公开(公告)号：US06288253B1

公开(公告)日：2001-09-11

申请号：US09350705

申请日：1999-07-09

申请人： Leo E. Manzer ,  Prabhat Arya ,  Howard Alper ,  Sheila Christine Bourque ,  Gary Jefferson

发明人： Leo E. Manzer ,  Prabhat Arya ,  Howard Alper ,  Sheila Christine Bourque ,  Gary Jefferson

IPC分类号： C07F708

CPC分类号： B01J31/2404 ,  B01J31/064 ,  B01J31/1633 ,  B01J31/1658 ,  B01J2231/321 ,  B01J2231/4261 ,  B01J2531/822 ,  B01J2531/824 ,  C07B37/04 ,  C07C45/50 ,  Y02P20/588 ,  Y10S977/754 ,  Y10S977/773 ,  Y10S977/775 ,  C07C47/277 ,  C07C47/228

摘要： Dendrimers were directly and covalently attached to solid supports via siloxy bonds. After complexation with transition metals, the dendrimers were used as catalysts. The supported dendrimers were stable and easily separated from the reaction mixture.

摘要翻译： 树枝状聚合物通过硅氧键直接并共价连接到固体支持物上。 与过渡金属络合后，树枝状聚合物用作催化剂。 支撑的树枝状大分子是稳定的，容易从反应混合物中分离出来。

公开(公告)号：US07132458B2

公开(公告)日：2006-11-07

申请号：US10196695

申请日：2002-07-15

申请人： Graham Burton ,  Janusz Daroszewski ,  Jenny Phipps ,  Prabhat Arya

发明人： Graham Burton ,  Janusz Daroszewski ,  Jenny Phipps ,  Prabhat Arya

IPC分类号： A01N35/00 ,  A01N31/04 ,  A61K31/12 ,  A61K31/11 ,  A61K31/07

CPC分类号： C07K5/06139

摘要： This invention features fractionated oxidized carotenoid or retinoid mixtures, and individual components thereof, which are useful as cell-differentiation-inducing, anti-proliferative, anti-metastatic and anti-tumor agents. The mixtures and compounds of the invention can be used alone or in combination with other anticancer agents for the treatment of cancer.

公开(公告)号：US5354871A

公开(公告)日：1994-10-11

申请号：US46727

申请日：1993-04-16

申请人： Prabhat Arya ,  David Griller

发明人： Prabhat Arya ,  David Griller

IPC分类号： C07D207/46 ,  C07D495/04 ,  C07D403/12 ,  C07D495/02

CPC分类号： C07D495/04 ,  C07D207/46

摘要： Derivatives of 3,5-substituted pyrroline N-oxides having substituents in the 4-position have been prepared, with the 4-position substituents being selected from certain ester, polyether, and alkanoyl groups, the latter having components which bind to biological substrates. These specific derivatives are effective as spin traps for different types of free radicals to form persistent nitroxide adducts of extended half life. These adducts can be characterized by ESR spectrometry technique and provide information e.g. concerning the identification of free radicals.

摘要翻译： 已经制备了在4-位具有取代基的3,5-取代的吡咯啉N-氧化物的衍生物，其中4-位取代基选自某些酯，聚醚和烷酰基，后者具有结合生物底物的成分。 这些具体的衍生物作为不同类型的自由基的自旋捕获剂是有效的，以形成延长的半衰期的持久的氮氧化物加合物。 这些加合物可以通过ESR分光技术进行表征，并提供信息。 关于自由基的鉴定。