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1.发明申请Method of treatment of cardiac and/or renal failure using a calcium channel blocker and an angiotensin converting enzyme inhibitor or an angiotensin II receptor blocker 审中-公开使用钙通道阻滞剂和血管紧张素转换酶抑制剂或血管紧张素II受体阻断剂治疗心脏和/或肾衰竭的方法公开(公告)号：US20060058355A1
公开(公告)日：2006-03-16
申请号：US11209463
申请日：2005-08-23
申请人： Howard Dittrich , Lauren Otsuki , Kenneth Widder
发明人： Howard Dittrich , Lauren Otsuki , Kenneth Widder
IPC分类号： A61K31/455 , A61K31/4439
CPC分类号： A61K31/4164 , A61K31/401 , A61K31/44 , A61K31/4422 , A61K31/4439 , A61K31/455 , A61K45/06 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition comprising a calcium channel blocker and an angiotensin II receptor blocker or an angiotensin converting enzyme inhibitor. Also disclosed is a method of treating cardiovascular disease or renal disease comprising identifying a patient in need of such treatment, and administering a pharmaceutical composition disclosed herein to said patient.
摘要翻译： 公开了包含钙通道阻滞剂和血管紧张素II受体阻断剂或血管紧张素转化酶抑制剂的药物组合物。 还公开了治疗心血管疾病或肾脏疾病的方法，其包括鉴定需要这种治疗的患者，以及将本文公开的药物组合物给予所述患者。
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公开(公告)号：US20060035911A1
公开(公告)日：2006-02-16
申请号：US11248905
申请日：2005-10-11
申请人： Kenneth Widder , Lauren Otsuki , Howard Dittrich , Scott Thomson , Roland Blantz
发明人： Kenneth Widder , Lauren Otsuki , Howard Dittrich , Scott Thomson , Roland Blantz
IPC分类号： A61K31/549 , A61K31/522
CPC分类号： A61K45/06 , A61K31/405 , A61K31/522 , A61K31/63 , A61K31/635 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition comprising a therapeutically effective amount of KW-3902, or a salt, ester, amide, metabolite, or prodrug thereof, and a non-adenosine modifying diuretic. Also disclosed are methods of inducing a diuretic effect in an animal comprising the step of administering a therapeutically effective amount of KW-3902, or a salt, ester, amide, metabolite, or prodrug thereof, in combination with second pharmaceutical composition capable of inducing a diuretic effect.
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公开(公告)号：US20050004145A1
公开(公告)日：2005-01-06
申请号：US10830617
申请日：2004-04-23
申请人： Kenneth Widder , Lauren Otsuki , Howard Dittrich , Scott Thomson , Roland Blantz
发明人： Kenneth Widder , Lauren Otsuki , Howard Dittrich , Scott Thomson , Roland Blantz
IPC分类号： A61K31/405 , A61K31/522 , A61K31/63 , A61K31/635 , A61K45/06 , A61P7/10
CPC分类号： A61K45/06 , A61K31/405 , A61K31/522 , A61K31/63 , A61K31/635 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition comprising a therapeutically effective amount of KW-3902, or a salt, ester, amide, metabolite, or prodrug thereof, and a non-adenosine modifying diuretic. Also disclosed are methods of inducing a diuretic effect in an animal comprising the step of administering a therapeutically effective amount of KW-3902, or a salt, ester, amide, metabolite, or prodrug thereof, in combination with second pharmaceutical composition capable of inducing a diuretic effect.
摘要翻译： 公开了包含治疗有效量的KW-3902或其盐，酯，酰胺，代谢物或前药以及非腺苷改性利尿剂的药物组合物。 还公开了在动物中诱导利尿作用的方法，包括施用治疗有效量的KW-3902或其盐，酯，酰胺，代谢物或前药与能够诱导 利尿作用。
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公开(公告)号：US20060030572A1
公开(公告)日：2006-02-09
申请号：US11248479
申请日：2005-10-11
申请人： Kenneth Widder , Lauren Otsuki , Howard Dittrich , Scott Thomson , Roland Blantz
发明人： Kenneth Widder , Lauren Otsuki , Howard Dittrich , Scott Thomson , Roland Blantz
IPC分类号： A61K31/549 , A61K31/522
CPC分类号： A61K45/06 , A61K31/405 , A61K31/522 , A61K31/63 , A61K31/635 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition comprising a therapeutically effective amount of KW-3902, or a salt, ester, amide, metabolite, or prodrug thereof, and a non-adenosine modifying diuretic. Also disclosed are methods of inducing a diuretic effect in an animal comprising the step of administering a therapeutically effective amount of KW-3902, or a salt, ester, amide, metabolite, or prodrug thereof, in combination with second pharmaceutical composition capable of inducing a diuretic effect.
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5.发明申请Method of treatment of disease using an adenosine A1 receptor antagonist and an aldosterone inhibitor 审中-公开使用腺苷A1受体拮抗剂和醛固酮抑制剂治疗疾病的方法公开(公告)号：US20050239759A1
公开(公告)日：2005-10-27
申请号：US11107637
申请日：2005-04-14
申请人： Lauren Otsuki , Kenneth Widder , Howard Dittrich
发明人： Lauren Otsuki , Kenneth Widder , Howard Dittrich
IPC分类号： A61K31/437 , A61K31/4745 , A61K31/522 , A61K31/56 , A61K31/585 , A61K45/06
CPC分类号： A61K31/437 , A61K31/4745 , A61K31/522 , A61K31/56 , A61K31/585 , A61K45/06 , A61K2300/00
摘要： Pharmaceutical compositions comprising an aldosterone inhibitor and an adenosine A1 receptor antagonist (AA1RA) and methods of treating cardiovascular disease comprising identifying a patient in need of such treatment, and administering a pharmaceutical composition disclosed herein to said patient are disclosed.
摘要翻译： 包含醛固酮抑制剂和腺苷A 1受体拮抗剂（AA 1 RA）的药物组合物和治疗心血管疾病的方法包括鉴定需要这种治疗的患者，以及施用 公开了向所述患者公开的药物组合物。
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6.发明申请METHOD OF TREATMENT OF DISEASE USING AN ADENOSINE A1 RECEPTOR ANTAGONIST AND AN ALDOSTERONE INHIBITOR 审中-公开使用腺苷A1受体拮抗剂和阿尔托斯酮抑制剂治疗疾病的方法公开(公告)号：US20090253665A1
公开(公告)日：2009-10-08
申请号：US12485797
申请日：2009-06-16
IPC分类号： A61K31/585 , A61K31/522 , A61P9/00 , A61P13/12 , A61P9/04 , A61P9/12 , A61P9/10
CPC分类号： A61K31/437 , A61K31/4745 , A61K31/522 , A61K31/56 , A61K31/585 , A61K45/06 , A61K2300/00
摘要： Pharmaceutical compositions comprising an aldosterone inhibitor and an adenosine A1 receptor antagonist (AA1RA) and methods of treating cardiovascular disease comprising identifying a patient in need of such treatment, and administering a pharmaceutical composition disclosed herein to said patient are disclosed.
摘要翻译： 公开了包含醛固酮抑制剂和腺苷A1受体拮抗剂（AA1RA）的药物组合物和治疗心血管疾病的方法，包括鉴定需要这种治疗的患者，以及向所述患者施用本文公开的药物组合物。
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公开(公告)号：US07579331B2
公开(公告)日：2009-08-25
申请号：US10830617
申请日：2004-04-23
IPC分类号： A61K31/70
CPC分类号： A61K45/06 , A61K31/405 , A61K31/522 , A61K31/63 , A61K31/635 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition comprising a therapeutically effective amount of KW-3902, or a salt, ester, amide, metabolite, or prodrug thereof, and a non-adenosine modifying diuretic. Also disclosed are methods of inducing a diuretic effect in an animal comprising the step of administering a therapeutically effective amount of KW-3902, or a salt, ester, amide, metabolite, or prodrug thereof, in combination with second pharmaceutical composition capable of inducing a diuretic effect.
摘要翻译： 公开了包含治疗有效量的KW-3902或其盐，酯，酰胺，代谢物或前药以及非腺苷改性利尿剂的药物组合物。 还公开了在动物中诱导利尿作用的方法，包括施用治疗有效量的KW-3902或其盐，酯，酰胺，代谢物或前药与能够诱导 利尿作用。
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8.发明申请METHOD OF TREATMENT OF CARDIAC AND/OR RENAL FAILURE USING A CALCIUM CHANNEL BLOCKER AND AN ANGIOTENSIN CONVERTING ENZYME INHIBITOR OR AN ANGIOTENSIN II RECEPTOR BLOCKER 审中-公开使用钙通道阻断剂和转化酶抑制剂或ANGIOTENSIN II受体阻断剂治疗心脏病和/或肾功能衰竭的方法公开(公告)号：US20090118334A1
公开(公告)日：2009-05-07
申请号：US12351728
申请日：2009-01-09
IPC分类号： A61K31/4439 , A61K31/44 , A61P9/00
CPC分类号： A61K31/4164 , A61K31/401 , A61K31/44 , A61K31/4422 , A61K31/4439 , A61K31/455 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical composition including a calcium channel blocker and an angiotensin II receptor blocker or an angiotensin converting enzyme inhibitor. Also disclosed is a method of treating cardiovascular disease or renal disease by identifying a patient in need of such treatment, and administering a pharmaceutical composition disclosed herein to said patient.
摘要翻译： 一种药物组合物，其包含钙通道阻滞剂和血管紧张素II受体阻断剂或血管紧张素转换酶抑制剂。 还公开了通过鉴定需要这种治疗的患者并将所述药物组合物给予所述患者来治疗心血管疾病或肾脏疾病的方法。
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