-
1.发明授权Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes 有权用于预防和/或逆转新发型自身免疫性糖尿病的基于微球的组合物公开(公告)号：US08389493B2
公开(公告)日：2013-03-05
申请号：US13103433
申请日：2011-05-09
IPC分类号： A61K48/00
CPC分类号： A61K31/7088 , A61K9/0024 , A61K9/1641 , A61K9/19 , A61K38/28 , C12N15/111 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2320/32 , A61K2300/00
摘要： AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to reverse an autoimmune diabetes condition in NOD mice in vivo. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
摘要翻译： AS寡核苷酸以微球形式递送，以诱导树突细胞耐受，特别是在非肥胖 - 糖尿病（NOD）小鼠模型中。 微球合并反义（AS）寡核苷酸。 一种方法包括使用反义方法在体内逆转NOD小鼠的自身免疫性糖尿病状态。 靶向寡核苷酸以结合初级转录物CD40，CD80，CD86及其组合。
-
2.发明授权Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes 有权用于预防和/或逆转新发型自身免疫性糖尿病的基于微球的组合物公开(公告)号：US07964574B2
公开(公告)日：2011-06-21
申请号：US11834550
申请日：2007-08-06
IPC分类号： A61K48/00
CPC分类号： A61K31/7088 , A61K9/0024 , A61K9/1641 , A61K9/19 , A61K38/28 , C12N15/111 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2320/32 , A61K2300/00
摘要： AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to reverse an autoimmune diabetes condition in NOD mice in vivo. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
摘要翻译： AS寡核苷酸以微球形式递送，以诱导树突细胞耐受，特别是在非肥胖 - 糖尿病（NOD）小鼠模型中。 微球合并反义（AS）寡核苷酸。 一种方法包括使用反义方法在体内逆转NOD小鼠中的自身免疫性糖尿病状态。 靶向寡核苷酸以结合初级转录物CD40，CD80，CD86及其组合。
-
3.发明申请MICROSPHERE-BASED COMPOSITION FOR PREVENTING AND/OR REVERSING NEW-ONSET AUTOIMMUNE DIABETES 有权用于预防和/或逆转新型自动免疫糖尿病的基于微阵列的组合物公开(公告)号：US20110274758A1
公开(公告)日：2011-11-10
申请号：US13103433
申请日：2011-05-09
IPC分类号： A61K31/711 , A61P3/10 , A61K38/28 , A61K9/14
CPC分类号： A61K31/7088 , A61K9/0024 , A61K9/1641 , A61K9/19 , A61K38/28 , C12N15/111 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2320/32 , A61K2300/00
摘要： AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to reverse an autoimmune diabetes condition in NOD mice in vivo. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
摘要翻译： AS寡核苷酸以微球形式递送，以诱导树突细胞耐受，特别是在非肥胖 - 糖尿病（NOD）小鼠模型中。 微球合并反义（AS）寡核苷酸。 一种方法包括使用反义方法在体内逆转NOD小鼠中的自身免疫性糖尿病状态。 靶向寡核苷酸以结合初级转录物CD40，CD80，CD86及其组合。
-
4.发明申请MICROSPHERE-BASED COMPOSITION FOR PREVENTING AND/OR REVERSING NEW-ONSET AUTOIMMUNE DIABETES 有权用于预防和/或逆转新型自动免疫糖尿病的基于微阵列的组合物公开(公告)号：US20090291145A1
公开(公告)日：2009-11-26
申请号：US12426904
申请日：2009-04-20
IPC分类号： A61K9/50 , A61K31/7105
CPC分类号： C12N15/88 , C12N15/1138 , C12N2310/11 , C12N2320/32
摘要： A method is provided that includes using an antisense approach to reverse and/or delay an autoimmune diabetes condition in vivo. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
摘要翻译： 提供了一种方法，其包括使用反义方法在体内逆转和/或延迟自身免疫性糖尿病状态。 靶向寡核苷酸以结合初级转录物CD40，CD80，CD86及其组合。
-
5.发明授权Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes 有权用于预防和/或逆转新发型自身免疫性糖尿病的基于微球的组合物公开(公告)号：US08022046B2
公开(公告)日：2011-09-20
申请号：US12426904
申请日：2009-04-20
CPC分类号： C12N15/88 , C12N15/1138 , C12N2310/11 , C12N2320/32
摘要： A method is provided that includes using an antisense approach to reverse and/or delay an autoimmune diabetes condition in vivo. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
摘要翻译： 提供了一种方法，其包括使用反义方法在体内逆转和/或延迟自身免疫性糖尿病状态。 靶向寡核苷酸以结合初级转录物CD40，CD80，CD86及其组合。
-
6.发明授权Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes 有权递送AS-寡核苷酸微球以诱导树突细胞耐受治疗自身免疫性1型糖尿病公开(公告)号：US09115357B2
公开(公告)日：2015-08-25
申请号：US12822774
申请日：2010-06-24
申请人： Larry R. Brown , Vered Bisker-Leib , Terrence L. Scott , Debra Lafreniere , Jennifer Machen , Nick Giannoukakis
发明人： Larry R. Brown , Vered Bisker-Leib , Terrence L. Scott , Debra Lafreniere , Jennifer Machen , Nick Giannoukakis
IPC分类号： A61K31/711 , A61K9/14 , A61K31/7088 , A61P3/10 , A61P37/06 , C12N15/113 , A61K9/00 , A61K9/16 , A61K9/19 , C12N15/11
CPC分类号： C12N15/1138 , A61K9/0019 , A61K9/1635 , A61K9/1641 , A61K9/1658 , A61K9/19 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2320/32
摘要： AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to prevent an autoimmune diabetes condition in NOD mice in vivo and in situ. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
摘要翻译： AS寡核苷酸以微球形式递送，以诱导树突细胞耐受，特别是在非肥胖 - 糖尿病（NOD）小鼠模型中。 微球合并反义（AS）寡核苷酸。 一种方法包括使用反义方法在体内和原位抑制NOD小鼠中的自身免疫性糖尿病状况。 靶向寡核苷酸以结合初级转录物CD40，CD80，CD86及其组合。
-
7.发明申请DELIVERY OF AS-OLIGONUCLEOTIDE MICROSPHERES TO INDUCE DENDRITIC CELL TOLERANCE FOR THE TREATMENT OF AUTOIMMUNE TYPE 1 DIABETES 有权递送AS-OLIGONUCLEOTIDE MICROSPHERES以诱导用于治疗自身免疫型1型糖尿病的DENDRITIC CELL ROLERANCE公开(公告)号：US20100260855A1
公开(公告)日：2010-10-14
申请号：US12822774
申请日：2010-06-24
申请人： Larry R. Brown , Vered Bisker-Leib , Terrence L. Scott , Debra Lafreniere , Jennifer Machen , Nick Giannoukakis
发明人： Larry R. Brown , Vered Bisker-Leib , Terrence L. Scott , Debra Lafreniere , Jennifer Machen , Nick Giannoukakis
IPC分类号： A61K31/711 , A61K9/14 , A61K31/7088 , A61P3/10 , A61P37/06
CPC分类号： C12N15/1138 , A61K9/0019 , A61K9/1635 , A61K9/1641 , A61K9/1658 , A61K9/19 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2320/32
摘要： AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to prevent an autoimmune diabetes condition in NOD mice in vivo and in situ. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
摘要翻译： AS寡核苷酸以微球形式递送，以诱导树突细胞耐受，特别是在非肥胖 - 糖尿病（NOD）小鼠模型中。 微球合并反义（AS）寡核苷酸。 一种方法包括使用反义方法在体内和原位抑制NOD小鼠中的自身免疫性糖尿病状况。 靶向寡核苷酸以结合初级转录物CD40，CD80，CD86及其组合。
-
公开(公告)号：US08808747B2
公开(公告)日：2014-08-19
申请号：US12105213
申请日：2008-04-17
CPC分类号： A61K9/50 , A61K9/0075 , A61K9/1611 , A61K9/1617 , A61K9/1688 , A61K9/5031 , A61K38/28
摘要： The present disclosure is related to microparticle compositions, in which the microparticles are made of nucleic acids and non-polymeric cations, which are suitable for administration to moist or aqueous target locations (e.g., the lung tissue), where the substantially spherical nucleic acid microparticles release the nucleic acids through dissolution, allowing the released nucleic acids to freely interact with the target cells.
摘要翻译： 本公开内容涉及微粒组合物，其中微粒由核酸和非聚合阳离子制成，其适用于向湿或水性靶位置（例如，肺组织）施用，其中基本上球形的核酸微粒 通过溶解释放核酸，允许释放的核酸与靶细胞自由相互作用。
-
公开(公告)号：US20090017124A1
公开(公告)日：2009-01-15
申请号：US12105213
申请日：2008-04-17
IPC分类号： A61K9/14 , A61K31/7088
CPC分类号： A61K9/50 , A61K9/0075 , A61K9/1611 , A61K9/1617 , A61K9/1688 , A61K9/5031 , A61K38/28
摘要： The present disclosure is related to microparticle compositions, in which the microparticles are made of nucleic acids and non-polymeric cations, which are suitable for administration to moist or aqueous target locations (e.g., the lung tissue), where the substantially spherical nucleic acid microparticles release the nucleic acids through dissolution, allowing the released nucleic acids to freely interact with the target cells.
摘要翻译： 本公开内容涉及微粒组合物，其中微粒由核酸和非聚合阳离子制成，其适用于向湿或水性靶位置（例如，肺组织）施用，其中基本上球形的核酸微粒 通过溶解释放核酸，允许释放的核酸与靶细胞自由相互作用。
-
10.发明授权公开(公告)号：US07081600B2
公开(公告)日：2006-07-25
申请号：US11103059
申请日：2005-04-11
CPC分类号： B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2300/046 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844
摘要： A flexible heating cover assembly for an apparatus for heating samples of biological material with substantial temperature uniformity includes a housing having a plurality of engageable enclosure components; a resistive heater having a plurality of heater element areas; a heater backing plate providing stability to the resistive heater; a force distribution system that distributes a force over the heater backing plate; and a support plate providing stiffness for the force distribution system, wherein the arrangement of the resistive heater, the heater backing plate, the force distribution system and the support plate provide substantial temperature uniformity among a plurality of sample tubes for receiving samples of biological material. The flexible heating cover assembly improves the uniformity, efficiency, quality, reliability and controllability of the thermal response during thermal cycling of the biological material.
摘要翻译： 一种用于加热具有显着温度均匀性的生物材料样品的装置的柔性加热盖组件包括具有多个可接合外壳部件的壳体; 电阻加热器，具有多个加热元件区域; 加热器背板，为电阻加热器提供稳定性; 力分配系统，其在加热器背板上分布力; 以及为力分配系统提供刚度的支撑板，其中电阻加热器，加热器背板，力分配系统和支撑板的布置在用于接收生物材料样品的多个样品管之间提供显着的温度均匀性。 柔性加热盖组件改善了生物材料热循环期间的热响应的均匀性，效率，质量，可靠性和可控性。
-
-
-
-
-
-
-
-
-
搜索结果
31 条记录 (耗时 0.03 秒)
