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公开(公告)号：US06992102B2
公开(公告)日：2006-01-31
申请号：US10685020
申请日：2003-10-14
申请人： Lawrence Hamann , David Augeri , Chongqing Sun , Jeffrey A. Robl , Mark E. Salvati , Tammy Wang
发明人： Lawrence Hamann , David Augeri , Chongqing Sun , Jeffrey A. Robl , Mark E. Salvati , Tammy Wang
IPC分类号： A61K31/40 , C07D207/00
CPC分类号： C07D207/16 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The invention provides compounds of the formula I wherein the substitutents are as described herein.Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia, and also provided are pharmaceutical compositions containing such compounds.
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公开(公告)号：US06670386B2
公开(公告)日：2003-12-30
申请号：US10209461
申请日：2002-07-31
申请人： Chongqing Sun , Jeffrey A. Robl , Mark E. Salvati , Tammy Wang , Lawrence Hamann , David Augeri
发明人： Chongqing Sun , Jeffrey A. Robl , Mark E. Salvati , Tammy Wang , Lawrence Hamann , David Augeri
IPC分类号： A01K4352
CPC分类号： C07D207/16 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The invention provides compounds of the formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia, and also provided are pharmaceutical compositions containing such compounds.
摘要翻译： 本发明提供式I化合物，其中取代基如本文所述。进一步提供的是使用这些化合物治疗核激素受体相关病症（例如年龄相关疾病，例如肌肉减少症）的方法，并且还提供药物组合物 含有这些化合物。
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公开(公告)号：US20080108649A1
公开(公告)日：2008-05-08
申请号：US11931282
申请日：2007-10-31
申请人： Chong-Qing Sun , Lawrence Hamann , David Augeri , Yingzhi Bi , Jeffrey Robl , Yan-Ting Huang , Tammy Wang , Alexandra Holubec , Ligaya Simpkins , James Sutton , James Li
发明人： Chong-Qing Sun , Lawrence Hamann , David Augeri , Yingzhi Bi , Jeffrey Robl , Yan-Ting Huang , Tammy Wang , Alexandra Holubec , Ligaya Simpkins , James Sutton , James Li
IPC分类号： A61K31/4545 , A61K31/4164 , A61K31/47 , A61P21/00 , C07D217/00 , C07D235/00 , C07D471/02
CPC分类号： C07D487/04 , C07D471/04
摘要： There are provided compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention. Other embodiments are also disclosed.
摘要翻译： 提供根据式I的化合物，其中取代基如本文所述。 进一步提供的是使用这些化合物来治疗核激素受体相关病症的方法，例如年龄相关疾病，例如肌肉减少症。 还提供了含有这些化合物的药物组合物和制备本发明的一些化合物的方法。 还公开了其他实施例。
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公开(公告)号：US07772267B2
公开(公告)日：2010-08-10
申请号：US11931282
申请日：2007-10-31
申请人： Chong-qing Sun , Lawrence Hamann , David Augeri , Yingzhi Bi , Jeffrey Robl , Yan-Ting Huang , Tammy Wang , Alexandra Holubec , Ligaya Simpkins , James C. Sutton , James J. Li
发明人： Chong-qing Sun , Lawrence Hamann , David Augeri , Yingzhi Bi , Jeffrey Robl , Yan-Ting Huang , Tammy Wang , Alexandra Holubec , Ligaya Simpkins , James C. Sutton , James J. Li
IPC分类号： A61K31/415 , C07D235/02
CPC分类号： C07D487/04 , C07D471/04
摘要： There are provided compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention. Other embodiments are also disclosed.
摘要翻译： 提供根据式I的化合物，其中取代基如本文所述。 进一步提供的是使用这些化合物来治疗核激素受体相关病症的方法，例如年龄相关疾病，例如肌肉减少症。 还提供了含有这些化合物的药物组合物和制备本发明的一些化合物的方法。 还公开了其他实施例。
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公开(公告)号：US07405234B2
公开(公告)日：2008-07-29
申请号：US10780415
申请日：2004-02-17
申请人： Chong-Qing Sun , Lawrence Hamann , David Augeri , Yingzhi Bi , Jeffrey Robl , Yan-Ting Huang , Tammy Wang , Alexandra Holubec , Ligaya Simpkins , James C. Sutton , James J. Li
发明人： Chong-Qing Sun , Lawrence Hamann , David Augeri , Yingzhi Bi , Jeffrey Robl , Yan-Ting Huang , Tammy Wang , Alexandra Holubec , Ligaya Simpkins , James C. Sutton , James J. Li
IPC分类号： A61K31/415 , C07D235/02
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention provides compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.
摘要翻译： 本发明提供式I化合物，其中取代基如本文所述。 进一步提供的是使用这些化合物来治疗核激素受体相关病症的方法，例如年龄相关疾病，例如肌肉减少症。 还提供了含有这些化合物的药物组合物和制备本发明的一些化合物的方法。
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公开(公告)号：US07625923B2
公开(公告)日：2009-12-01
申请号：US11070808
申请日：2005-03-02
申请人： Alexandra Nirschl , James C. Sutton , Lawrence Hamann , Tammy Wang , Yan Zou , Chongqing Sun
发明人： Alexandra Nirschl , James C. Sutton , Lawrence Hamann , Tammy Wang , Yan Zou , Chongqing Sun
IPC分类号： A61K31/4745 , C07D491/02
CPC分类号： C07D487/04 , C07D498/04 , C07D513/04
摘要： The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia, wherein R1, R2, R5, X, Y and n are defined herein.
摘要翻译： 本发明涉及式I的双环化合物，含有这些化合物的药物组合物和使用这些化合物治疗雄激素受体相关病症如年龄相关疾病，例如肌肉减少症的方法，其中R1，R2，R5 ，X，Y和n如本文所定义。
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公开(公告)号：US20050197359A1
公开(公告)日：2005-09-08
申请号：US11070808
申请日：2005-03-02
申请人： Alexandra Nirschl , James Sutton , Lawrence Hamann , Tammy Wang , Yan Zou , Chongqing Sun
发明人： Alexandra Nirschl , James Sutton , Lawrence Hamann , Tammy Wang , Yan Zou , Chongqing Sun
IPC分类号： A61K31/424 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4745 , C07D263/60 , C07D471/02 , C07D491/02 , C07D498/02
CPC分类号： C07D487/04 , C07D498/04 , C07D513/04
摘要： The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia, wherein R1, R2, R5, X, Y and n are defined herein.
摘要翻译： 本发明涉及式I的双环化合物，含有这些化合物的药物组合物和使用这些化合物治疗雄激素受体相关病症例如年龄相关疾病，例如肌肉减少症的方法，其中R 1 R 2，R 5，X，Y和n在本文中定义。
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8.发明授权Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions 有权P2Y1受体的尿素拮抗剂可用于治疗血栓形成公开(公告)号：US07388021B2
公开(公告)日：2008-06-17
申请号：US11126915
申请日：2005-05-10
申请人： Hannguang J. Chao , Huji Tuerdi , Timothy F. Herpin , Jacques Yves Roberge , Yalei Liu , R. Michael Lawrence , Robert P. Rehfuss , Charles G. Clark , Jennifer X. Qiao , Timur Gungor , Patrick Y. S. Lam , Tammy Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora M. Schnur
发明人： Hannguang J. Chao , Huji Tuerdi , Timothy F. Herpin , Jacques Yves Roberge , Yalei Liu , R. Michael Lawrence , Robert P. Rehfuss , Charles G. Clark , Jennifer X. Qiao , Timur Gungor , Patrick Y. S. Lam , Tammy Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora M. Schnur
IPC分类号： A61K31/4412 , A61K31/444 , C07D213/60 , C07D213/72
CPC分类号： C07D409/14 , C07C275/30 , C07C275/32 , C07D213/40 , C07D213/75 , C07D213/89 , C07D231/40 , C07D231/50 , C07D237/22 , C07D333/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07F7/1804
摘要： The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译： 本发明提供了新的吡啶基或苯基脲及其类似物，它们是人P2Y 1受体的选择性抑制剂。 本发明还提供了相同的各种药物组合物以及治疗对P2Y受体活性的调节作用的疾病的方法。
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公开(公告)号：US20070161685A1
公开(公告)日：2007-07-12
申请号：US11559930
申请日：2006-11-15
申请人： Mark Salvati , Heather Finlay , Lalgudi Harikrishnan , Ji Jiang , James Johnson , Muthoni Kamau , R. Lawrence , Michael Miller , Jennifer Qiao , Tammy Wang , Yufeng Wang , Wu Yang
发明人： Mark Salvati , Heather Finlay , Lalgudi Harikrishnan , Ji Jiang , James Johnson , Muthoni Kamau , R. Lawrence , Michael Miller , Jennifer Qiao , Tammy Wang , Yufeng Wang , Wu Yang
IPC分类号： A61K31/44 , C07D213/56
CPC分类号： C07D417/06 , C07D213/40 , C07D213/61 , C07D277/28 , C07D401/04 , C07D401/12 , C07D405/06 , C07D405/12 , C07D417/12
摘要： Compounds of formula Ia and Ib wherein A, B, C and R1 are described herein.
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公开(公告)号：US08647254B2
公开(公告)日：2014-02-11
申请号：US12166247
申请日：2008-07-01
申请人： Peter Tachi Callas , Pierluca Lombardi , Michael C. Stewart , Liming Lau , Mark S. Juravic , Evan Anderson , Joe Lamberti , Albert K. Chin , Tammy Wang
发明人： Peter Tachi Callas , Pierluca Lombardi , Michael C. Stewart , Liming Lau , Mark S. Juravic , Evan Anderson , Joe Lamberti , Albert K. Chin , Tammy Wang
CPC分类号： A61F2/2451 , A61F2/2442 , A61F2/2478 , A61F2/2481 , A61F2/2496
摘要： An epicardial clip for reshaping the annulus of the mitral valve of a heart. The epicardial clip includes a curved member having an anterior segment configured to be positioned in the transverse sinus of the heart, a posterior segment configured to be positioned on the posterior side of the heart, such as on or inferior to the atrioventricular groove, and a lateral segment extending between the anterior segment and the posterior segment. The lateral segment includes a curve such that the first end of the member is positioned at or above the plane of the mitral valve and the second end of the member is positioned at or below the plane of the mitral valve.
摘要翻译： 用于重塑心脏二尖瓣环的心外膜。 心外膜包括弯曲构件，其具有被构造成定位在心脏的横向窦内的前部区段，构造成位于心脏后侧（例如在房室下方或下方）的后部区段，以及 侧段在前段和后段之间延伸。 横向段包括曲线，使得构件的第一端定位在二尖瓣的平面上或上方，并且构件的第二端位于二尖瓣的平面处或下方。
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