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公开(公告)号：US06392016B1
公开(公告)日：2002-05-21
申请号：US09443077
申请日：1999-11-18
IPC分类号： C07K100
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/158
摘要： The invention relates to members of the MAGE-B family of nucleic acid molecules. These molecules differ from the previously described MAGE nucleic acid molecules in that members of the MAGE-Xp family do not hybridize to the previously identified MAGE sequences. Further, the members of the MAGE-B family are found on the Xp arm of the X chromosome rather than on the Xq chromosome, as was the case with the previously identified MAGE genes.
摘要翻译： 本发明涉及MAGE-B家族核酸分子的成员。 这些分子与先前描述的MAGE核酸分子不同，因为MAGE-Xp家族的成员不与先前鉴定的MAGE序列杂交。 此外，MAGE-B家族的成员位于X染色体的Xp臂上而不是Xq染色体上，如以前鉴定的MAGE基因的情况。
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2.发明授权Method for determining lung adenocarcinomas by assaying for one or more of MAGE-1, MAGE-2 and MAGE-3 失效通过测定MAGE-1，MAGE-2和MAGE-3中的一种或多种来测定肺腺癌的方法
公开(公告)号：US5763165A
公开(公告)日：1998-06-09
申请号：US209172
申请日：1994-03-10
申请人： Thierry Boon-Falleur , Patrick Weynants , Bernard Lethe , Francis Brasseur , Marie Marchand , Charles DeSmet , Christophe Lurquin , Pierre van der Bruggen , Etienne DePlaen
发明人： Thierry Boon-Falleur , Patrick Weynants , Bernard Lethe , Francis Brasseur , Marie Marchand , Charles DeSmet , Christophe Lurquin , Pierre van der Bruggen , Etienne DePlaen
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/158
摘要： A method for determining lung adenocarcinomas is described. The method involves assaying for expression of a gene coding for at least one of tumor rejection antigen precursors MAGE-1, 2 and 3, or their expression product.
摘要翻译： 描述了确定肺腺癌的方法。 该方法包括测定编码肿瘤排斥抗原前体MAGE-1,2和3中的至少一种或其表达产物的基因的表达。
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3.发明授权Isolated nucleic acid molecules which are members of the MAGE-B family and uses thereof 失效分离的核酸分子，其是MAGE-B家族的成员并且使用它们
公开(公告)号：US6017705A
公开(公告)日：2000-01-25
申请号：US846111
申请日：1997-04-25
IPC分类号： C12N15/09 , A61K39/00 , A61K48/00 , A61P35/00 , C07K14/47 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/158
摘要： The invention relates to members of the MAGE-B family of nucleic acid molecules. These molecules differ from the previously described MAGE nucleic acid molecules in that members of the MAGE-Xp family do not hybridize to the previously identified MAGE sequences. Further, the members of the MAGE-B family are found on the Xp arm of the X chromosome rather than on the Xq chromosome, as was the case with the previously identified MASGE genes.
摘要翻译： 本发明涉及MAGE-B家族核酸分子的成员。 这些分子与先前描述的MAGE核酸分子不同，因为MAGE-Xp家族的成员不与先前鉴定的MAGE序列杂交。 此外，MAGE-B家族的成员在X染色体的Xp臂上发现，而不是在Xq染色体上，如先前鉴定的MASGE基因的情况。
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4.发明授权Method for determining lung adenocarcinomas by assaying for one or more of MAGE-1, MAGE-2 and MAGE-3 gene products 失效通过测定MAGE-1，MAGE-2和MAGE-3基因产物中的一种或多种来测定肺腺癌的方法
公开(公告)号：US5763155A
公开(公告)日：1998-06-09
申请号：US644569
申请日：1996-05-10
申请人： Thierry Boon-Falleur , P. Weynants , Bernard Lethe , Francis Brasseur , M. Marchand , Charles DeSmet , Christophe Lurquin , Pierre Van Der Bruggen , Etienne DePlaen
发明人： Thierry Boon-Falleur , P. Weynants , Bernard Lethe , Francis Brasseur , M. Marchand , Charles DeSmet , Christophe Lurquin , Pierre Van Der Bruggen , Etienne DePlaen
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/158
摘要： A method for determining lung adenocarcinomas is described. The method involves assaying for expression of a gene coding for at least one of tumor rejection antigen precursors MAGE-1, 2 and 3, or their expression product.
摘要翻译： 描述了确定肺腺癌的方法。 该方法包括测定编码肿瘤排斥抗原前体MAGE-1,2和3中的至少一种或其表达产物的基因的表达。
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5.发明授权Method of screening for cancer by detecting messenger RNA for a MAGE-XP gene 失效通过检测MAGE-XP基因的信使RNA来筛选癌症的方法
公开(公告)号：US5759783A
公开(公告)日：1998-06-02
申请号：US658578
申请日：1996-06-05
IPC分类号： C12N15/09 , A61K39/00 , A61K48/00 , A61P35/00 , C07K14/47 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/158
摘要： The invention involves assaying for possible presence of certain cancers, by screening a sample for a member of the MAGE-Xp family of genes. These cancers include testicular seminoma, non-small call lung carcinoma, melanoma, breast cancer, sarcoma, and leukemia.
摘要翻译： 本发明涉及通过筛选MAGE-Xp家族成员的样品来测定某些癌症的可能存在。 这些癌症包括睾丸精原细胞瘤，非小细胞肺癌，黑素瘤，乳腺癌，肉瘤和白血病。
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公开(公告)号：US06407063B1
公开(公告)日：2002-06-18
申请号：US09165863
申请日：1998-10-02
申请人： Rosalie Luiten , Marie-Therese Duffour , Nathalie Demotte , Pierre van der Bruggan , Guy Cornelius , Vincent Stroobant , Christophe Lurquin , Thierry Boon-Falleur
发明人： Rosalie Luiten , Marie-Therese Duffour , Nathalie Demotte , Pierre van der Bruggan , Guy Cornelius , Vincent Stroobant , Christophe Lurquin , Thierry Boon-Falleur
IPC分类号： A61K3808
CPC分类号： C07K14/4748
摘要： The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for MAGE-1 and MAGE-4, respectively. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to the MAGE-1 and MAGE-4 antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.
摘要翻译： 本发明涉及细胞毒性T淋巴细胞（CTL）克隆的分离。 特别地，本发明涉及分别对MAGE-1和MAGE-4特异的分离的CTL克隆。 本发明的CTL克隆已经通过连续的步骤来刺激和测试淋巴细胞来分离，所述抗原呈递细胞提供来自不同表达系统的抗原，例如来自重组耶尔森氏菌，重组沙门氏菌或重组病毒。 本发明还涉及由分离的CTL克隆识别的MAGE-1和MAGE-4抗原肽以及肽/ HLA复合物。
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7.发明授权Isolated nucleic acid molecules which are members of the MAGE-Xp family and uses thereof 失效作为MAGE-Xp家族成员的分离的核酸分子及其用途
公开(公告)号：US5587289A
公开(公告)日：1996-12-24
申请号：US403388
申请日：1995-03-14
IPC分类号： C12N15/09 , A61K39/00 , A61K48/00 , A61P35/00 , C07K14/47 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/68 , C07H21/02 , C07H21/04 , C12N15/70
CPC分类号： C07K14/4748 , C12Q1/6886
摘要： The invention relates to members of the MAGE-Xp family of nucleic acid molecules. These molecules differ from the previously described MAGE nucleic acid molecules in that members of the MAGE-Xp family do not hybridize to the previously identified MAGE sequences. Further, the members of the MAGE-Xp family are found on the Xp arm of the X chromosome rather than on the Xq chromosome, as was the case with the previously identified MAGE genes.
摘要翻译： 本发明涉及MAGE-Xp核酸分子家族的成员。 这些分子与先前描述的MAGE核酸分子不同，因为MAGE-Xp家族的成员不与先前鉴定的MAGE序列杂交。 此外，MAGE-Xp家族的成员位于X染色体的Xp臂上而不是Xq染色体上，如以前鉴定的MAGE基因的情况。
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8.发明授权
公开(公告)号：US5462871A
公开(公告)日：1995-10-31
申请号：US073103
申请日：1993-06-07
申请人： Thierry Boon-Falleur , Pierre van der Bruggen , Etienne De Plaen , Christophe Lurquin , Catia Traversari , Beatrice Gaugler , Benoit Van den Eynde
发明人： Thierry Boon-Falleur , Pierre van der Bruggen , Etienne De Plaen , Christophe Lurquin , Catia Traversari , Beatrice Gaugler , Benoit Van den Eynde
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/395 , A61P37/00 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/705 , C07K16/28 , C07K16/30 , C12N5/10 , C12N5/12 , C12N5/18 , C12N15/09 , C12P21/02 , C12P21/08 , G01N33/574 , G01N33/577 , C12N15/12 , C12N1/21
CPC分类号： C07K16/30 , C07K14/4748 , A61K38/00 , A61K39/00
摘要： The invention relates to isolated nucleic acid molecules which encode nonapeptides derived from MAGE tumor rejection antigen precursors. The nonapeptides form complexes with human leukocyte antigens presented on the surfaces of cells, and lead to lysis of these cells by cytolytic T lymphocytes. Thus, they are useful in diagnostic methods. Also a part of the invention are vectors which are designed to encode the nonapeptides as well as cell lines which have been transformed or transfected with the isolated nucleic acid molecules of the invention, or vectors including these molecules.
摘要翻译： 本发明涉及编码衍生自MAGE肿瘤排斥抗原前体的非肽的分离的核酸分子。 非肽与细胞表面呈现的人白细胞抗原形成复合物，并导致细胞溶解性T淋巴细胞裂解这些细胞。 因此，它们在诊断方法中是有用的。 本发明的一部分也是设计用于编码已经用本发明的分离的核酸分子转化或转染的非肽以及包含这些分子的载体的细胞系的载体。
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公开(公告)号：US06710172B1
公开(公告)日：2004-03-23
申请号：US09806769
申请日：2001-07-30
申请人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
发明人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
IPC分类号： C07H2104
CPC分类号： C07K14/4748
摘要： The present invention relates to nucleic acid molecules encoding antigenic peptides from MAGE molecules that bind to HLA. An example of the nucleic acid molecules of the present invention is a nucleic acid molecule coding for the peptide GVYDGREHTV (SEQ ID NO: 44), which peptide binds to HLA-A2. The nucleic acid molecules and the encoded antigenic peptides are useful for diagnosing and treating various pathological conditions.
摘要翻译： 本发明涉及编码结合HLA的MAGE分子的抗原肽的核酸分子。 本发明的核酸分子的实例是编码肽GVYDGREHTV（SEQ ID NO：44）的核酸分子，该肽与HLA-A2结合。 核酸分子和编码的抗原肽可用于诊断和治疗各种病理状况。
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公开(公告)号：US07351409B2
公开(公告)日：2008-04-01
申请号：US10753158
申请日：2004-01-07
申请人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
发明人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
CPC分类号： C07K14/4748
摘要： The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for proteins of the MAGE family. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.
摘要翻译： 本发明涉及细胞毒性T淋巴细胞（CTL）克隆的分离。 特别地，本发明涉及对MAGE家族的蛋白质特异的分离的CTL克隆。 本发明的CTL克隆已经通过连续的步骤来刺激和测试淋巴细胞来分离，所述抗原呈递细胞提供来自不同表达系统的抗原，例如来自重组耶尔森氏菌，重组沙门氏菌或重组病毒。 本发明还涉及被分离的CTL克隆识别的抗原肽以及肽/ HLA复合物。
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