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1.发明授权Methods for diagnosing multiple myeloma by determining rejection antigen precursors 失效通过确定排斥抗原前体来诊断多发性骨髓瘤的方法公开(公告)号：US06387630B1
公开(公告)日：2002-05-14
申请号：US09705160
申请日：2000-11-02
IPC分类号： C12Q168
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： Methods for diagnosing multiple myeloma are disclosed. These methods are based upon the observation that tumor rejection antigen precursors are expressed in multiple myeloma. By assaying bone marrow samples, one can diagnose multiple myeloma, and also monitor the disease's progress. Therapeutic approaches to multiple myeloma are also disclosed.
摘要翻译： 公开了诊断多发性骨髓瘤的方法。 这些方法基于观察到肿瘤排斥抗原前体在多发性骨髓瘤中表达。 通过分析骨髓样本，可以诊断多发性骨髓瘤，并监测疾病的进展。 还公开了多发性骨髓瘤的治疗方法。
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2.发明授权Method for determining multiple myeloma by assaying for expression of mage genes 失效通过测定法师基因表达来确定多发性骨髓瘤的方法
公开(公告)号：US5985571A
公开(公告)日：1999-11-16
申请号：US18422
申请日：1998-02-04
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Methods for diagnosing multiple myeloma are disclosed. These methods are based upon the observation that tumor rejection antigen precursors are expressed in multiple myeloma. By assaying bone marrow samples, one can diagnose multiple myeloma, and also monitor the disease's progress. Therapeutic approaches of multiple myeloma are also disclosed.
摘要翻译： 公开了诊断多发性骨髓瘤的方法。 这些方法基于观察到肿瘤排斥抗原前体在多发性骨髓瘤中表达。 通过分析骨髓样本，可以诊断多发性骨髓瘤，并监测疾病的进展。 还公开了多发性骨髓瘤的治疗方法。
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3.发明授权Method for diagnosing multiple myeloma by determining tumor rejection antigen precursors 失效通过确定肿瘤排斥抗原前体来诊断多发性骨髓瘤的方法公开(公告)号：US06210886B1
公开(公告)日：2001-04-03
申请号：US09183931
申请日：1998-10-30
IPC分类号： C12Q168
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： Methods for diagnosing multiple myeloma are disclosed. These methods are based upon the observation that tumor rejection antigen precursors are expressed in multiple myeloma. By assaying bone marrow samples, one can diagnose multiple myeloma, and also monitor the disease's progress. Therapeutic approaches to multiple myeloma are also disclosed.
摘要翻译： 公开了诊断多发性骨髓瘤的方法。 这些方法基于观察到肿瘤排斥抗原前体在多发性骨髓瘤中表达。 通过分析骨髓样本，可以诊断多发性骨髓瘤，并监测疾病的进展。 还公开了多发性骨髓瘤的治疗方法。
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公开(公告)号：US6165725A
公开(公告)日：2000-12-26
申请号：US351351
申请日：1999-07-12
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Methods for diagnosing multiple myeloma are disclosed. These methods are based upon the observation that tumor rejection antigen precursors are expressed in multiple myeloma. By assaying bone marrow samples, one can diagnose multiple myeloma, and also monitor the disease's progress. Therapeutic approaches of multiple myeloma are also disclosed.
摘要翻译： 公开了诊断多发性骨髓瘤的方法。 这些方法基于观察到肿瘤排斥抗原前体在多发性骨髓瘤中表达。 通过分析骨髓样本，可以诊断多发性骨髓瘤，并监测疾病的进展。 还公开了多发性骨髓瘤的治疗方法。
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公开(公告)号：US20090209034A1
公开(公告)日：2009-08-20
申请号：US12364746
申请日：2009-02-03
CPC分类号： C07K14/4748 , A61K38/00
摘要： Polypeptides comprising an unbroken sequence of amino acids from SEQ. ID. NO. 1 or 2, with an ability to complex with a major histocompatibility complex molecule type HLA-A2, and preferably HLA-A2.1.
摘要翻译： 包含SEQ ID NO：1的氨基酸序列的多肽。 ID。 没有。 1或2，具有与主要组织相容性复合分子型HLA-A2，优选HLA-A2.1复合的能力。
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公开(公告)号：US20080311652A1
公开(公告)日：2008-12-18
申请号：US12011726
申请日：2008-01-29
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/57
摘要： This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, β2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.
摘要翻译： 本发明涉及衍生自MAGE-C2的分离的肽，编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽，包含核酸分子的表达载体，用核酸分子转化或转染的宿主细胞 表达载体和包含肽，HLA分子，β2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽，核酸分子，表达载体，四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。
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公开(公告)号：US07785881B2
公开(公告)日：2010-08-31
申请号：US12011726
申请日：2008-01-29
IPC分类号： C12N15/86
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/57
摘要： This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, β2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.
摘要翻译： 本发明涉及衍生自MAGE-C2的分离的肽，编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽，包含核酸分子的表达载体，用核酸分子转化或转染的宿主细胞 表达载体以及包含肽，HLA分子，2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽，核酸分子，表达载体，四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。
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公开(公告)号：US06392016B1
公开(公告)日：2002-05-21
申请号：US09443077
申请日：1999-11-18
IPC分类号： C07K100
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/158
摘要： The invention relates to members of the MAGE-B family of nucleic acid molecules. These molecules differ from the previously described MAGE nucleic acid molecules in that members of the MAGE-Xp family do not hybridize to the previously identified MAGE sequences. Further, the members of the MAGE-B family are found on the Xp arm of the X chromosome rather than on the Xq chromosome, as was the case with the previously identified MAGE genes.
摘要翻译： 本发明涉及MAGE-B家族核酸分子的成员。 这些分子与先前描述的MAGE核酸分子不同，因为MAGE-Xp家族的成员不与先前鉴定的MAGE序列杂交。 此外，MAGE-B家族的成员位于X染色体的Xp臂上而不是Xq染色体上，如以前鉴定的MAGE基因的情况。
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公开(公告)号：US06897288B1
公开(公告)日：2005-05-24
申请号：US09692401
申请日：2000-10-19
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K2039/5154
摘要： The invention provides antigenic peptides derived from MAGE-A12 polypeptides and presented by HLA molecules. Methods for diagnosis and treatment which involve the polypeptides also are provided.
摘要翻译： 本发明提供了衍生自MAGE-A12多肽并由HLA分子呈递的抗原肽。 还提供了涉及多肽的诊断和治疗方法。
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10.发明授权Method for determining lung adenocarcinomas by assaying for one or more of MAGE-1, MAGE-2 and MAGE-3 失效通过测定MAGE-1，MAGE-2和MAGE-3中的一种或多种来测定肺腺癌的方法
公开(公告)号：US5763165A
公开(公告)日：1998-06-09
申请号：US209172
申请日：1994-03-10
申请人： Thierry Boon-Falleur , Patrick Weynants , Bernard Lethe , Francis Brasseur , Marie Marchand , Charles DeSmet , Christophe Lurquin , Pierre van der Bruggen , Etienne DePlaen
发明人： Thierry Boon-Falleur , Patrick Weynants , Bernard Lethe , Francis Brasseur , Marie Marchand , Charles DeSmet , Christophe Lurquin , Pierre van der Bruggen , Etienne DePlaen
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/158
摘要： A method for determining lung adenocarcinomas is described. The method involves assaying for expression of a gene coding for at least one of tumor rejection antigen precursors MAGE-1, 2 and 3, or their expression product.
摘要翻译： 描述了确定肺腺癌的方法。 该方法包括测定编码肿瘤排斥抗原前体MAGE-1,2和3中的至少一种或其表达产物的基因的表达。
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