公开(公告)号：US20170046504A1

公开(公告)日：2017-02-16

申请号：US15118757

申请日：2015-02-24

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Hanshermann Franke ,  Patrick Mohr ,  René Eifler ,  Marius Bauer

IPC: G06F19/00

CPC classification number: G16C20/50 ,  G16B35/00 ,  G16C20/30 ,  G16C20/60

Abstract: A device and a method for determining a suitability of an active ingredient to be applied transdermally or transmucosally. In particular, a system that includes: at least one input device for inputting at least one designation of an active ingredient; a database for storing a plurality of data at least relating to the active ingredient; a computing unit for assessing a suitability of the active ingredient to be applied transdermally and/or transmucosally while taking into consideration data entered via the input device and/or data stored in the database; and an output device for displaying the assessed suitability.

Abstract translation: 本发明的目的是提供一种用于确定经皮或经粘膜应用的活性成分的适用性的装置和方法。 这通过包括以下的系统来实现： - 用于输入活性成分的至少一个指定的至少一个输入装置（101） - 数据库（110），用于存储至少与活性成分有关的多个数据; - 计算单元（102），用于评估通过经皮和/或经粘膜施用的活性成分的适用性，同时考虑经由输入装置（101）输入的数据和/或存储在数据库（110）中的数据; 以及 - 用于显示所评估的适用性的输出装置（103）。

公开(公告)号：US10980753B2

公开(公告)日：2021-04-20

申请号：US16445582

申请日：2019-06-19

Applicant: LTS LOHMANN Therapie-Systeme AG

Inventor： Patrick Mohr ,  René Rietscher ,  René Eifler ,  Olga Bourquain

IPC: A61K9/70 ,  A61P25/18 ,  A61K31/407 ,  A61P9/12 ,  A61K9/00

Abstract: The present invention relates to transdermal therapeutic systems (TTS) for the transdermal administration of asenapine comprising a self-adhesive layer structure containing a therapeutically effective amount of asenapine, such asenapine TTS for use in a method of treatment, processes of manufacture of such TTS as well as asenapine and transdermal therapeutic systems containing asenapine for use in a method of treatment and to a method of treating a human patient by transdermal administration of asenapine.

公开(公告)号：US10898449B2

公开(公告)日：2021-01-26

申请号：US16788128

申请日：2020-02-11

Applicant: LTS LOHMANN Therapie-Systeme AG

Inventor： Patrick Mohr ,  René Rietscher ,  René Eifler ,  Olga Bourquain

IPC: A61K9/70 ,  A61P25/28 ,  A61P25/18 ,  A61P25/24 ,  A61P25/00 ,  A61P25/16 ,  A61K31/407 ,  A61P9/12 ,  A61K9/00

Abstract: The present invention relates to transdermal therapeutic systems (TTS) for the transdermal administration of asenapine comprising a self-adhesive layer structure containing a therapeutically effective amount of asenapine, such asenapine TTS for use in a method of treatment, processes of manufacture of such TTS as well as asenapine and transdermal therapeutic systems containing asenapine for use in a method of treatment and to a method of treating a human patient by transdermal administration of asenapine.

公开(公告)号：US20140234395A1

公开(公告)日：2014-08-21

申请号：US14346527

申请日：2012-09-25

Applicant: LTS LOHMANN THERAPIE-SYSTEME AG

Inventor： Walter Müller ,  Patrick Mohr

IPC: A61K9/70 ,  A61K31/167 ,  A61K31/245 ,  A61K31/196

CPC classification number: A61K9/7053 ,  A61K9/0014 ,  A61K9/7023 ,  A61K9/7061 ,  A61K9/7084 ,  A61K31/167 ,  A61K31/196 ,  A61K31/245 ,  A61L15/225 ,  A61L15/42 ,  A61L15/44 ,  A61L15/48 ,  A61L15/58 ,  A61L2300/402 ,  A61L2300/41 ,  C08L53/02 ,  C08L33/00 ,  C08L83/04

Abstract: Transdermal or topical plasters containing active ingredient are provided that include a non-occlusive back layer, a matrix formed from of one or more polymer layers having at least one pharmaceutical active ingredient in one or more of the layers, in which the structure-forming base polymers of the layer(s) are non-occlusive or only slightly occlusive and a second polymer that has a low water-vapor permeability and that is immiscible or only very slightly miscible with the base polymer is dispersed in at least one of the polymer layers.

Abstract translation: 提供含有活性成分的透皮或局部膏药，其包括非闭塞性背层，由一层或多层在一层或多层中具有至少一种药物活性成分的聚合物层形成的基质，其中结构形成基质 层的聚合物是非闭塞的或只是轻微闭塞的，并且具有低水蒸气渗透性并且与基础聚合物不混溶或仅与其非常轻微混溶的第二聚合物分散在至少一个聚合物层 。

公开(公告)号：US11648213B2

公开(公告)日：2023-05-16

申请号：US17250163

申请日：2019-06-19

Applicant: LTS LOHMANN THERAPIE-SYSTEME AG

Inventor： Patrick Mohr ,  René Rietscher ,  René Eifler ,  Olga Bourquain

IPC: A61K9/70 ,  A61K31/407 ,  A61K47/02 ,  A61K47/14 ,  A61K47/22 ,  A61K47/32

CPC classification number: A61K9/7061 ,  A61K31/407 ,  A61K47/02 ,  A61K47/14 ,  A61K47/22 ,  A61K47/32

Abstract: The present invention relates to transdermal therapeutic systems (TTS) for the transdermal administration of asenapine comprising a self-adhesive layer structure containing a therapeutically effective amount of asenapine, such asenapine TTS for use in a method of treatment, processes of manufacture of such TTS as well as asenapine and transdermal therapeutic systems containing asenapine for use in a method of treatment and to a method of treating a human patient by transdermal administration of asenapine.

公开(公告)号：US11337932B2

公开(公告)日：2022-05-24

申请号：US16470322

申请日：2017-12-19

Applicant: LTS LOHMANN Therapie-Systeme AG

Inventor： Patrick Mohr ,  René Rietscher ,  René Eifler ,  Olga Bourquain

IPC: A61K9/70 ,  A61K31/407

Abstract: The present invention relates to a transdermal therapeutic system (TTS) for the transdermal administration of asenapine comprising a self-adhesive layer structure comprising a therapeutically effective amount of asenapine, said self-adhesive layer structure comprising: A) a backing layer; B) an asenapine-containing layer comprising: 1. asenapine in the form of the free base; and 2. a polymer selected from the group consisting of polysiloxanes and polyisobutylenes in an amount of more than 50% by weight based on the total weight of the asenapine-containing layer; and C) optionally an additional skin contact layer.

公开(公告)号：US20210287764A1

公开(公告)日：2021-09-16

申请号：US17303519

申请日：2021-06-01

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Hanshermann Franke ,  Patrick Mohr ,  René Eifler ,  Marius Bauer

IPC: G16C20/50 ,  G16C20/30 ,  G16C20/64

Abstract: A device and a method for determining a suitability of an active ingredient to be applied transdermally or transmucosally. In particular, a system that includes: at least one input device for inputting at least one designation of an active ingredient; a database for storing a plurality of data at least relating to the active ingredient; a computing unit for assessing a suitability of the active ingredient to be applied transdermally and/or transmucosally while taking into consideration data entered via the input device and/or data stored in the database; and an output device for displaying the assessed suitability.

公开(公告)号：US09180103B2

公开(公告)日：2015-11-10

申请号：US14346527

申请日：2012-09-25

Applicant: LTS LOHMANN THERAPIE-SYSTEME AG

Inventor： Walter Müller ,  Patrick Mohr

IPC: A61F13/02 ,  A61K9/70 ,  A61K9/00 ,  A61L15/22 ,  A61L15/44 ,  A61L15/58 ,  A61L15/42 ,  A61L15/48 ,  A61K31/167 ,  A61K31/196 ,  A61K31/245

CPC classification number: A61K9/7053 ,  A61K9/0014 ,  A61K9/7023 ,  A61K9/7061 ,  A61K9/7084 ,  A61K31/167 ,  A61K31/196 ,  A61K31/245 ,  A61L15/225 ,  A61L15/42 ,  A61L15/44 ,  A61L15/48 ,  A61L15/58 ,  A61L2300/402 ,  A61L2300/41 ,  C08L53/02 ,  C08L33/00 ,  C08L83/04

Abstract: Transdermal or topical plasters containing active ingredient are provided that include a non-occlusive back layer, a matrix formed from of one or more polymer layers having at least one pharmaceutical active ingredient in one or more of the layers, in which the structure-forming base polymers of the layer(s) are non-occlusive or only slightly occlusive and a second polymer that has a low water-vapor permeability and that is immiscible or only very slightly miscible with the base polymer is dispersed in at least one of the polymer layers.

Abstract translation: 提供含有活性成分的透皮或局部膏药，其包括非闭塞性背层，由一层或多层在一层或多层中具有至少一种药物活性成分的聚合物层形成的基质，其中结构形成基质 层的聚合物是非闭塞的或只是轻微闭塞的，并且具有低水蒸气渗透性并且与基础聚合物不混溶或仅与其非常轻微混溶的第二聚合物分散在至少一个聚合物层 。

公开(公告)号：US12138353B2

公开(公告)日：2024-11-12

申请号：US17195267

申请日：2021-03-08

Applicant: LTS LOHMANN Therapie-Systeme AG

Inventor： Patrick Mohr ,  René Rietscher ,  René Eifler ,  Olga Bourquain

IPC: A61K9/70 ,  A61K31/407 ,  A61P25/18 ,  A61K9/00 ,  A61P9/12

Abstract: The present invention relates to transdermal therapeutic systems (TTS) for the transdermal administration of asenapine comprising a self-adhesive layer structure containing a therapeutically effective amount of asenapine, such asenapine TTS for use in a method of treatment, processes of manufacture of such TTS as well as asenapine and transdermal therapeutic systems containing asenapine for use in a method of treatment and to a method of treating a human patient by transdermal administration of asenapine.

公开(公告)号：US11291745B2

公开(公告)日：2022-04-05

申请号：US16239862

申请日：2019-01-04

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Michael Horstmann ,  Christian Hausen ,  Patrick Mohr ,  Karin Ludwig ,  Tobias Kleudgen

IPC: A61L15/44 ,  A61L15/24 ,  A61L15/58

Abstract: Adhesive bandages are provided with a water-vapor permeable back layer and an adhesive layer, in which the adhesive layer includes 10 weight percent of a disperse internal phase of hydrophilic particles that are water-swellable in an outer phase that includes at least 10 weight percent of a styrene block copolymer and at least 20 weight percent of an ester resin of colophony, and that can further contain at least one anti-virus substance.