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    Simultaneous aspirator and dispenser for multiwell plates and similar devices
    1.
    发明授权
    Simultaneous aspirator and dispenser for multiwell plates and similar devices 失效
    用于多孔板和类似装置的同时抽吸器和分配器

    公开(公告)号：US07832291B2

    公开(公告)日：2010-11-16

    申请号：US12460288

    申请日：2009-07-15

    申请人： Lance G. Laing ,  Timothy F. Smith ,  John Gerstenmeier, III ,  Gangadhar Jogikalmath

    发明人： Lance G. Laing ,  Timothy F. Smith ,  John Gerstenmeier, III ,  Gangadhar Jogikalmath

    IPC分类号： G01N1/00

    CPC分类号： G01N35/1074 ,  G01N35/1011

    摘要： A method of making a measurement of binding affinity of a sample comprises the steps of: introducing the sample into a well having a bottom formed as a photonic crystal biosensor, wherein a portion of the sample becomes bound to the biosensor; making a measurement of the change in the shift in peak wavelength value as a function of time (kon) from the well as the sample is introduced into the well; simultaneously dispensing the sample to the well and aspirating the sample from the well and measuring the change in the shift in peak wavelength value as a function of time (koff) during the simultaneous dispensing and aspirating, and calculating an equilibrium association constant or an equilibrium dissociation constant for the sample from the values of kon and koff.

    摘要翻译： 测量样品的结合亲和力的方法包括以下步骤：将样品导入具有形成为光子晶体生物传感器的底部的孔中，其中样品的一部分与生物传感器结合; 在将样品引入到井中时，测量作为时间（kon）的函数的峰值波长值的偏移的变化; 同时将样品分配到孔中并从孔中吸出样品，并测量在同时分配和抽吸期间作为时间（k off）的函数的峰值波长值的偏移的变化，并计算平衡缔合常数或平衡解离 从kon和koff的值得到样本的常数。

    Simultaneous aspirator and dispenser for multiwell plates and similar devices
    2.
    发明申请
    Simultaneous aspirator and dispenser for multiwell plates and similar devices 失效
    用于多孔板和类似装置的同时抽吸器和分配器

    公开(公告)号：US20090282931A1

    公开(公告)日：2009-11-19

    申请号：US12460288

    申请日：2009-07-15

    申请人： Lance G. Laing ,  Timothy F. Smith ,  John Gerstenmeier, III ,  Gangadhar Jogikalmath

    发明人： Lance G. Laing ,  Timothy F. Smith ,  John Gerstenmeier, III ,  Gangadhar Jogikalmath

    IPC分类号： G01N1/00

    CPC分类号： G01N35/1074 ,  G01N35/1011

    摘要： A method of making a measurement of binding affinity of a sample comprises the steps of: introducing the sample into a well having a bottom formed as a photonic crystal biosensor, wherein a portion of the sample becomes bound to the biosensor; making a measurement of the change in the shift in peak wavelength value as a function of time (kon) from the well as the sample is introduced into the well; simultaneously dispensing the sample to the well and aspirating the sample from the well and measuring the change in the shift in peak wavelength value as a function of time (koff) during the simultaneous dispensing and aspirating, and calculating an equilibrium association constant or an equilibrium dissociation constant for the sample from the values of kon and koff.

    摘要翻译： 测量样品的结合亲和力的方法包括以下步骤：将样品导入具有形成为光子晶体生物传感器的底部的孔中，其中样品的一部分与生物传感器结合; 在将样品引入到井中时，测量作为时间（kon）的函数的峰值波长值的偏移的变化; 同时将样品分配到孔中并从孔中吸出样品，并测量在同时分配和抽吸期间作为时间（k off）的函数的峰值波长值的偏移的变化，并计算平衡缔合常数或平衡解离 从kon和koff的值得到样本的常数。

    Simultaneous aspirator and dispenser for multiwell plates and similar devices
    3.
    发明授权
    Simultaneous aspirator and dispenser for multiwell plates and similar devices 失效
    用于多孔板和类似装置的同时抽吸器和分配器

    公开(公告)号：US08061220B2

    公开(公告)日：2011-11-22

    申请号：US12589446

    申请日：2009-10-23

    申请人： Lance G. Laing ,  Timothy F. Smith ,  John Gerstenmeier, III ,  Gangadhar Jogikalmath

    发明人： Lance G. Laing ,  Timothy F. Smith ,  John Gerstenmeier, III ,  Gangadhar Jogikalmath

    IPC分类号： G01N1/00

    CPC分类号： G01N35/1074 ,  G01N35/1011

    摘要： A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate.

    摘要翻译： 一种用于将含有样品的溶液同时分配到测试装置并从该装置抽吸样品的装置。 在一个实施例中，该装置是手持式的并且包括控制机构，例如用于激活样品的分配和抽吸的按钮。 测试装置可以采用具有排成行和列的多个孔的多孔板的形式，阱的底部形成为光子晶体生物传感器。 该装置可以配置有分配和抽吸歧管以及相关联的分配和抽吸端口，这些端口位于沿着一列或多列井的所有井中，以便同时吸取并将溶液分配给该多层的一列或多列的所有孔 - 板。

    Simultaneous aspirator and dispenser for multiwell plates and similar devices
    4.
    发明申请
    Simultaneous aspirator and dispenser for multiwell plates and similar devices 失效
    用于多孔板和类似装置的同时抽吸器和分配器

    公开(公告)号：US20100043571A1

    公开(公告)日：2010-02-25

    申请号：US12589446

    申请日：2009-10-23

    申请人： Lance G. Laing ,  Timothy F. Smith ,  John Gerstenmeier, III ,  Gangadhar Jogikalmath

    发明人： Lance G. Laing ,  Timothy F. Smith ,  John Gerstenmeier, III ,  Gangadhar Jogikalmath

    IPC分类号： G01N1/00

    CPC分类号： G01N35/1074 ,  G01N35/1011

    摘要： A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate.

    摘要翻译： 一种用于将含有样品的溶液同时分配到测试装置并从该装置抽吸样品的装置。 在一个实施例中，该装置是手持式的并且包括控制机构，例如用于激活样品的分配和抽吸的按钮。 测试装置可以采用具有排成行和列的多个孔的多孔板的形式，阱的底部形成为光子晶体生物传感器。 该装置可以配置有分配和抽吸歧管以及相关联的分配和抽吸端口，这些端口位于沿着一列或多列井的所有井中，以便同时吸取并将溶液分配给该多层的一列或多列的所有孔 - 板。

    Simultaneous aspirator and dispenser for multiwell plates and similar devices
    5.
    发明申请
    Simultaneous aspirator and dispenser for multiwell plates and similar devices 失效
    用于多孔板和类似装置的同时抽吸器和分配器

    公开(公告)号：US20080115567A1

    公开(公告)日：2008-05-22

    申请号：US11601020

    申请日：2006-11-17

    申请人： Lance G. Laing ,  Timothy F. Smith ,  John Gerstenmaier ,  Gangadhar Jogikalmath

    发明人： Lance G. Laing ,  Timothy F. Smith ,  John Gerstenmaier ,  Gangadhar Jogikalmath

    IPC分类号： B01L11/00 ,  G01N33/00

    CPC分类号： G01N35/1074 ,  G01N35/1011

    摘要： A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate.

    摘要翻译： 一种用于将含有样品的溶液同时分配到测试装置并从该装置抽吸样品的装置。 在一个实施例中，该装置是手持式的并且包括控制机构，例如用于激活样品的分配和抽吸的按钮。 测试装置可以采用具有排成行和列的多个孔的多孔板的形式，阱的底部形成为光子晶体生物传感器。 该装置可以配置有分配和抽吸歧管以及相关联的分配和抽吸端口，这些端口位于沿着一列或多列井的所有井中，以便同时吸取并将溶液分配给该多层的一列或多列的所有孔 - 板。

    Simultaneous aspirator and dispenser for multiwell plates and similar devices
    6.
    发明授权
    Simultaneous aspirator and dispenser for multiwell plates and similar devices 失效
    用于多孔板和类似装置的同时抽吸器和分配器

    公开(公告)号：US07628085B2

    公开(公告)日：2009-12-08

    申请号：US11601020

    申请日：2006-11-17

    申请人： Lance G. Laing ,  Timothy F. Smith ,  John Gerstenmaier, III ,  Gangadhar Jogikalmath

    发明人： Lance G. Laing ,  Timothy F. Smith ,  John Gerstenmaier, III ,  Gangadhar Jogikalmath

    IPC分类号： G01N1/00

    CPC分类号： G01N35/1074 ,  G01N35/1011

    摘要： A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate.

    摘要翻译： 一种用于将含有样品的溶液同时分配到测试装置并从该装置抽吸样品的装置。 在一个实施例中，该装置是手持式的并且包括控制机构，例如用于激活样品的分配和抽吸的按钮。 测试装置可以采用具有排成行和列的多个孔的多孔板的形式，阱的底部形成为光子晶体生物传感器。 该装置可以配置有分配和抽吸歧管以及相关联的分配和抽吸端口，这些端口位于沿着一列或多列井的所有井中，以便同时吸取并将溶液分配给该多层的一列或多列的所有孔 - 板。