公开(公告)号：US12208228B2

公开(公告)日：2025-01-28

申请号：US17436255

申请日：2020-03-06

Applicant: LTS LOHMANN THERAPIE-SYSTEME AG

Inventor： James Paul Ronnander ,  Andreas Koch

IPC: A61M37/00

Abstract: The invention relates to a microneedle array having a heat-generating element and its use for the intradermal application of active ingredients, particularly active pharmaceutical ingredients (API) and drugs, wherein this microneedle array is suitable for skin penetration on humans or animals and the microneedles consist of a water-soluble formulation, which contains at least one active ingredient.

公开(公告)号：US20230417642A1

公开(公告)日：2023-12-28

申请号：US18037227

申请日：2021-11-17

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Helena Gallinger ,  Andreas Koch

IPC: G01N13/00 ,  G01N33/15 ,  G01N1/44 ,  G01K5/48 ,  F28D1/06 ,  G09B23/28 ,  G05D23/19 ,  G05D23/27

CPC classification number: G01N13/00 ,  G01N33/15 ,  G01N1/44 ,  G01K5/48 ,  F28D1/06 ,  G09B23/28 ,  G05D23/1919 ,  G05D23/27 ,  G01N2013/003 ,  G01N2035/00178

Abstract: A temperature control system for a diffusion cell. The temperature control system includes a cell head and a temperature control device connected to the cell head. Moreover, a diffusion cell having such a temperature control system. Furthermore a diffusion cell system having such a temperature control system or such a diffusion cell. Finally, a method for controlling the temperature of a cell head of a diffusion cell, including introducing the temperature control fluid into the cell head.

公开(公告)号：US10881607B2

公开(公告)日：2021-01-05

申请号：US16715972

申请日：2019-12-16

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Christoph Schmitz ,  Mohammad Sameti ,  Andreas Koch ,  Michael Horstmann

IPC: A61K9/00 ,  A61K9/70 ,  A61K47/32 ,  A61K47/12 ,  A61K31/00

Abstract: The invention relates to a composition for transdermal delivery, particularly iontophoretic transdermal delivery, of at least one cationic active agent or a salt thereof. The composition includes at least one cationic active agent or a salt thereof, at least one polyamine or/and polyamine salt, water or an aqueous solvent mixture, and optionally one or more additives. The invention further relates to the use of such composition as a component of a transdermal patch or of an iontophoretic transdermal patch, as well as to the use of such composition in a method for transdermally and/or iontophoretically administering cationic active agents. The invention further includes methods for determining the in vitro skin permeation properties of an active-agent-containing iontophoretic composition.