公开(公告)号：US09119807B2

公开(公告)日：2015-09-01

申请号：US13689530

申请日：2012-11-29

Applicant: Life Technologies AS

Inventor： Tanja Aarvak ,  Anne-Marie Rasmussen ,  Gunnar Kvalheim ,  Walter Gabriell Borelli Piedras ,  Anne Brunsvig

IPC: C12N5/071 ,  C12N5/00 ,  C12N5/02 ,  A61K31/12 ,  C12N5/0783

CPC classification number: C12N5/0637 ,  A61K31/12 ,  A61K35/17 ,  A61K2035/122 ,  C12N5/0636 ,  C12N2501/04 ,  C12N2501/2302 ,  C12N2501/2304 ,  C12N2501/998 ,  C12N2501/999

Abstract: Methods are disclosed for the generation of immunosuppressive regulatory T cells. The methods can include contacting a population of CD4+CD25− T cells with a T cell receptor (TCR)/CD3 activator, a TCR co-stimulator activator, and rapamycin. Kits for the generation of immunosuppressive regulatory T cells, methods of use, and cell populations are also disclosed.

Abstract translation: 公开了用于产生免疫抑制性调节性T细胞的方法。 所述方法可以包括使CD4 + CD25-T细胞群与T细胞受体（TCR）/ CD3激活剂，TCR共刺激因子激活剂和雷帕霉素接触。 还公开了用于产生免疫抑制性调节性T细胞，使用方法和细胞群的试剂盒。

公开(公告)号：US20150175698A1

公开(公告)日：2015-06-25

申请号：US14402463

申请日：2013-03-06

Applicant: LIFE TECHNOLOGIES AS

Inventor： Karoline Schjetne ,  Tanja Aarvak ,  Lars Norderhaug

IPC: C07K16/28 ,  C12N5/0783

CPC classification number: C07K16/2803 ,  C07K16/00 ,  C07K16/2809 ,  C07K16/2896 ,  C07K2317/53 ,  C07K2317/55 ,  C12N5/0636

Abstract: Provided are methods and composition useful in isolating or otherwise preparing a population of target cells. In part, it relates to recombinant antibodies comprising an exogenous proteolytic cleavage site and nucleic acid molecules encoding the antibodies.

Abstract translation: 提供了可用于分离或以其它方式制备靶细胞群体的方法和组合物。 其部分涉及包含外源蛋白水解切割位点和编码抗体的核酸分子的重组抗体。