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公开(公告)号:US10758631B2
公开(公告)日:2020-09-01
申请号:US15951911
申请日:2018-04-12
Applicant: LI-COR, Inc.
Inventor: Vassil Elitzin , William M. Volcheck , Katie Schaepe , Rahul Patil
Abstract: Polymorphs of Formula I, which is 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate and methods of making are provided.A method for organ imaging, comprising administering to a subject, a diagnostic effective amount of a composition comprising a polymorph of Formula I are also provided. In one embodiment, the organ includes one or more of kidney, bladder, ureter, urethra, bile ducts, liver, and gall bladder.
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公开(公告)号:US20180296704A1
公开(公告)日:2018-10-18
申请号:US15951911
申请日:2018-04-12
Applicant: LI-COR, Inc.
Inventor: Vassil Elitzin , William M. Volcheck , Katie Schaepe , Rahul Patil
CPC classification number: A61K49/0032 , A61B5/0071 , A61B5/201 , A61B2505/05 , A61K49/0063 , A61M5/007 , C09B23/0025 , C09B23/0066 , C09B23/0075 , C09B23/086
Abstract: Polymorphs of Formula I, which is 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate and methods of making are provided.A method for organ imaging, comprising administering to a subject, a diagnostic effective amount of a composition comprising a polymorph of Formula I are also provided. In one embodiment, the organ includes one or more of kidney, bladder, ureter, urethra, bile ducts, liver, and gall bladder.
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公开(公告)号:US20200085976A1
公开(公告)日:2020-03-19
申请号:US16687450
申请日:2019-11-18
Applicant: LI-COR, INC.
Inventor: Daniel R. Draney , William M. Volcheck , Katie Schaepe , Vassil Elitzin , Joy Kovar
Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.
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公开(公告)号:US10548991B2
公开(公告)日:2020-02-04
申请号:US14949654
申请日:2015-11-23
Applicant: LI-COR, Inc.
Inventor: Daniel R. Draney , William M. Volcheck , Katie Schaepe , Vassil Elitzin
Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.
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公开(公告)号:US20200078474A1
公开(公告)日:2020-03-12
申请号:US16687479
申请日:2019-11-18
Applicant: LI-COR, INC.
Inventor: Daniel R. Draney , William M. Volcheck , Katie Schaepe , Vassil Elitzin
Abstract: A composition comprising: a polymorphic form of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-ulfonatobutyl)-3H-indol- 1- ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate and an acceptable excipient.
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公开(公告)号:US20130280172A1
公开(公告)日:2013-10-24
申请号:US13836202
申请日:2013-03-15
Applicant: LI-COR, INC.
Inventor: Xinshe Xu , Daniel R. Draney , Mark Cradduck , Lael Cheung , Kousik Kundu , William M. Volcheck
IPC: A61K49/00
CPC classification number: A61K49/0058 , A61K49/0032 , A61K49/0052 , C07D471/04 , C07F9/6561 , C07K19/00 , C08B37/0072 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B69/00 , G01N33/574 , G01N33/58 , G01N33/582
Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
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公开(公告)号:US11167046B2
公开(公告)日:2021-11-09
申请号:US16687450
申请日:2019-11-18
Applicant: LI-COR, INC.
Inventor: Daniel R. Draney , William M. Volcheck , Katie Schaepe , Vassil Elitzin , Joy Kovar
Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.
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公开(公告)号:US09089603B2
公开(公告)日:2015-07-28
申请号:US13836202
申请日:2013-03-15
Applicant: LI-COR, INC.
Inventor: Xinshe Xu , Daniel R. Draney , Mark Cradduck , Lael Cheung , Kousik Kundu , William M. Volcheck
IPC: C07D471/04 , A61K49/00 , C09B23/01 , C09B23/08 , C09B69/00 , G01N33/574 , G01N33/58 , C07F9/6561 , C07K19/00 , C08B37/08
CPC classification number: A61K49/0058 , A61K49/0032 , A61K49/0052 , C07D471/04 , C07F9/6561 , C07K19/00 , C08B37/0072 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B69/00 , G01N33/574 , G01N33/58 , G01N33/582
Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
Abstract translation: 公开了可用于近红外光谱范围内的无创成像的化合物和方法。 呈现式I的花青化合物:其中Q是聚甲炔桥的一部分:还包括式I化合物的生物缀合物,用化合物标记生物分子的方法和成像方法。
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