公开(公告)号：US11213491B2

公开(公告)日：2022-01-04

申请号：US16094933

申请日：2017-04-20

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Markus Müller ,  Claudia Maria Hammes ,  Christoph Schmitz ,  Michael Linn ,  Mohammad Sameti ,  Peter Klaffenbach

IPC: A61K9/70 ,  A61K38/28 ,  A61K47/38 ,  A61P3/10 ,  A61P9/00 ,  A61K9/00 ,  A61K38/26

Abstract: The invention relates to film-like forms of administration for the transmucosal delivery of antidiabetic peptides via the oral mucosa and to processes for the production thereof. Antidiabetic peptides refers to peptides which are an active compound for the treatment of diabetes mellitus, and includes insulins, insulin analogs, incretins and incretin mimetics.

公开(公告)号：US10596126B2

公开(公告)日：2020-03-24

申请号：US16380069

申请日：2019-04-10

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Michael Horstmann ,  Mohammad Sameti ,  Tobias Jung

IPC: A61K9/70

Abstract: The present invention relates to a transdermal therapeutic system, preferably a transdermal patch, having an active ingredient-containing matrix formed substantially of a water-insoluble base material, such as rubber and synthetic polymers, into which is incorporated water-soluble and/or water-swellable inclusion bodies, e.g. inclusion bodies formed from polyvinyl alcohol or polyethylene glycol, that further include micronized or nanoscale active ingredient particles.

公开(公告)号：US11439807B2

公开(公告)日：2022-09-13

申请号：US16657147

申请日：2019-10-18

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Mohammad Sameti ,  Ronald Hackbarth ,  Klaus Schumann ,  Christoph Schmitz

IPC: A61N1/04 ,  A61K31/27 ,  A61K31/4468 ,  A61K31/485 ,  A61K31/55 ,  A61K38/22 ,  A61K38/27 ,  A61K38/28 ,  A61K38/36 ,  A61M37/00 ,  A61N1/30

Abstract: The invention relates to a transdermal therapeutic system (TTS) for delivering pharmaceutical active ingredients. The TTS includes a cover layer and at least one active-ingredient-containing carrier material. At least one retaining element is located between the active-ingredient-containing carrier material and the cover layer, with the retaining element fixing the active-ingredient-containing carrier material onto the cover layer. The invention further relates to a method for fastening an active-ingredient-containing carrier material to a cover layer of a TTS in the presence of hook-and-loop strip segments and the use of a hook-and-loop strip in transdermal or iontophoretic administration of pharmaceutical or therapeutic active ingredients to patients.

公开(公告)号：US10881607B2

公开(公告)日：2021-01-05

申请号：US16715972

申请日：2019-12-16

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Christoph Schmitz ,  Mohammad Sameti ,  Andreas Koch ,  Michael Horstmann

IPC: A61K9/00 ,  A61K9/70 ,  A61K47/32 ,  A61K47/12 ,  A61K31/00

Abstract: The invention relates to a composition for transdermal delivery, particularly iontophoretic transdermal delivery, of at least one cationic active agent or a salt thereof. The composition includes at least one cationic active agent or a salt thereof, at least one polyamine or/and polyamine salt, water or an aqueous solvent mixture, and optionally one or more additives. The invention further relates to the use of such composition as a component of a transdermal patch or of an iontophoretic transdermal patch, as well as to the use of such composition in a method for transdermally and/or iontophoretically administering cationic active agents. The invention further includes methods for determining the in vitro skin permeation properties of an active-agent-containing iontophoretic composition.