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1.发明授权Methods of detecting lesions in the platelet-activating factor acetylhydrolase gene 失效检测血小板活化因子乙酰水解酶基因病变的方法
公开(公告)号：US5605801A
公开(公告)日：1997-02-25
申请号：US478465
申请日：1995-06-07
申请人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Hai L. Trong , Larry W. Tjoelker , Cheryl L. Wilder
发明人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Hai L. Trong , Larry W. Tjoelker , Cheryl L. Wilder
IPC分类号： G01N33/53 , A61K38/00 , A61K38/43 , A61K38/46 , A61K39/395 , A61P1/04 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P11/16 , A61P15/00 , A61P17/00 , A61P29/00 , A61P31/04 , A61P37/00 , A61P43/00 , C07H21/04 , C07K16/40 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/06 , C12N5/10 , C12N9/18 , C12N15/02 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/68 , C12R1/19 , C12R1/91 , G01N33/573 , G01N33/577
CPC分类号： C07K16/40 , C12N9/18 , A61K38/00 , C07K2317/24
摘要： The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful in regulating pathological inflammatory events. Furthermore provided are therapeutic and diagnostic methods using such polynucleotide sequences and platelet-activating factor acethylhydrolase products.
摘要翻译： 本发明提供了纯化和分离的编码人血浆血小板活化因子乙酰水解酶的多核苷酸序列。 还提供了用于重组生产血小板活化因子乙酰水解酶产物的材料和方法，其预期可用于调节病理性炎症事件。 此外提供了使用这种多核苷酸序列和血小板活化因子乙酰水解酶产物的治疗和诊断方法。
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公开(公告)号：US5532152A
公开(公告)日：1996-07-02
申请号：US470187
申请日：1995-06-06
申请人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Larry W. Tjoelker , Cheryl L. Wilder , Hai Trong
发明人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Larry W. Tjoelker , Cheryl L. Wilder , Hai Trong
IPC分类号： G01N33/53 , A61K38/00 , A61K38/43 , A61K38/46 , A61K39/395 , A61P1/04 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P11/16 , A61P15/00 , A61P17/00 , A61P29/00 , A61P31/04 , A61P37/00 , A61P43/00 , C07H21/04 , C07K16/40 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/06 , C12N5/10 , C12N9/18 , C12N15/02 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/68 , C12R1/19 , C12R1/91 , G01N33/573 , G01N33/577 , C12N1/15
CPC分类号： C07K16/40 , C12N9/18 , A61K38/00 , C07K2317/24
摘要： The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful in regulating pathological inflammatory events.
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公开(公告)号：US6146625A
公开(公告)日：2000-11-14
申请号：US10715
申请日：1998-01-22
申请人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Hai Le Trong , Larry W. Tjoelker , Cheryl L. Wilder
发明人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Hai Le Trong , Larry W. Tjoelker , Cheryl L. Wilder
CPC分类号： C12N9/18 , A61K38/00 , C07K2317/24
摘要： The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful in regulating pathological inflammatory events.
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公开(公告)号：US5847088A
公开(公告)日：1998-12-08
申请号：US485938
申请日：1995-06-07
申请人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Hai Le Trong , Larry W. Tjoelker , Cheryl L. Wilder
发明人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Hai Le Trong , Larry W. Tjoelker , Cheryl L. Wilder
CPC分类号： C07K16/40 , C12N9/18 , A61K38/00 , C07K2317/24
摘要： The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful in regulating pathological inflammatory events.
摘要翻译： 本发明提供了纯化和分离的编码人血浆血小板活化因子乙酰水解酶的多核苷酸序列。 还提供了用于重组产生血小板活化因子乙酰水解酶产物的材料和方法，其预期可用于调节病理性炎症事件。
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5.发明授权Methods of detecting platelet-activating factor acetylhydrolase using antibodies 失效使用抗体检测血小板活化因子乙酰水解酶的方法
公开(公告)号：US5698403A
公开(公告)日：1997-12-16
申请号：US483140
申请日：1995-06-07
申请人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Hai Le Trong , Larry W. Tjoelker , Cheryl L. Wilder
发明人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Hai Le Trong , Larry W. Tjoelker , Cheryl L. Wilder
IPC分类号： G01N33/53 , A61K38/00 , A61K38/43 , A61K38/46 , A61K39/395 , A61P1/04 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P11/16 , A61P15/00 , A61P17/00 , A61P29/00 , A61P31/04 , A61P37/00 , A61P43/00 , C07H21/04 , C07K16/40 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/06 , C12N5/10 , C12N9/18 , C12N15/02 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/68 , C12R1/19 , C12R1/91 , G01N33/573 , G01N33/577
CPC分类号： C07K16/40 , C12N9/18 , A61K38/00 , C07K2317/24
摘要： The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful in regulating pathological inflammatory events.
摘要翻译： 本发明提供了纯化和分离的编码人血浆血小板活化因子乙酰水解酶的多核苷酸序列。 还提供了用于重组产生血小板活化因子乙酰水解酶产物的材料和方法，其预期可用于调节病理性炎症事件。
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公开(公告)号：US6045794A
公开(公告)日：2000-04-04
申请号：US328474
申请日：1999-06-09
申请人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Hai Le Trong , Larry W. Tjoelker , Cheryl L. Wilder
发明人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Hai Le Trong , Larry W. Tjoelker , Cheryl L. Wilder
CPC分类号： C12N9/18 , A61K38/00 , C07K2317/24
摘要： The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful in regulating pathological inflammatory events.
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公开(公告)号：US5656431A
公开(公告)日：1997-08-12
申请号：US483232
申请日：1995-06-07
申请人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Hai Le Trong , Larry W. Tjoelker , Cheryl L. Wilder
发明人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Hai Le Trong , Larry W. Tjoelker , Cheryl L. Wilder
CPC分类号： C07K16/40 , C12N9/18 , A61K38/00 , C07K2317/24
摘要： The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful in regulating pathological inflammatory events.
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公开(公告)号：US5641669A
公开(公告)日：1997-06-24
申请号：US318905
申请日：1994-10-06
申请人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Hai Le Trong , Larry W. Tjoelker , Cheryl L. Wilder
发明人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Hai Le Trong , Larry W. Tjoelker , Cheryl L. Wilder
IPC分类号： G01N33/53 , A61K38/00 , A61K38/43 , A61K38/46 , A61K39/395 , A61P1/04 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P11/16 , A61P15/00 , A61P17/00 , A61P29/00 , A61P31/04 , A61P37/00 , A61P43/00 , C07H21/04 , C07K16/40 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/06 , C12N5/10 , C12N9/18 , C12N15/02 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/68 , C12R1/19 , C12R1/91 , G01N33/573 , G01N33/577 , C12N9/14
CPC分类号： C07K16/40 , C12N9/18 , A61K38/00 , C07K2317/24
摘要： The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful in regulating pathological inflammatory events.
摘要翻译： 本发明提供了纯化和分离的编码人血浆血小板活化因子乙酰水解酶的多核苷酸序列。 还提供了用于重组生产血小板活化因子乙酰水解酶产物的材料和方法，其预期可用于调节病理性炎症事件。
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公开(公告)号：US06203790B1
公开(公告)日：2001-03-20
申请号：US09577758
申请日：2000-05-23
申请人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Hai Le Trong , Larry W. Tjoelker , Cheryl L. Wilder
发明人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Hai Le Trong , Larry W. Tjoelker , Cheryl L. Wilder
IPC分类号： A61K3846
CPC分类号： C12N9/18 , A61K38/00 , C07K2317/24
摘要： The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful in regulating pathological inflammatory events.
摘要翻译： 本发明提供了纯化和分离的编码人血浆血小板活化因子乙酰水解酶的多核苷酸序列。 还提供了用于重组产生血小板活化因子乙酰水解酶产物的材料和方法，其预期可用于调节病理性炎症事件。
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10.发明授权
公开(公告)号：US6099836A
公开(公告)日：2000-08-08
申请号：US100546
申请日：1998-06-19
申请人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Hai Le Trong , Larry W. Tjoelker , Cheryl L. Wilder
发明人： Lawrence S. Cousens , Christine D. Eberhardt , Patrick Gray , Hai Le Trong , Larry W. Tjoelker , Cheryl L. Wilder
CPC分类号： C12N9/18 , A61K38/00 , C07K2317/24
摘要： The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful in regulating pathological inflammatory events. Specifically disclosed are methods for the treatment of reperfusion injury using platelet-activating factor acetylhydrolase products.
摘要翻译： 本发明提供了纯化和分离的编码人血浆血小板活化因子乙酰水解酶的多核苷酸序列。 还提供了用于重组产生血小板活化因子乙酰水解酶产物的材料和方法，其预期可用于调节病理性炎症事件。 具体公开的是使用血小板活化因子乙酰水解酶产物治疗再灌注损伤的方法。
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