MAGE-C2 antigenic peptides and uses thereof
    4.
    发明申请
    MAGE-C2 antigenic peptides and uses thereof 有权
    MAGE-C2抗原肽及其用途

    公开(公告)号:US20080311652A1

    公开(公告)日:2008-12-18

    申请号:US12011726

    申请日:2008-01-29

    IPC分类号: C12N5/00 C07H21/04 C12N15/63

    摘要: This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, β2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.

    摘要翻译: 本发明涉及衍生自MAGE-C2的分离的肽,编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽,包含核酸分子的表达载体,用核酸分子转化或转染的宿主细胞 表达载体和包含肽,HLA分子,β2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽,核酸分子,表达载体,四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。

    MAGE-C2 antigenic peptides and uses thereof
    5.
    发明授权
    MAGE-C2 antigenic peptides and uses thereof 有权
    MAGE-C2抗原肽及其用途

    公开(公告)号:US07785881B2

    公开(公告)日:2010-08-31

    申请号:US12011726

    申请日:2008-01-29

    IPC分类号: C12N15/86

    摘要: This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, β2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.

    摘要翻译: 本发明涉及衍生自MAGE-C2的分离的肽,编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽,包含核酸分子的表达载体,用核酸分子转化或转染的宿主细胞 表达载体以及包含肽,HLA分子,2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽,核酸分子,表达载体,四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。

    Mage C2 antigenic peptides and uses thereof
    6.
    发明授权
    Mage C2 antigenic peptides and uses thereof 有权
    法师C2抗原肽及其用途

    公开(公告)号:US07348007B2

    公开(公告)日:2008-03-25

    申请号:US11044051

    申请日:2005-01-28

    IPC分类号: A61K39/00

    摘要: This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, β2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.

    摘要翻译: 本发明涉及衍生自MAGE-C2的分离的肽,编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽,包含核酸分子的表达载体,用核酸分子转化或转染的宿主细胞 表达载体和包含肽,HLA分子,β2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽,核酸分子,表达载体,四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。

    Isolated protein molecules which are members of the MAGE-B family
    8.
    发明授权
    Isolated protein molecules which are members of the MAGE-B family 有权
    分离的蛋白质分子是MAGE-B家族的成员

    公开(公告)号:US06392016B1

    公开(公告)日:2002-05-21

    申请号:US09443077

    申请日:1999-11-18

    IPC分类号: C07K100

    摘要: The invention relates to members of the MAGE-B family of nucleic acid molecules. These molecules differ from the previously described MAGE nucleic acid molecules in that members of the MAGE-Xp family do not hybridize to the previously identified MAGE sequences. Further, the members of the MAGE-B family are found on the Xp arm of the X chromosome rather than on the Xq chromosome, as was the case with the previously identified MAGE genes.

    摘要翻译: 本发明涉及MAGE-B家族核酸分子的成员。 这些分子与先前描述的MAGE核酸分子不同,因为MAGE-Xp家族的成员不与先前鉴定的MAGE序列杂交。 此外,MAGE-B家族的成员位于X染色体的Xp臂上而不是Xq染色体上,如以前鉴定的MAGE基因的情况。