公开(公告)号：US3956312A

公开(公告)日：1976-05-11

申请号：US497676

申请日：1974-08-15

申请人： Laszlo Magdanyi ,  Lujza Petocz ,  Eniko Kiszelly ,  Ibolya Kosoczky ,  Attila Varga

发明人： Laszlo Magdanyi ,  Lujza Petocz ,  Eniko Kiszelly ,  Ibolya Kosoczky ,  Attila Varga

IPC分类号： C07D231/54 ,  A61K31/13 ,  A61K31/395 ,  A61K31/415 ,  A61K31/416 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61P1/04 ,  A61P25/24 ,  A61P25/26 ,  C07D231/56 ,  C07D401/12 ,  C07D405/12

CPC分类号： C07D231/56 ,  A61K31/415

摘要： New compounds of the general formula (I) ##SPC1##and salts thereof were prepared by reacting a compound of the general formula (II) ##SPC2##with a compound of the general formula (III) or (IV) ##EQU1## and optionally saturating the --C=N-- bond. In the above formulaeR.sup.1 and R.sup.2 are always the same and represent a C.sub.1-4 alkyl group,R.sup.3 stands for hydrogen,R.sup.4 and R.sup.5 each represent hydrogen or a straight-chained or branched C.sub.1-16 alkyl group optionally having an unsubstituted or substituted phenyl, furyl or naphthyl substituent, wherein said substituted aryl groups may contain up to 3 alkyl, C.sub.1-3 alkoxy, benzyloxy, nitro, amino, lower alkylamino, di-lower alkylamino, methylenedioxy, alkylmercapto, alkylsulfonyl or halogen substituents, orR.sup.4 and R.sup.5 may form together with the adjacent carbon atom a C.sub.3-12 cycloalkyl or C.sub.3-12 cycloalkylidene group, one of the methylene ring members of which being optionally replaced by an imino, lower alkylimino, or phenyl-lower alkylimino group, andR.sup.6 and R.sup.7 may stand for hydrogen, or R.sup.6 and R.sup.7 may form together a valence bond, andThe R.sup.8 groups may each represent hydrogen, lower alkyl or alkanoyl, or the two R.sup.8 groups may form together a lower alkylene or alkanoylene group.The compounds of the general formula (I) possess primarily gastric acid secretion inhibiting and central nervous activities, furthermore they exert favourable action on the development of certain microorganisms which can be utilized in therapy.

摘要翻译： 通式（I）的新化合物及其盐通过使通式（II）的化合物与通式（III）或（IV）的化合物反应，R 5 = C（R）R 8 R 5 R 5 （IV）R8OR4并且任选地饱和-C = N-键。

公开(公告)号：US4342762A

公开(公告)日：1982-08-03

申请号：US215154

申请日：1980-12-11

申请人： Zoltan Budai ,  Laszlo Magdanyi ,  Aranka Lay nee Konya ,  Tibor Mezei ,  Katalin Grasser ,  Lujza Petocz ,  Ibolya Kosoczky

发明人： Zoltan Budai ,  Laszlo Magdanyi ,  Aranka Lay nee Konya ,  Tibor Mezei ,  Katalin Grasser ,  Lujza Petocz ,  Ibolya Kosoczky

IPC分类号： A61K31/13 ,  A61K31/135 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/431 ,  A61K31/495 ,  A61K31/535 ,  A61K31/5375 ,  A61P25/00 ,  A61P25/04 ,  A61P25/08 ,  A61P25/20 ,  A61P29/00 ,  C07C67/00 ,  C07C213/00 ,  C07C217/00 ,  C07C217/04 ,  C07C217/12 ,  C07C217/26 ,  C07C217/52 ,  C07D295/03 ,  C07D295/08 ,  C07D295/088 ,  C07D333/16 ,  A61K31/54 ,  A61K31/445 ,  C07D245/02

CPC分类号： C07D295/088 ,  C07D333/16

摘要： The invention relates to novel basic ethers of the general formula /I/ and pharmaceutically acceptable acid addition salts and quaternary salts thereof, ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and represent a C.sub.1-5 alkyl group or a C.sub.3-6 cycloalkyl group or they form, together with the adjacent nitrogen atom, a heterocyclic ring containing 4-7 carbon atoms and optionally a further hetero atom, e.g. an oxygen, sulfur or nitrogen atom, and this latter may be optionally substituted by a C.sub.1-3 alkyl, benzyl or phenyl group,R represents a phenyl, phenyl-/C.sub.1-3 alkyl/ or thienyl group optionally substituted by one or more halogen or C.sub.1-3 alkoxy substituent/s/,A represents a C.sub.2-5 straight or branched alkylene chain, and represents a valence bond of .alpha. or .beta. configuration.The new compounds of the general formula /I/ possess valuable anticonvulsive, motility inhibiting, hexobarbital narcose potentiating and analgesic effects, which are, in case of certain compounds, complemented by week antiserotonine, gastro-intestinal-tract inhibiting and antiinflammatory effects, and can be applied to advantage in the therapy.

摘要翻译： 本发明涉及通式I I和其药学上可接受的酸加成盐和季盐的新型碱性醚，其中R 1和R 2可以相同或不同，表示C 1-5烷基或 与相邻的氮原子一起形成含有4-7个碳原子和任选的另外的杂原子的杂环，例如 氧，硫或氮原子，并且后者可任选被C 1-3烷基，苄基或苯基取代，R表示任选被一个或多个卤素取代的苯基，苯基 - / C 1-3烷基或噻吩基 或C 1-3烷氧基取代基/ s，A表示C 2-5直链或支链亚烷基链，并且表示α或β构型的价键。 新化合物的通式I /具有有价值的抗惊厥，运动抑制，六硼麻醉加强镇痛作用，在某些化合物的情况下，辅以一周抗塞冬糖，胃肠道抑制和抗炎作用，并且可以 适用于治疗的优势。

公开(公告)号：US4232136A

公开(公告)日：1980-11-04

申请号：US15736

申请日：1979-02-27

申请人： Istvan Kovacsay ,  Maria Szajko nee Lorinczi ,  Istvan Dubovszky ,  Laszlo Magdanyi ,  Ferenc Szailer ,  Ede Szatmari

发明人： Istvan Kovacsay ,  Maria Szajko nee Lorinczi ,  Istvan Dubovszky ,  Laszlo Magdanyi ,  Ferenc Szailer ,  Ede Szatmari

IPC分类号： C08F299/04 ,  C08F2/44 ,  C08K5/29 ,  G01N22/00 ,  C08F18/00 ,  C08F118/14

CPC分类号： C08K5/29

摘要： The invention relates to a process for the controlled hardening of unsaturated polyester resins at temperatures of -5.degree. C. to +150.degree. C. using an organic peroxide initiator. According to the process of the invention an organic dyestuff of the general formula (I), ##STR1## wherein R.sup.1 stands for a group of the general formula (II), ##STR2## and in this formula R.sup.5 is a C.sub.1-4 alkyl group and n is an integer from 1 to 3,R.sup.2 and R.sup.3 each represent a C.sub.1-4 alkyl group,R.sup.4 stands for hydrogen, orR.sup.1 and R.sup.4 form together a group of the general formula (III), ##STR3## and in this formula R.sup.6, R.sup.7 and R.sup.8 each represent hydrogen or a C.sub.1-4 alkyl group and Z stands for oxygen or sulfur atom or a -NH- group, andX stands for chlorine or bromine, is admixed with the polyester resin and/or the organic peroxide in an amount of 0.001 to 0.05% by weight, calculated for the weight of the polyester resin.Using the method of the invention the composition and homogeneity of the polyester resin/additive mixtures can be observed easily and the progress of cross-linking can be monitored visually through characteristic colors and color changes, respectively.

摘要翻译： 本发明涉及使用有机过氧化物引发剂在-5℃至+ 150℃的温度下控制硬化不饱和聚酯树脂的方法。 根据本发明的方法，通式（I）的有机染料，其中R1代表通式（Ⅱ）的基团，其中R1和R2分别是 C 1-4烷基，n为1至3的整数，R 2和R 3各自表示C 1-4烷基，R 4表示氢，或R 1和R 4一起形成通式（III）的基团， （III）中，在该式R6中，R7和R8各自表示氢或C1-4烷基，Z表示氧或硫原子或-NH-基团，X表示氯或溴，与 聚酯树脂和/或有机过氧化物，其量为聚酯树脂重量的0.001至0.05重量％。 使用本发明的方法，可以容易地观察到聚酯树脂/添加剂混合物的组成和均匀性，并且可以通过特征颜色和颜色变化来分别监视交联的进展。

公开(公告)号：US4522963A

公开(公告)日：1985-06-11

申请号：US541433

申请日：1983-10-13

申请人： Geza Kecskemethy ,  Istvan Kovacsay ,  Laszlo Magdanyi

发明人： Geza Kecskemethy ,  Istvan Kovacsay ,  Laszlo Magdanyi

IPC分类号： C08F299/04 ,  C08K5/00 ,  C08L67/06

CPC分类号： C08F299/0442 ,  C08K5/0041

摘要： The invention is a process for monitored cross-linking of unsaturated polyester resins in the presence of a metal-ion-containing accelerator and an organic peroxide initiator, complemented by promotor in some cases. According to this process, the cross-linking is carried out in the presence of one of the compounds from the group consisting of alizarin, sodium alizarinesulfonate, 3-nitroalizarin, chinizarine, or purpurin, where the substituents are H atoms or OH, NO.sub.2, SO.sub.3 H, or SO.sub.3 Na groups with the restriction that at least one of them should be other than H, which is present in a ratio of from 0.005 to 0.5, preferably 0.01 to 0.1 percent (mass/mass), compared to the mass of the polyester resin, and cross-linking is trailed by the color change in the system. The invention permits all of the chemical-technological processes involved in the processing of unsaturated polyester resins to be monitored visually.

摘要翻译： 本发明是在含有金属离子的促进剂和有机过氧化物引发剂的存在下，不稳定的不饱和聚酯树脂交联的方法，在一些情况下由促进剂补充。 根据该方法，在一种化合物的存在下进行交联，所述化合物来自茜素，茜素磺酸钠，3-硝基茜素，茜素或紫红素，其中取代基为H原子或OH，NO 2， SO 3 H或SO 3 Na基，其中至少一个不应该是H，与聚酯的质量相比，其比例为0.005至0.5，优选0.01至0.1％（质量/质量） 树脂和交联被系统中的颜色变化所拖累。 本发明允许所有涉及加工不饱和聚酯树脂的化学工艺过程被目视检测。