公开(公告)号：US20100196925A1

公开(公告)日：2010-08-05

申请号：US12758928

申请日：2010-04-13

申请人： Christine C. Genick ,  Lance G. Laing ,  Peter Li ,  Timothy F. Smith ,  Lara Madison ,  William C. Karl ,  Bo Lin

发明人： Christine C. Genick ,  Lance G. Laing ,  Peter Li ,  Timothy F. Smith ,  Lara Madison ,  William C. Karl ,  Bo Lin

IPC分类号： G01N33/53 ,  C12Q1/02

CPC分类号： G01N33/543 ,  B01L3/5085 ,  C12Q1/6816 ,  C40B30/04 ,  C40B30/10 ,  G01N21/253 ,  G01N21/255 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/5026 ,  G01N33/5029 ,  G01N33/5032 ,  G01N33/54366 ,  G01N33/54373 ,  G02B5/1809 ,  Y10S436/805 ,  Y10S436/809

摘要： The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.

摘要翻译： 本发明提供检测细胞生长模式变化的方法，在一个容器中筛选许多不同抗体的方法，以及检测抗体与蛋白质或细胞的特异性结合的方法，其中所述抗体是许多不同抗体的混合物。

公开(公告)号：US06614030B2

公开(公告)日：2003-09-02

申请号：US10147940

申请日：2002-05-15

申请人： Kevin Maher ,  Timothy F. Smith ,  Torleif Ove Bjornson

发明人： Kevin Maher ,  Timothy F. Smith ,  Torleif Ove Bjornson

IPC分类号： G01N2164

CPC分类号： G01N21/6452 ,  B01L3/5027 ,  B01L2200/14 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6478 ,  G01N2201/101

摘要： An optical detection and orientation device is provided comprising housing having an excitation light source, an optical element for reflecting the excitation light to an aspherical lens and transmitting light emitted by a fluorophore excited by said excitation light, a focussing lens for focusing the emitted light onto the entry of an optical fiber, which serves as a confocal aperture, and means for accurately moving said housing over a small area in relation to a channel in a microfluidic device. The optical detection and orientation device finds use in identifying the center of the channel and detecting fluorophores in the channel during operations involving fluorescent signals.

公开(公告)号：US06284113B1

公开(公告)日：2001-09-04

申请号：US09153814

申请日：1998-09-15

申请人： Torleif Ove Bjornson ,  Timothy F. Smith

发明人： Torleif Ove Bjornson ,  Timothy F. Smith

IPC分类号： G01N2726

CPC分类号： B01L3/0268 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00358 ,  C40B60/14 ,  G01N35/1065 ,  G01N35/1074 ,  G01N2035/1037

摘要： The present invention concerns devices, apparatus and methods for transferring liquids. One aspect of the present invention is a device comprising a plate having a plurality of transfer elements. Each of the transfer elements comprises an aperture in the plate where the aperture is capable of being electrically activated. The plate has one of more attaching elements for attaching the plate to a multiwell plate to form a sealed system except for the apertures of the transfer elements. Usually, the device is adapted for sealing attachment to a multiwell plate. In a method in accordance with the present invention a quantity of liquid is disposed to a second side of a plate having a plurality of apertures in the plate. The apertures are capable of being electrically activated. The liquid is present in a closed well except for the apertures in the plate. To simultaneously expel liquid from the apertures, the apertures are electrically activated. Also disclosed are kits comprising a device in accordance with the present invention.

摘要翻译： 本发明涉及用于转移液体的装置，装置和方法。 本发明的一个方面是包括具有多个转移元件的板的装置。 每个传送元件包括板中的孔，其中孔能够被电激活。 板具有用于将板连接到多孔板以形成除了转移元件的孔之外的密封系统的更多附接元件之一。 通常，该装置适于密封附着到多孔板。 在根据本发明的方法中，一定量的液体被设置在板的具有多个孔的板的第二面上。 孔能够被电活动。 除了板中的孔之外，液体存在于封闭的井中。 为了同时从孔中排出液体，孔被电激活。 还公开了包括根据本发明的装置的试剂盒。

公开(公告)号：US08551716B2

公开(公告)日：2013-10-08

申请号：US13527072

申请日：2012-06-19

申请人： Christine C. Genick ,  Lance G. Laing ,  Peter Li ,  Timothy F. Smith ,  Lara Madison ,  Bo Lin

发明人： Christine C. Genick ,  Lance G. Laing ,  Peter Li ,  Timothy F. Smith ,  Lara Madison ,  Bo Lin

IPC分类号： G01N33/53

CPC分类号： G01N33/543 ,  B01L3/5085 ,  C12Q1/6816 ,  C40B30/04 ,  C40B30/10 ,  G01N21/253 ,  G01N21/255 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/5026 ,  G01N33/5029 ,  G01N33/5032 ,  G01N33/54366 ,  G01N33/54373 ,  G02B5/1809 ,  Y10S436/805 ,  Y10S436/809

摘要： The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.

摘要翻译： 本发明提供检测细胞生长模式变化的方法，在一个容器中筛选许多不同抗体的方法，以及检测抗体与蛋白质或细胞的特异性结合的方法，其中所述抗体是许多不同抗体的混合物。

公开(公告)号：US20130130926A1

公开(公告)日：2013-05-23

申请号：US13527072

申请日：2012-06-19

申请人： Christine C. Genick ,  Lance G. Laing ,  Peter Li ,  Timothy F. Smith ,  Lara Madison ,  William C. Karl ,  Bo Lin

发明人： Christine C. Genick ,  Lance G. Laing ,  Peter Li ,  Timothy F. Smith ,  Lara Madison ,  William C. Karl ,  Bo Lin

IPC分类号： G01N33/543

CPC分类号： G01N33/543 ,  B01L3/5085 ,  C12Q1/6816 ,  C40B30/04 ,  C40B30/10 ,  G01N21/253 ,  G01N21/255 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/5026 ,  G01N33/5029 ,  G01N33/5032 ,  G01N33/54366 ,  G01N33/54373 ,  G02B5/1809 ,  Y10S436/805 ,  Y10S436/809

摘要： The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.

摘要翻译： 本发明提供检测细胞生长模式变化的方法，在一个容器中筛选许多不同抗体的方法，以及检测抗体与蛋白质或细胞的特异性结合的方法，其中所述抗体是许多不同抗体的混合物。

公开(公告)号：US08061220B2

公开(公告)日：2011-11-22

申请号：US12589446

申请日：2009-10-23

申请人： Lance G. Laing ,  Timothy F. Smith ,  John Gerstenmeier, III ,  Gangadhar Jogikalmath

发明人： Lance G. Laing ,  Timothy F. Smith ,  John Gerstenmeier, III ,  Gangadhar Jogikalmath

IPC分类号： G01N1/00

CPC分类号： G01N35/1074 ,  G01N35/1011

摘要： A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate.

摘要翻译： 一种用于将含有样品的溶液同时分配到测试装置并从该装置抽吸样品的装置。 在一个实施例中，该装置是手持式的并且包括控制机构，例如用于激活样品的分配和抽吸的按钮。 测试装置可以采用具有排成行和列的多个孔的多孔板的形式，阱的底部形成为光子晶体生物传感器。 该装置可以配置有分配和抽吸歧管以及相关联的分配和抽吸端口，这些端口位于沿着一列或多列井的所有井中，以便同时吸取并将溶液分配给该多层的一列或多列的所有孔 - 板。

公开(公告)号：US20100043571A1

公开(公告)日：2010-02-25

申请号：US12589446

申请日：2009-10-23

申请人： Lance G. Laing ,  Timothy F. Smith ,  John Gerstenmeier, III ,  Gangadhar Jogikalmath

发明人： Lance G. Laing ,  Timothy F. Smith ,  John Gerstenmeier, III ,  Gangadhar Jogikalmath

IPC分类号： G01N1/00

CPC分类号： G01N35/1074 ,  G01N35/1011

摘要： A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate.

摘要翻译： 一种用于将含有样品的溶液同时分配到测试装置并从该装置抽吸样品的装置。 在一个实施例中，该装置是手持式的并且包括控制机构，例如用于激活样品的分配和抽吸的按钮。 测试装置可以采用具有排成行和列的多个孔的多孔板的形式，阱的底部形成为光子晶体生物传感器。 该装置可以配置有分配和抽吸歧管以及相关联的分配和抽吸端口，这些端口位于沿着一列或多列井的所有井中，以便同时吸取并将溶液分配给该多层的一列或多列的所有孔 - 板。

公开(公告)号：US07628085B2

公开(公告)日：2009-12-08

申请号：US11601020

申请日：2006-11-17

申请人： Lance G. Laing ,  Timothy F. Smith ,  John Gerstenmaier, III ,  Gangadhar Jogikalmath

发明人： Lance G. Laing ,  Timothy F. Smith ,  John Gerstenmaier, III ,  Gangadhar Jogikalmath

IPC分类号： G01N1/00

CPC分类号： G01N35/1074 ,  G01N35/1011

摘要： A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate.

摘要翻译： 一种用于将含有样品的溶液同时分配到测试装置并从该装置抽吸样品的装置。 在一个实施例中，该装置是手持式的并且包括控制机构，例如用于激活样品的分配和抽吸的按钮。 测试装置可以采用具有排成行和列的多个孔的多孔板的形式，阱的底部形成为光子晶体生物传感器。 该装置可以配置有分配和抽吸歧管以及相关联的分配和抽吸端口，这些端口位于沿着一列或多列井的所有井中，以便同时吸取并将溶液分配给该多层的一列或多列的所有孔 - 板。

公开(公告)号：US08202735B2

公开(公告)日：2012-06-19

申请号：US12758928

申请日：2010-04-13

申请人： Christine C. Genick ,  Lance G. Laing ,  Peter Li ,  Timothy F. Smith ,  Lara Madison ,  William C. Karl ,  Bo Lin

发明人： Christine C. Genick ,  Lance G. Laing ,  Peter Li ,  Timothy F. Smith ,  Lara Madison ,  William C. Karl ,  Bo Lin

IPC分类号： G01N33/543

CPC分类号： G01N33/543 ,  B01L3/5085 ,  C12Q1/6816 ,  C40B30/04 ,  C40B30/10 ,  G01N21/253 ,  G01N21/255 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/5026 ,  G01N33/5029 ,  G01N33/5032 ,  G01N33/54366 ,  G01N33/54373 ,  G02B5/1809 ,  Y10S436/805 ,  Y10S436/809

摘要： The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.

摘要翻译： 本发明提供检测细胞生长模式变化的方法，在一个容器中筛选许多不同抗体的方法，以及检测抗体与蛋白质或细胞的特异性结合的方法，其中所述抗体是许多不同抗体的混合物。

公开(公告)号：US07927822B2

公开(公告)日：2011-04-19

申请号：US11635934

申请日：2006-12-08

申请人： Christine C. Genick ,  Lance G. Laing ,  Peter Li ,  Timothy F. Smith ,  Lara Madison ,  William C. Karl ,  Bo Lin

发明人： Christine C. Genick ,  Lance G. Laing ,  Peter Li ,  Timothy F. Smith ,  Lara Madison ,  William C. Karl ,  Bo Lin

IPC分类号： G01N33/543 ,  G01N33/545 ,  G01N33/551

CPC分类号： G01N33/543 ,  B01L3/5085 ,  C12Q1/6816 ,  C40B30/04 ,  C40B30/10 ,  G01N21/253 ,  G01N21/255 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/5026 ,  G01N33/5029 ,  G01N33/5032 ,  G01N33/54366 ,  G01N33/54373 ,  G02B5/1809 ,  Y10S436/805 ,  Y10S436/809

摘要： The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.

摘要翻译： 本发明提供检测细胞生长模式变化的方法，在一个容器中筛选许多不同抗体的方法，以及检测抗体与蛋白质或细胞的特异性结合的方法，其中所述抗体是许多不同抗体的混合物。