类号： A61B5/04001 ,  A61B5/201 ,  A61B5/4035 ,  A61B5/6848 ,  A61B5/6852 ,  A61B18/0218 ,  A61B18/1233 ,  A61B18/1477 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2017/00039 ,  A61B2017/320069 ,  A61B2018/00214 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00541 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00666 ,  A61B2018/00738 ,  A61B2018/00779 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00827 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00898 ,  A61B2018/00916 ,  A61B2018/0212 ,  A61B2018/046 ,  A61B2018/048 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61B2090/376 ,  A61B2090/3966 ,  A61M2025/0095

摘要： An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

公开(公告)号：US20180353626A1

公开(公告)日：2018-12-13

申请号：US16101544

申请日：2018-08-13

申请人： NATIONAL UNIVERSITY CORPORATION MIE UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY

发明人： Katsunori TERANISHI ,  Hitoshi HIRATA ,  Tetsuya ARAI

IPC分类号： A61K49/00 ,  A61B5/0205 ,  A61B5/20 ,  C09B23/08 ,  C09B23/01 ,  C08B37/16 ,  A61M5/00 ,  C09B67/00 ,  A61B5/00 ,  A61B5/026 ,  A61B5/0275

CPC分类号： A61K49/0054 ,  A61B5/0071 ,  A61B5/0205 ,  A61B5/026 ,  A61B5/0275 ,  A61B5/201 ,  A61B5/415 ,  A61B5/418 ,  A61B5/7275 ,  A61B5/7425 ,  A61B2576/00 ,  A61K49/001 ,  A61K49/0017 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0093 ,  A61M5/007 ,  C08B37/0012 ,  C08B37/0015 ,  C09B23/0066 ,  C09B23/086 ,  C09B68/41 ,  C09B68/485

摘要： The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.

公开(公告)号：US20180206772A1

公开(公告)日：2018-07-26

申请号：US15414197

申请日：2017-01-24

申请人： David R. Hall ,  Dan Allen

发明人： David R. Hall ,  Dan Allen

IPC分类号： A61B5/20 ,  G01N33/493 ,  A61B5/145 ,  A61B10/00 ,  A61B5/1477 ,  A61B5/1455

CPC分类号： A61B5/201 ,  A61B5/14507 ,  A61B5/1455 ,  A61B5/1477 ,  A61B5/207 ,  A61B10/007 ,  A61B2562/0271 ,  A61B2562/0295 ,  G01N33/493

摘要： We disclose an in-toilet urinalysis system which includes a system for collection urine and applying the urine to a urine test strip. The system may include an orifice within a toilet bowl which leads into a channel. The channel may be connected to a capillary which has an orifice at each end. Urine may pass through the orifice, into the channel, then may be moved by capillary action through the capillary. A urine test strip dispenser may move reaction pads on a urine test strip to the distal end of the capillary to load the reaction pads with urine. The reaction pads may absorb the urine from the most distal orifice of the capillary. A measurable chemical reaction may occur in the reaction pads in response to urine analytes.

公开(公告)号：US09861315B2

公开(公告)日：2018-01-09

申请号：US14427889

申请日：2013-09-04

申请人： Lohmann GmbH & Co. KG ,  Norbert Gretz ,  Daniel Schock-Kusch

发明人： Norbert Gretz ,  Daniel Schock-Kusch ,  Michael Herbertz ,  Ralf Nittenwilm

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61B5/20 ,  C09J7/02 ,  A61B5/02 ,  A61B5/145 ,  C08K3/04 ,  C09J133/08

CPC分类号： A61B5/6832 ,  A61B5/0071 ,  A61B5/02 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/201 ,  A61B5/4244 ,  A61B5/425 ,  A61B5/6833 ,  A61B2560/0285 ,  A61B2562/12 ,  C08K3/04 ,  C09J7/22 ,  C09J7/38 ,  C09J7/381 ,  C09J133/08 ,  C09J2201/134 ,  C09J2201/606 ,  C09J2205/102 ,  C09J2400/22 ,  C09J2421/00 ,  C09J2433/00 ,  C09J2467/006 ,  C09J2483/00 ,  C09J2483/005

摘要： The present invention pertains to a functional patch to be affixed to the skin, with the aim of measuring metabolic disruptions to organs, and general organ functions, of kidneys, liver, heart, pancreas and muscles (lactate), for example—more particularly it concerns the measurement of the glomerular filtration rate (GFR)—and also to a method for producing a functional patch of this kind.

公开(公告)号：US20170367636A1

公开(公告)日：2017-12-28

申请号：US15536004

申请日：2015-12-21

申请人： RENALSENSE LTD.

发明人： Jack Yehoshua MANTINBAND ,  Mor GRINSTEIN ,  Michael ADLER

IPC分类号： A61B5/20 ,  G01N33/493 ,  A61B5/00

CPC分类号： A61B5/201 ,  A61B5/14507 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/208 ,  A61B5/6852 ,  A61B10/007 ,  G01N33/493

摘要： Described is an apparatus for inline urine analysis comprising a control unit and at least one image capture unit comprising an image sensor and an optical assembly. The apparatus is configured to be coupled with an indwelling urinary catheter or conduit leading from the catheter. Embodiments of the apparatus comprise a dispenser configured to dispense inert or reactive matter into the urine stream to aid in the analysis of properties of the urine and an illumination device configured to illuminate the urine stream. Also described is a system comprising at least one of these apparatuses and at least one image analyzer unit operatively connected to it. The image analyzer unit comprises a processor and software adapted to analyze the captured images to derive information therefrom relating to identification of properties of the urine and/or objects of interest in the urine stream. Embodiments of the system may comprise other peripheral devices.

公开(公告)号：US09820811B2

公开(公告)日：2017-11-21

申请号：US14956350

申请日：2015-12-01

申请人： SYMAP HOLDING LIMITED

发明人： Jie Wang

IPC分类号： A61B18/00 ,  A61B18/14 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/04 ,  A61B5/20 ,  A61B18/18 ,  A61N1/36

CPC分类号： A61B18/1492 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/04001 ,  A61B5/201 ,  A61B5/4833 ,  A61B5/4836 ,  A61B5/4893 ,  A61B5/6853 ,  A61B18/18 ,  A61B2018/00202 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00791 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/1407 ,  A61B2018/1435 ,  A61B2018/1475 ,  A61N1/36117

摘要： Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The methods includes evaluating a change in physiological parameters after energy is delivered to an arterial wall; and determining the type of nerve that the energy was directed to (sympathetic or parasympathetic or none) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using said method. Also provided are catheters for performing the mapping and ablating functions.

公开(公告)号：US09814788B2

公开(公告)日：2017-11-14

申请号：US14062123

申请日：2013-10-24

申请人： PHARMACOPHOTONICS, INC.

发明人： Exing Wang ,  Daniel Meier ,  Robert Bunch ,  Bruce Molitoris ,  Ruben Sandoval ,  Matthew Rubin

IPC分类号： A61B10/00 ,  A61B5/00 ,  A61B8/00 ,  A61K49/00 ,  A61B5/20

CPC分类号： A61K49/0043 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/201 ,  A61B5/412 ,  A61K49/0017 ,  A61K49/0054

摘要： A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.

公开(公告)号：US09770291B2

公开(公告)日：2017-09-26

申请号：US14421869

申请日：2013-08-23

申请人： SYMAP MEDICAL (SUZHOU), LTD

发明人： Jie Wang ,  Chuwu Li ,  Bo Zou ,  Jiancong Wang

IPC分类号： A61B18/14 ,  A61B5/0205 ,  A61B5/20 ,  A61B5/00 ,  A61B5/04 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/053 ,  A61B18/24 ,  A61N7/02 ,  A61B18/00 ,  A61B18/18 ,  A61N1/36 ,  A61N7/00

CPC分类号： A61B18/1492 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/04001 ,  A61B5/0538 ,  A61B5/201 ,  A61B5/4833 ,  A61B5/4836 ,  A61B5/4893 ,  A61B5/6852 ,  A61B5/6853 ,  A61B18/18 ,  A61B18/24 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00708 ,  A61B2018/00791 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61N1/36117 ,  A61N7/02 ,  A61N2007/003 ,  G06F19/00

摘要： A device for mapping and ablating the renal nerves distributed on the renal artery is provided, said device comprising a guide catheter (11), a mapping-ablation catheter (12), a handle (13) and a connector (15). The guide catheter (11) had at least one lumen and a distal end with adjustable curvature. The mapping-ablation catheter (12) is housed in one of the lumens of the guide catheter (11) and its distal end has one or more electrodes (22) and one or more detecting devices (23). The distal end of the mapping-ablation catheter (12) is curved, rotatable, and can be extended out of or retracted into the guide catheter (11). The handle (13) connects the guide catheter (11) and mapping-ablation catheter (12), and comprises one or more controlling components for controlling the movement of the guide catheter (11) and mapping-ablation catheter (12). The connector (15) is designed to supply energy to the electrodes (22).

公开(公告)号：US09750463B2

公开(公告)日：2017-09-05

申请号：US14101663

申请日：2013-12-10

申请人： General Electric Company

发明人： Gokul Swamy ,  Sahika Genc ,  Hariharan Ravishankar ,  Aditya Saha

IPC分类号： A61B5/00 ,  A61B5/08 ,  A61B5/0205 ,  A61B5/145 ,  A61B5/20 ,  A61B5/083 ,  A61B5/021 ,  A61B5/024 ,  A61B5/01

CPC分类号： A61B5/7275 ,  A61B5/002 ,  A61B5/0022 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0816 ,  A61B5/0836 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/201 ,  A61B5/202 ,  A61B5/7203 ,  A61B5/7246 ,  A61B5/7264 ,  A61B5/746 ,  G06F19/00

摘要： Embodiments of the disclosure are directed to a system for analysis of respiratory distress in hospitalized patients. The system performs multi-parametric simultaneous analysis of respiration rate (RR) and pulse oximetry (SpO2) data trends in order to gauge patterns of patient instability pertaining to respiratory distress. Three patterns in SpO2 and RR are used along with LOWESS algorithm and Chauvenets criteria for outlier rejection to obtain robust short term and long term trends in RR and SpO2. Pattern analysis detects the presence of any one of three pattern types proposed. Further, a learning paradigm is introduced to find unknown instances of respiratory distress. This algorithm in conjunction with the learning model allows early detection of respiratory distress in hospital ward and ICU patients.