公开(公告)号：US20240148850A1

公开(公告)日：2024-05-09

申请号：US17997749

申请日：2022-03-17

申请人： Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

发明人： Jing ZHANG ,  Zengjun LU ,  Kun LI ,  Pu SUN ,  Jian WANG ,  Yimei CAO ,  Huifang BAO ,  Zhixun ZHAO ,  Pinghua LI ,  Yuanfang FU ,  Xueqing MA ,  Hong YUAN ,  Xingwen BAI ,  Qiang ZHANG ,  Dong LI ,  Zaixin LIU

IPC分类号： A61K39/12 ,  A61K39/00 ,  C07K14/005 ,  G01N33/569

CPC分类号： A61K39/12 ,  C07K14/005 ,  G01N33/56983 ,  A61K2039/5252 ,  A61K2039/5254 ,  C12N2770/10022 ,  C12N2770/10034 ,  G01N2333/08

摘要： The present disclosure provides an N protein epitope mutation marker for preparing an epitope deletion-marked vaccine strain of type II porcine reproductive and respiratory syndrome virus (PRRSV) and use thereof, belonging to the technical field of biological products. In the mutation marker, one or more amino acids are mutated based on an epitope sequence at positions 92 to 103 of a C-terminal of an N protein of the type II PRRSV; and the epitope mutation marker has an amino acid sequence shown in SEQ ID NO: 1, where X1 is selected from the group consisting of T, P, and A; and X2 is selected from the group consisting of V and A.