公开(公告)号：US09399638B2

公开(公告)日：2016-07-26

申请号：US14398154

申请日：2013-05-01

Applicant: LUPIN LIMITED

Inventor： Nageswara Rao Irlapati ,  Zubair Abdul Wajid Shaikh ,  Vijay Pandurang Karche ,  Gokul Keruji Deshmukh ,  Neelima Sinha ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC: C07D413/04 ,  C07D417/14 ,  C07D413/14

CPC classification number: C07D413/14 ,  C07D413/04 ,  C07D417/14

Abstract: The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium release-activated calcium (CRAC) channel. The invention also describes the compounds of Formula (I) and pharmaceutical compositions containing such compounds thereof for treating, managing, and/or lessening the severity of diseases, disorders, syndromes or conditions associated with the modulation of calcium release-activated calcium (CRAC) channel.

Abstract translation: 本发明涉及调节钙释放活化的钙（CRAC）通道的活性的式（I）化合物及其药学上可接受的盐。 本发明还描述了式（I）的化合物和含有其化合物的药物组合物，用于治疗，治疗和/或降低与调节钙释放激活的钙（CRAC）相关的疾病，病症，综合征或病症的严重性， 渠道。

公开(公告)号：US10292981B2

公开(公告)日：2019-05-21

申请号：US15642899

申请日：2017-07-06

Applicant: LUPIN LIMITED

Inventor： Nageswara Rao Irlapati ,  Gokul Keruji Deshmukh ,  Vijay Pandurang Karche ,  Santosh Madhukar Jachak ,  Neelima Sinha ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC: C07D271/113 ,  A61K31/4245 ,  A61P11/06 ,  A61K31/497 ,  C07D261/12 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/496

Abstract: The present invention relates to compounds of Formula (I), along with processes for their preparation that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of CRAC. The invention further relates to methods of treating, preventing managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of CRAC of Formula (I).

公开(公告)号：US09737534B2

公开(公告)日：2017-08-22

申请号：US14840118

申请日：2015-08-31

Applicant: LUPIN LIMITED

Inventor： Nageswara Rao Irlapati ,  Gokul Keruji Deshmukh ,  Vijay Pandurang Karche ,  Santosh Madhukar Jachak ,  Neelima Sinha ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC: C07D271/113 ,  A61K31/4245 ,  A61P19/02 ,  A61K31/497 ,  C07D261/12 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/496

CPC classification number: A61K31/497 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/496 ,  C07D261/12 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to compounds of Formula (I), along with processes for their preparation that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of CRAC. The invention further relates to methods of treating, preventing managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of CRAC of Formula (I).

公开(公告)号：US20150111900A1

公开(公告)日：2015-04-23

申请号：US14398154

申请日：2013-05-01

Applicant: LUPIN LIMITED

Inventor： Nageswara Rao Irlapati ,  Zubair Abdul Wajid Shaikh ,  Vijay Pandurang Karche ,  Gokul Keruji Deshmukh ,  Neelima Sinha ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC: C07D417/14 ,  C07D413/14 ,  C07D413/04

CPC classification number: C07D413/14 ,  C07D413/04 ,  C07D417/14

Abstract: The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium release-activated calcium (CRAC) channel. The invention also describes the compounds of Formula (I) and pharmaceutical compositions containing such compounds thereof for treating, managing, and/or lessening the severity of diseases, disorders, syndromes or conditions associated with the modulation of calcium release-activated calcium (CRAC) channel.

Abstract translation: 本发明涉及调节钙释放活化的钙（CRAC）通道的活性的式（I）化合物及其药学上可接受的盐。 本发明还描述了式（I）化合物和含有其化合物的药物组合物，用于治疗，控制和/或降低与调节钙释放激活的钙（CRAC）相关的疾病，病症，综合征或病症的严重性， 渠道。

公开(公告)号：US09790231B2

公开(公告)日：2017-10-17

申请号：US14900425

申请日：2014-06-23

Applicant: LUPIN LIMITED

Inventor： Nageswara Rao Irlapati ,  Kiran Chandrashekhar Kulkarni ,  Vijay Pandurang Karche ,  Gokul Keruji Deshmukh ,  Neelima Sinha ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC: A61K31/352 ,  C07D311/04 ,  C07D311/96 ,  C07D405/04 ,  C07D405/12 ,  C07D491/107 ,  C07D311/22 ,  C07D311/58 ,  C07D491/10 ,  C07D493/10

CPC classification number: C07D491/107 ,  C07D311/04 ,  C07D311/22 ,  C07D311/58 ,  C07D311/96 ,  C07D405/04 ,  C07D405/12 ,  C07D491/10 ,  C07D493/10

Abstract: The invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine for the treatment of diseases, disorders associated with the modulation of calcium release-activated calcium (CRAC) channel. The invention also relates to pharmaceutical compositions containing such compounds in treating diseases disorders associated with calcium release-activated calcium (CRAC) channel modulators.