公开(公告)号：US5850086A

公开(公告)日：1998-12-15

申请号：US670794

申请日：1996-06-21

申请人： Lawrence Que, Jr. ,  Cheal Kim ,  Jinheung Kim ,  Yan Zang

发明人： Lawrence Que, Jr. ,  Cheal Kim ,  Jinheung Kim ,  Yan Zang

IPC分类号： B01J31/18 ,  C07C29/48 ,  C07C45/28 ,  C07D303/04 ,  C07F15/02 ,  C11D3/39 ,  C07B33/00

CPC分类号： C11D3/3932 ,  B01J31/1815 ,  C07C29/48 ,  C07C45/28 ,  C07D303/04 ,  C07F15/025 ,  B01J2531/842 ,  C07B2200/09 ,  C07C2101/14 ,  C07C2101/16 ,  C07C2101/18

摘要： A bleach and oxidation catalyst is provided comprising a catalytically active iron complex which can activate hydrogen peroxide or peroxy acids, for example.

公开(公告)号：US6107528A

公开(公告)日：2000-08-22

申请号：US204132

申请日：1998-12-02

申请人： Lawrence Que, Jr. ,  Cheal Kim ,  Jinheung Kim ,  Yan Zang

发明人： Lawrence Que, Jr. ,  Cheal Kim ,  Jinheung Kim ,  Yan Zang

IPC分类号： B01J31/18 ,  C07C29/48 ,  C07C45/28 ,  C07D303/04 ,  C07F15/02 ,  C11D3/39 ,  C07C35/08 ,  A01N3/00 ,  C07F15/00 ,  C11D3/00

CPC分类号： C11D3/3932 ,  B01J31/1815 ,  C07C29/48 ,  C07C45/28 ,  C07D303/04 ,  C07F15/025 ,  B01J2531/842 ,  C07B2200/09 ,  C07C2101/14 ,  C07C2101/16 ,  C07C2101/18

摘要： A bleach and oxidation catalyst is provided comprising a catalytically active iron complex which can activate hydrogen peroxide or peroxy acids, for example.

摘要翻译： 提供了一种漂白和氧化催化剂，其包括例如可活化过氧化氢或过氧酸的催化活性铁络合物。

公开(公告)号：US5871918A

公开(公告)日：1999-02-16

申请号：US667338

申请日：1996-06-20

申请人： H. Holden Thorp ,  Dean H. Johnston ,  Mary E. Napier ,  Carson R. Loomis ,  Mark F. Sistare ,  Jinheung Kim

发明人： H. Holden Thorp ,  Dean H. Johnston ,  Mary E. Napier ,  Carson R. Loomis ,  Mark F. Sistare ,  Jinheung Kim

IPC分类号： C12P19/34 ,  C12Q1/68

CPC分类号： B82Y30/00 ,  B82Y15/00 ,  C12Q1/6816 ,  C12Q1/6825

摘要： A method of detecting a nucleic acid (e.g., DNA, RNA) that contains at least one preselected base (e.g., adenine, guanine, 6-mercaptoguanine, 8-oxo-guanine, and 8-oxo-adenine) comprises (a) reacting the nucleic acid with a transition metal complex capable of oxidizing the preselected base in an oxidation-reduction reaction; (b) detecting the oxidation-reduction reaction; and (c) determining the presence or absence of the nucleic acid from the detected oxidation-reduction reaction at the preselected base. The method may be used in a variety of applications, including DNA sequencing, diagnostic assays, and quantitative analysis.

公开(公告)号：US6132971A

公开(公告)日：2000-10-17

申请号：US179665

申请日：1998-10-27

申请人： H. Holden Thorp ,  Dean H. Johnston ,  Mary E. Napier ,  Carson R. Loomis ,  Mark F. Sistare ,  Jinheung Kim

发明人： H. Holden Thorp ,  Dean H. Johnston ,  Mary E. Napier ,  Carson R. Loomis ,  Mark F. Sistare ,  Jinheung Kim

摘要： A method of detecting a nucleic acid (e.g., DNA, RNA) that contains at least one preselected base (e.g., adenine, guanine, 6-mercaptoguanine, 8-oxo-guanine, and 8-oxo-adenine) comprises (a) reacting the nucleic acid with a transition metal complex capable of oxidizing the preselected base in an oxidation-reduction reaction; (b) detecting the oxidation-reduction reaction; and (c) determining the presence or absence of the nucleic acid from the detected oxidation-reduction reaction at the preselected base. The method may be used in a variety of applications, including DNA sequencing, diagnostic assays, and quantitative analysis.

公开(公告)号：US06361951B1

公开(公告)日：2002-03-26

申请号：US09603217

申请日：2000-06-26

申请人： H. Holden Thorp ,  Dean H. Johnston ,  Mary E. Napier ,  Carson R. Loomis ,  Mark F. Sistare ,  Jinheung Kim

发明人： H. Holden Thorp ,  Dean H. Johnston ,  Mary E. Napier ,  Carson R. Loomis ,  Mark F. Sistare ,  Jinheung Kim

IPC分类号： C12Q168

CPC分类号： B82Y30/00 ,  B82Y15/00 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6869 ,  C12Q2600/156 ,  C12Q2563/113 ,  C12Q2525/197 ,  C12Q2525/117

摘要： A method of detecting a nucleic acid (e.g., DNA, RNA) that contains at least one preselected base (e.g., adenine, guanine, 6-mercaptoguanine, 8-oxo-guanine, and 8-oxo-adenine) comprises (a) reacting the nucleic acid with a transition metal complex capable of oxidizing the preselected base in an oxidation-reduction reaction; (b) detecting the oxidation-reduction reaction; and (c) determining the presence or absence of the nucleic acid from the detected oxidation-reduction reaction at the preselected base. The method may be used in a variety of applications, including DNA sequencing, diagnostic assays, and quantitative analysis.

公开(公告)号：US20050233358A1

公开(公告)日：2005-10-20

申请号：US11072388

申请日：2005-03-04

申请人： H. Thorp ,  Dean Johnston ,  Mary Napier ,  Carson Loomis ,  Mark Sistare ,  Jinheung Kim

发明人： H. Thorp ,  Dean Johnston ,  Mary Napier ,  Carson Loomis ,  Mark Sistare ,  Jinheung Kim

IPC分类号： C12Q1/68

CPC分类号： B82Y30/00 ,  B82Y15/00 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6869 ,  C12Q2600/156 ,  C12Q2563/113 ,  C12Q2525/197 ,  C12Q2525/117

摘要： A method of detecting a nucleic acid (e.g., DNA, RNA) that contains at least one preselected base (e.g., adenine, guanine, 6-mercaptoguanine, 8-oxo-guanine, and 8-oxo-adenine) comprises (a) reacting the nucleic acid with a transition metal complex capable of oxidizing the preselected base in an oxidation-reduction reaction; (b) detecting the oxidation-reduction reaction; and (c) determining the presence or absence of the nucleic acid from the detected oxidation-reduction reaction at the preselected base. The method may be used in a variety of applications, including DNA sequencing, diagnostic assays, and quantitative analysis.

摘要翻译： 检测含有至少一个预选碱基（例如腺嘌呤，鸟嘌呤，6-巯基鸟嘌呤，8-氧代鸟嘌呤和8-氧代腺嘌呤）的核酸（例如DNA，RNA）的方法包括：（a）使 具有能够在氧化还原反应中氧化预选碱的过渡金属络合物的核酸; （b）检测氧化还原反应; 和（c）从预选碱基处检测到的氧化还原反应确定核酸的存在或不存在。 该方法可用于多种应用，包括DNA测序，诊断测定和定量分析。

公开(公告)号：US07049068B2

公开(公告)日：2006-05-23

申请号：US10008233

申请日：2001-11-06

申请人： H. Holden Thorp ,  Dean H. Johnston ,  Mary E. Napier ,  Carson R. Loomis ,  Mark F. Sistare ,  Jinheung Kim

发明人： H. Holden Thorp ,  Dean H. Johnston ,  Mary E. Napier ,  Carson R. Loomis ,  Mark F. Sistare ,  Jinheung Kim

IPC分类号： C12Q1/68 ,  C12M1/36 ,  G01N15/06 ,  C07H21/04

CPC分类号： B82Y30/00 ,  B82Y15/00 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6869 ,  C12Q2600/156 ,  C12Q2563/113 ,  C12Q2525/197 ,  C12Q2525/117

摘要： A method of detecting a nucleic acid (e.g., DNA, RNA) that contains at least one preselected base (e.g., adenine, guanine, 6-mercaptoguanine, 8-oxo-guanine, and 8-oxo-adenine) comprises (a) reacting the nucleic acid with a transition metal complex capable of oxidizing the preselected base in an oxidation-reduction reaction; (b) detecting the oxidation-reduction reaction; and (c) determining the presence or absence of the nucleic acid from the detected oxidation-reduction reaction at the preselected base. The method may be used in a variety of applications, including DNA sequencing, diagnostic assays, and quantitative analysis.

摘要翻译： 检测含有至少一个预选碱基（例如腺嘌呤，鸟嘌呤，6-巯基鸟嘌呤，8-氧代 - 鸟嘌呤和8-氧代腺嘌呤）的核酸（例如DNA，RNA）的方法包括：（a）使 具有能够在氧化还原反应中氧化预选碱的过渡金属络合物的核酸; （b）检测氧化还原反应; 和（c）从预选碱基处检测到的氧化还原反应确定核酸的存在或不存在。 该方法可用于多种应用，包括DNA测序，诊断测定和定量分析。