公开(公告)号：US20210287764A1

公开(公告)日：2021-09-16

申请号：US17303519

申请日：2021-06-01

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Hanshermann Franke ,  Patrick Mohr ,  René Eifler ,  Marius Bauer

IPC: G16C20/50 ,  G16C20/30 ,  G16C20/64

Abstract: A device and a method for determining a suitability of an active ingredient to be applied transdermally or transmucosally. In particular, a system that includes: at least one input device for inputting at least one designation of an active ingredient; a database for storing a plurality of data at least relating to the active ingredient; a computing unit for assessing a suitability of the active ingredient to be applied transdermally and/or transmucosally while taking into consideration data entered via the input device and/or data stored in the database; and an output device for displaying the assessed suitability.

公开(公告)号：US11304912B2

公开(公告)日：2022-04-19

申请号：US16765800

申请日：2018-11-21

Applicant: LTS LOHMANN THERAPIE-SYSTEME AG

Inventor： Michael Linn ,  Markus Müller ,  Marius Bauer

IPC: A61K9/70 ,  A61K31/122 ,  A61K31/24 ,  A61K31/506 ,  A61K31/381 ,  A61K31/4545 ,  A61K31/135 ,  A61K31/663 ,  A61K31/4468

Abstract: The present application relates to a transdermal therapeutic system comprising a backing layer impermeable to active substances and a polymer matrix on one side of the backing layer impermeable to active substances, wherein the polymer matrix comprises at least one pharmaceutically active substance, at least one inherently non-self-adhesive polymer and at least one plasticizer, said polymer matrix being free of adhesive polymers. The invention further relates to a method of producing the transdermal therapeutic system and to the use thereof as a drug.

公开(公告)号：US20170046504A1

公开(公告)日：2017-02-16

申请号：US15118757

申请日：2015-02-24

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Hanshermann Franke ,  Patrick Mohr ,  René Eifler ,  Marius Bauer

IPC: G06F19/00

CPC classification number: G16C20/50 ,  G16B35/00 ,  G16C20/30 ,  G16C20/60

Abstract: A device and a method for determining a suitability of an active ingredient to be applied transdermally or transmucosally. In particular, a system that includes: at least one input device for inputting at least one designation of an active ingredient; a database for storing a plurality of data at least relating to the active ingredient; a computing unit for assessing a suitability of the active ingredient to be applied transdermally and/or transmucosally while taking into consideration data entered via the input device and/or data stored in the database; and an output device for displaying the assessed suitability.

Abstract translation: 本发明的目的是提供一种用于确定经皮或经粘膜应用的活性成分的适用性的装置和方法。 这通过包括以下的系统来实现： - 用于输入活性成分的至少一个指定的至少一个输入装置（101） - 数据库（110），用于存储至少与活性成分有关的多个数据; - 计算单元（102），用于评估通过经皮和/或经粘膜施用的活性成分的适用性，同时考虑经由输入装置（101）输入的数据和/或存储在数据库（110）中的数据; 以及 - 用于显示所评估的适用性的输出装置（103）。

公开(公告)号：US11547677B2

公开(公告)日：2023-01-10

申请号：US16490684

申请日：2018-02-28

Applicant: LTS LOHMANN THERAPIE-SYSTEME AG ,  SANTHERA PHARMACEUTICALS (SCHWEIZ) AG

Inventor： Michael Linn ,  Markus Muller ,  Marius Bauer

IPC: A61K31/22 ,  A61K9/113 ,  A61K47/38 ,  A61K47/32 ,  A61K47/12 ,  A61K47/14 ,  A61K47/22 ,  A61K47/10 ,  A61K47/34 ,  A61K9/00 ,  A61K31/122

Abstract: The invention relates to a transmucosal delivery system for idebenone, comprising an external phase, which contains at least one hydrophilic polymer, and an inner hydrophobic phase, which contains idebenone and at least one hydrophobic substance, wherein the inner hydrophobic phase is emulsified in the form of droplets in the external phase. The invention is characterized in that the inner hydrophobic phase is stabilized by at least one emulsifier in the external phase. The invention also relates to a method for producing the same and its use as a medicament.