公开(公告)号：US08552018B2

公开(公告)日：2013-10-08

申请号：US13051790

申请日：2011-03-18

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Steven L. Warner ,  James Welsh

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Steven L. Warner ,  James Welsh

IPC分类号： A61K31/519 ,  A61K31/496 ,  A61P35/04 ,  C07D491/14 ,  C07D471/14 ,  C07D239/70 ,  A61K31/517

CPC分类号： A61K31/519 ,  A61K45/06 ,  A61N5/00 ,  C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

摘要翻译： 公开了可用于治疗蛋白激酶介导的疾病和病症（例如癌症）的蛋白激酶抑制剂。 本发明化合物具有以下结构：包括立体异构体，前体药物和药学上可接受的盐，其中A是选自以下的环部分：其中R1，R2，R3，X，Z，L1，Cyc11，L2和Cyc22为 本文定义。 还公开了含有本发明化合物的组合物以及与其用途有关的方法。

公开(公告)号：US20090099165A1

公开(公告)日：2009-04-16

申请号：US11735344

申请日：2007-04-13

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

IPC分类号： A61K31/5377 ,  C07D487/04 ,  A61K31/519

CPC分类号： A61K31/519 ,  A61K45/06 ,  A61N5/00 ,  C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

公开(公告)号：US20110212929A1

公开(公告)日：2011-09-01

申请号：US13051790

申请日：2011-03-18

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

IPC分类号： A61K31/635 ,  C07D487/04 ,  A61K31/496 ,  C07D471/14 ,  A61K31/519 ,  C07D413/14 ,  A61K31/5377 ,  A61P35/00

CPC分类号： A61K31/519 ,  A61K45/06 ,  A61N5/00 ,  C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

摘要翻译： 公开了可用于治疗蛋白激酶介导的疾病和病症（例如癌症）的蛋白激酶抑制剂。 本发明化合物具有以下结构：包括立体异构体，前体药物和药学上可接受的盐，其中A是选自以下的环部分：其中R1，R2，R3，X，Z，L1，Cyc11，L2和Cyc22为 本文定义。 还公开了含有本发明化合物的组合物以及与其用途有关的方法。

公开(公告)号：US20090143399A1

公开(公告)日：2009-06-04

申请号：US11841574

申请日：2007-08-20

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

IPC分类号： A61K31/496 ,  C07D487/04 ,  C07D495/14 ,  C07D491/048 ,  A61P35/04

CPC分类号： C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

摘要翻译： 公开了可用于治疗蛋白激酶介导的疾病和病症（例如癌症）的蛋白激酶抑制剂。 本发明化合物具有以下结构：包括立体异构体，前体药物和药学上可接受的盐，其中A是选自以下的环部分：其中R1，R2，R3，X，Z，L1，Cyc11，L2和Cyc22为 本文定义。 还公开了含有本发明化合物的组合物以及与其用途有关的方法。

公开(公告)号：US20130302303A1

公开(公告)日：2013-11-14

申请号：US13947691

申请日：2013-07-22

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Steven L. Warner ,  James Welsh

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Steven L. Warner ,  James Welsh

IPC分类号： A61K31/519 ,  A61K45/06 ,  A61N5/00 ,  C07D491/048

CPC分类号： A61K31/519 ,  A61K45/06 ,  A61N5/00 ,  C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

摘要翻译： 公开了可用于治疗蛋白激酶介导的疾病和病症（例如癌症）的蛋白激酶抑制剂。 本发明化合物具有以下结构：包括立体异构体，前体药物和药学上可接受的盐，其中A是选自以下的环部分：其中R1，R2，R3，X，Z，L1，Cyc11，L2和Cyc22为 本文定义。 还公开了含有本发明化合物的组合物以及与其用途有关的方法。

公开(公告)号：US20080051414A1

公开(公告)日：2008-02-28

申请号：US11680921

申请日：2007-03-01

申请人： Laurence Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben Munoz ,  Steven Warner ,  Kimiko Della Croce ,  Daniel Von Hoff ,  Cory Grand ,  James Welsh

发明人： Laurence Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben Munoz ,  Steven Warner ,  Kimiko Della Croce ,  Daniel Von Hoff ,  Cory Grand ,  James Welsh

IPC分类号： A61K31/496 ,  A61P35/00 ,  A61P43/00 ,  C07D241/04 ,  C07D401/14 ,  C07D403/02 ,  C07D471/04

CPC分类号： C07D487/04 ,  C07D403/14 ,  C07D405/14 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

摘要翻译： 公开了可用于治疗蛋白激酶介导的疾病和病症（例如癌症）的蛋白激酶抑制剂。 本发明的化合物具有以下结构：包括立体异构体，其前药和药学上可接受的盐，其中A是选自以下的环部分：其中R 1，R 2，R 3，X，Z，L 1，Cyc 11， L 2和Cyc 2如本文所定义。 还公开了含有本发明化合物的组合物以及与其用途有关的方法。

公开(公告)号：US20100140845A1

公开(公告)日：2010-06-10

申请号：US12331618

申请日：2008-12-10

申请人： James Welsh ,  Graham Goodge

发明人： James Welsh ,  Graham Goodge

IPC分类号： B29C45/00

CPC分类号： B29C45/2673 ,  B29C45/1742 ,  B29C45/2675

摘要： A modular mold system includes a hot half and a cold half. The hot half has a heated distributor assembly to receive molding material from an injection molding machine. The distributor assembly has a forward side that is opposite a side of the distributor assembly that faces the injection molding machine. A plurality of heated multi-nozzle units may also be provided. Each multi-nozzle unit has a manifold and a plurality of forward-extending nozzles. Each multi-nozzle unit is individually forwardly removably fastened to the forward side of the distributor assembly and removable from the distributor assembly while the distributor assembly is fastened to the first platen. The cold half includes a mounting plate and a plurality of cold-side units associated with the multi-nozzle units. Each cold-side unit is removably fastened to the mounting plate and engagable with one of the multi-nozzle units to define the one or more mold cavities.

摘要翻译： 模块化模具系统包括热半部和冷半部。 热的一半具有加热的分配器组件以从注射成型机接收成型材料。 分配器组件具有与分配器组件的面向注射成型机的一侧相对的前侧。 还可以设置多个加热的多喷嘴单元。 每个多喷嘴单元具有歧管和多个向前延伸的喷嘴。 每个多喷嘴单元分别向前可拆卸地紧固到分配器组件的前侧并且可以在分配器组件紧固到第一压板时从分配器组件移除。 冷的一半包括安装板和与多个喷嘴单元相关联的多个冷侧单元。 每个冷侧单元可拆卸地紧固到安装板并且可与多个喷嘴单元中的一个接合以限定一个或多个模腔。

公开(公告)号：US07069929B2

公开(公告)日：2006-07-04

申请号：US10099592

申请日：2002-03-15

申请人： Matthew Young ,  Stuart Kay ,  Neil Harrison ,  James Welsh ,  Michael Ligotke

发明人： Matthew Young ,  Stuart Kay ,  Neil Harrison ,  James Welsh ,  Michael Ligotke

IPC分类号： A61M15/00 ,  B65D83/06

CPC分类号： A61M15/0086 ,  A61M15/0008 ,  A61M15/0026 ,  A61M15/0031 ,  A61M15/0043 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0071 ,  A61M15/0075 ,  A61M15/02 ,  A61M2202/064 ,  A61M2205/583 ,  A61M2205/6045 ,  A61M2206/16

摘要： A dry powder inhaler includes an actuator pivotably mounted on a base. Movement of the actuator from a first position to a second position drives the a dobber to open a blister. A dispersion engine sub-assembly has a blister hood positioned over a blister opening position. A powder pathway connects from the blister hood into a powder dispersion engine. Upon inhalation, air flow draws powder up and out of an opened blister, into the blister hood and to the powder dispersion engine. Movement of the actuator causes the dobber to shear open a blister and also to press the blister hood down over the blister. This increases air flows up and around the open blister, carrying the pharmaceutical powder up and out of the blister and into the dispersion engine.

摘要翻译： 干粉吸入器包括可枢转地安装在基座上的致动器。 致动器从第一位置到第二位置的移动驱动一个阻挡器以打开水泡。 分散发动机子组件具有位于泡罩打开位置上方的泡罩罩。 粉末通道从泡罩罩连接成粉末分散发动机。 吸入后，空气流将粉末从开放的水泡中抽出，进入泡罩罩和粉末分散发动机。 执行机构的运动导致踩踏器打开水泡并且还将泡罩罩向下压过水泡。 这增加了空气在开放的水泡周围流动，并将药剂粉末从泡罩中提出并进入分散发动机。

公开(公告)号：US07815840B2

公开(公告)日：2010-10-19

申请号：US12331618

申请日：2008-12-10

申请人： James Welsh ,  Graham Goodge

发明人： James Welsh ,  Graham Goodge

IPC分类号： B29C45/26

CPC分类号： B29C45/2673 ,  B29C45/1742 ,  B29C45/2675

摘要： A modular mold system includes a hot half and a cold half. The hot half has a heated distributor assembly to receive molding material from an injection molding machine. The distributor assembly has a forward side that is opposite a side of the distributor assembly that faces the injection molding machine. A plurality of heated multi-nozzle units may also be provided. Each multi-nozzle unit has a manifold and a plurality of forward-extending nozzles. Each multi-nozzle unit is individually forwardly removably fastened to the forward side of the distributor assembly and removable from the distributor assembly while the distributor assembly is fastened to the first platen. The cold half includes a mounting plate and a plurality of cold-side units associated with the multi-nozzle units. Each cold-side unit is removably fastened to the mounting plate and engagable with one of the multi-nozzle units to define the one or more mold cavities.

摘要翻译： 模块化模具系统包括热半部和冷半部。 热的一半具有加热的分配器组件以从注射成型机接收成型材料。 分配器组件具有与分配器组件的面向注射成型机的一侧相对的前侧。 还可以设置多个加热的多喷嘴单元。 每个多喷嘴单元具有歧管和多个向前延伸的喷嘴。 每个多喷嘴单元分别向前可拆卸地紧固到分配器组件的前侧并且可以在分配器组件紧固到第一压板时从分配器组件移除。 冷的一半包括安装板和与多个喷嘴单元相关联的多个冷侧单元。 每个冷侧单元可拆卸地紧固到安装板并且可与多个喷嘴单元中的一个接合以限定一个或多个模腔。