公开(公告)号：US20150241438A1

公开(公告)日：2015-08-27

申请号：US14402375

申请日：2013-03-14

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Kyle Gee ,  Upinder Singh ,  Aleksey Rukavishnikov ,  Daniel Beacham ,  Shih-Jung Huang ,  Michael Janes ,  Wenjun Zhou ,  Judith Berlier

IPC: G01N33/58 ,  C07D311/90

CPC classification number: C09B11/24 ,  A61K49/0041 ,  C07D311/90 ,  G01N33/5005 ,  G01N33/582 ,  G01N33/84

Abstract: Disclosed herein are compounds, compositions, methods and kits for detecting pH in samples using pH-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting pH in samples either in vitro or in vivo. Also described herein are processes for preparing said dyes for use in the disclosed compositions, methods and kits.

Abstract translation: 本文公开了使用pH敏感荧光染料检测样品中的pH的化合物，组合物，方法和试剂盒。 本文公开的化合物是包含具有一个或多个给电子基团的苯胺部分的新型呫吨衍生物染料，该染料用于在体外或体内检测样品中的pH。 本文还描述了用于制备用于所公开的组合物，方法和试剂盒的所述染料的方法。

公开(公告)号：US20180362766A1

公开(公告)日：2018-12-20

申请号：US15955332

申请日：2018-04-17

Applicant: Life Technologies Corporation

Inventor： Kyle Gee ,  Upinder Singh ,  Aleksey Rukavishnikov ,  Daniel Beacham ,  Shih-Jung Huang ,  Michael Janes ,  Wenjun Zhou ,  Judith Berlier

IPC: C09B11/24 ,  G01N33/84 ,  C07D311/90 ,  A61K49/00 ,  G01N33/58 ,  G01N33/50

Abstract: Disclosed herein are compounds, compositions, methods and kits for detecting pH in samples using pH-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting pH in samples either in vitro or in vivo. Also described herein are processes for preparing said dyes for use in the disclosed compositions, methods and kits.