公开(公告)号：US20140377837A1

公开(公告)日：2014-12-25

申请号：US14299284

申请日：2014-06-09

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Brian AGNEW ,  Kyle Gee ,  Schuyler Corry

IPC: G01N33/58

CPC classification number: C12P21/005 ,  A61K47/549 ,  C07K1/13 ,  C07K14/47 ,  C07K16/00 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/41 ,  C12Y302/01096 ,  G01N33/5005 ,  G01N33/5008 ,  G01N33/531 ,  G01N33/532 ,  G01N33/533 ,  G01N33/534 ,  G01N33/581 ,  G01N33/582 ,  G01N33/583 ,  Y10T436/17

Abstract: The present invention generally relates to methods of functionalizing proteins, particularly antibodies, at oligosaccharide linkages, methods of humanizing antibodies by modifying glycosylation, as well as to novel antibodies linked to modified oligosaccharides. The invention further relates to kits that may be used to produce the antibodies of the invention.

Abstract translation: 本发明通常涉及在寡糖键上官能化蛋白质，特别是抗体的方法，通过修饰糖基化来人源化抗体的方法，以及与修饰的寡糖连接的新型抗体。 本发明还涉及可用于产生本发明抗体的试剂盒。

公开(公告)号：US20140206848A1

公开(公告)日：2014-07-24

申请号：US14221798

申请日：2014-03-21

Applicant: Life Technologies Corporation

Inventor： Brian Agnew ,  Kyle Gee ,  Schuyler Corry

IPC: C12P21/00 ,  G01N33/58 ,  C07K16/00

CPC classification number: C12P21/005 ,  A61K47/549 ,  C07K1/13 ,  C07K14/47 ,  C07K16/00 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/41 ,  C12Y302/01096 ,  G01N33/5005 ,  G01N33/5008 ,  G01N33/531 ,  G01N33/532 ,  G01N33/533 ,  G01N33/534 ,  G01N33/581 ,  G01N33/582 ,  G01N33/583 ,  Y10T436/17

Abstract: The present invention generally relates to methods of functionalizing proteins, particularly antibodies, at oligosaccharide linkages, methods of humanizing antibodies by modifying glycosylation, as well as to novel antibodies linked to modified oligosaccharides. The invention further relates to kits that may be used to produce the antibodies of the invention.

公开(公告)号：US10676771B2

公开(公告)日：2020-06-09

申请号：US15385340

申请日：2016-12-20

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Brian Agnew ,  Kyle Gee ,  Schuyler Corry

IPC: C07K16/00 ,  C07K14/47 ,  G01N33/533 ,  C12P21/00 ,  A61K47/54 ,  G01N33/531 ,  C07K1/13 ,  G01N33/532 ,  G01N33/50 ,  G01N33/58 ,  G01N33/534

Abstract: The present invention generally relates to methods of functionalizing proteins, particularly antibodies, at oligosaccharide linkages, methods of humanizing antibodies by modifying glycosylation, as well as to novel antibodies linked to modified oligosaccharides. The invention further relates to kits that may be used to produce the antibodies of the invention.