Leishmania Challenge Model
    1.
    发明申请
    Leishmania Challenge Model 有权
    利什曼样式挑战模式

    公开(公告)号:US20130219530A1

    公开(公告)日:2013-08-22

    申请号:US13841949

    申请日:2013-03-15

    IPC分类号: A01K67/027

    摘要: The present invention provides a method for effectively and reproducibly infecting canines with Leishmania infantum using sand flies to vector the parasite. The inventive method comprises several steps, including ensuring canines are naïve to Leishmania, infecting the canines using bites of Leishmania-infected sand fly bites, and evaluating successful transmission of the Leishmania parasites.

    摘要翻译: 本发明提供了一种利用沙蝇来有效地和可重复地感染利什曼原虫的狗的方法,以传播寄生虫。 本发明的方法包括几个步骤,包括确保犬只对利什曼原住地幼稚,利用利什曼原虫感染的沙蝇咬伤的叮咬感染犬只,并评估利什曼原虫寄生虫的成功传播。

    Truncated transcriptionally active cytomegalovirus promoters
    9.
    发明授权
    Truncated transcriptionally active cytomegalovirus promoters 失效
    截短的转录活性巨细胞病毒启动子

    公开(公告)号:US6156567A

    公开(公告)日:2000-12-05

    申请号:US675556

    申请日:1996-07-03

    申请人: Laurent Fischer

    发明人: Laurent Fischer

    摘要: Recombinant adenoviruses, methods of making them, uses for them, including in immunological, immunogenic, vaccine or therapeutic compositions, or, as a vector for cloning, replicating or expressing DNA and methods of using the compositions and vector, expression products from them, and uses for the expression products are provided. More particularly, recombinant canine adenoviruses (CAV) and methods of making them, uses for them, expression products from them, and uses for the expression products, including recombinant CAV2 viruses are provided. Additionally, truncated promoters, expression cassettes containing the promoters, and recombinant viruses and plasmids containing the promoters or expression cassettes are provided.

    摘要翻译: 重组腺病毒及其制备方法,包括免疫学,免疫原性,疫苗或治疗组合物,或作为克隆,复制或表达DNA的载体和使用组合物和载体的方法,从其中表达产物,以及 提供表达产品的用途。 更具体地,提供了重组犬腺病毒(CAV)及其制备方法,用于它们,表达产物,以及用于表达产物,包括重组CAV2病毒的用途。 此外,提供了截短的启动子,含有启动子的表达盒,以及含有启动子或表达盒的重组病毒和质粒。