利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

19 条记录 (耗时 0.037 秒)

    Non-Anilinic Derivatives Of Isothiazol-3(2H)-Thione 1,1-Dioxides As Liver X Receptor Modulators
    2.
    发明申请
    Non-Anilinic Derivatives Of Isothiazol-3(2H)-Thione 1,1-Dioxides As Liver X Receptor Modulators 审中-公开
    异噻唑啉-3（2H） - 二氧化铅的非苯胺衍生物作为肝X受体调节剂

    公开(公告)号：US20080139616A1

    公开(公告)日：2008-06-12

    申请号：US11813458

    申请日：2006-01-09

    申请人： Lanna Li ,  Marianne Swanson ,  Kay Brickmann

    发明人： Lanna Li ,  Marianne Swanson ,  Kay Brickmann

    IPC分类号： A61K31/4523 ,  C07D221/00 ,  A61K31/425 ,  A61P9/00 ,  C07D275/02

    CPC分类号： C07D275/03 ,  C07D417/14

    摘要： The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) α (NR1H3) and/or β (NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.

    摘要翻译： 本发明涉及式（I）的某些新化合物，其用于制备这些化合物，用于调节核激素受体肝X受体（LXR）α（NR1H3）和/或β（NR1H2）和在 治疗和/或预防包括心血管疾病如动脉粥样硬化的临床病症; 炎性疾病，阿尔茨海默病，与胰岛素抵抗相关的脂质紊乱（血脂异常），2型糖尿病和代谢综合征的其他表现，其治疗用途的方法和含有它们的药物组合物。

    Non-Anilinic Derivatives of Isothiazol-3(2H)-Thione 1,1-Dioxides As Liver X Receptor Modulators
    5.
    发明申请
    Non-Anilinic Derivatives of Isothiazol-3(2H)-Thione 1,1-Dioxides As Liver X Receptor Modulators 审中-公开
    异噻唑啉-3（2H） - 二氧化硫作为肝X受体调节剂的非苯胺衍生物

    公开(公告)号：US20080319017A2

    公开(公告)日：2008-12-25

    申请号：US11813458

    申请日：2007-07-06

    申请人： Lanna Li ,  Marianne Swanson ,  Kay Brickmann

    发明人： Lanna Li ,  Marianne Swanson ,  Kay Brickmann

    IPC分类号： A61K31/4523 ,  C07D221/00 ,  A61K31/425 ,  A61P9/00 ,  C07D275/02

    CPC分类号： C07D275/03 ,  C07D417/14

    摘要： The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) α (NR1H3) and/or β (NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.

    摘要翻译： 本发明涉及式（I）的某些新化合物，其用于制备这些化合物，用于调节核激素受体肝X受体（LXR）α（NR1H3）和/或β（NR1H2）和在 治疗和/或预防包括心血管疾病如动脉粥样硬化的临床病症; 炎性疾病，阿尔茨海默病，与胰岛素抵抗相关的脂质紊乱（血脂异常），2型糖尿病和代谢综合征的其他表现，其治疗用途的方法和含有它们的药物组合物。

    Derivatives of Isothiazol-3(2H)-Thione 1,1-Dioxides as Liver X Receptor Modulators
    6.
    发明申请
    Derivatives of Isothiazol-3(2H)-Thione 1,1-Dioxides as Liver X Receptor Modulators 审中-公开
    作为肝X受体调节剂的异噻唑-3（2H） - 硫酮-1,2-二氧化物的衍生物

    公开(公告)号：US20080125396A1

    公开(公告)日：2008-05-29

    申请号：US11813489

    申请日：2006-01-09

    申请人： Marianne Swanson ,  Kay Brickmann ,  Lanna Li

    发明人： Marianne Swanson ,  Kay Brickmann ,  Lanna Li

    IPC分类号： A61K31/695 ,  A61K31/425 ,  C07F5/02

    CPC分类号： C07D275/03

    摘要： The present invention relates to certain novel compounds of formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) α (NR1H3) and/or β (NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.

    摘要翻译： 本发明涉及某些新的式（I）化合物，其用于制备这些化合物，用于调节核激素受体肝X受体（LXR）α（NR1H3）和/或β（NR1H2）和治疗 和/或预防包括心血管疾病如动脉粥样硬化的临床病症; 炎性疾病，阿尔茨海默病，与胰岛素抵抗相关的脂质紊乱（血脂异常），2型糖尿病和代谢综合征的其他表现，其治疗用途的方法和含有它们的药物组合物。

    Non-Anilinic Derivatives of Isothiazol-3(2H)-Thione 1,1-Dioxides As Liver X Receptor Modulators
    9.
    发明申请
    Non-Anilinic Derivatives of Isothiazol-3(2H)-Thione 1,1-Dioxides As Liver X Receptor Modulators 审中-公开
    异噻唑啉-3（2H） - 二氧化硫作为肝X受体调节剂的非苯胺衍生物

    公开(公告)号：US20090029945A2

    公开(公告)日：2009-01-29

    申请号：US11813489

    申请日：2007-07-06

    申请人： Marianne Swanson ,  Kay Brickmann ,  Lanna Li

    发明人： Marianne Swanson ,  Kay Brickmann ,  Lanna Li

    IPC分类号： A61K31/695 ,  A61K31/425 ,  C07F5/02

    CPC分类号： C07D275/03

    摘要： The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) α (NR1H3) and/or β (NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.

    摘要翻译： 本发明涉及式（I）的某些新化合物，其用于制备这些化合物，用于调节核激素受体肝X受体（LXR）α（NR1H3）和/或β（NR1H2）和在 治疗和/或预防包括心血管疾病如动脉粥样硬化的临床病症; 炎性疾病，阿尔茨海默病，与胰岛素抵抗相关的脂质紊乱（血脂异常），2型糖尿病和代谢综合征的其他表现，其治疗用途的方法和含有它们的药物组合物。