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公开(公告)号：US06380163B1
公开(公告)日：2002-04-30
申请号：US07995106
申请日：1992-12-22
申请人： Leo Martis , Ron Burke , Dirk Faict
发明人： Leo Martis , Ron Burke , Dirk Faict
IPC分类号： A61K3808
CPC分类号： A61K38/018 , A61K38/02 , A61M1/287
摘要： The present invention provides an improved dialysis solution. The improved dialysis solution provides for the use of specific polypeptides as an osmotic agent with an additional osmotic agent such as dextrose. To this end, the present invention provides, in an embodiment, a peritoneal dialysis solution comprising as osmotic agents approximately 0.25 to about 4.0% (w/v) polypeptides and approximately 0.5% to about 4.0% (w/v) dextrose. The polypeptides have well defined characteristics.
摘要翻译： 本发明提供了一种改进的透析溶液。 改进的透析溶液提供使用特定多肽作为渗透剂与另外的渗透剂如葡萄糖。 为此，在一个实施方案中，本发明提供包含约0.25至约4.0％（w / v）多肽和约0.5％至约4.0％（w / v）葡萄糖的渗透剂的腹膜透析溶液。 多肽具有明确的特征。
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公开(公告)号：US06730660B2
公开(公告)日：2004-05-04
申请号：US09909733
申请日：2001-07-20
申请人： Leo Martis , Ron Burke , Dirk Faict
发明人： Leo Martis , Ron Burke , Dirk Faict
IPC分类号： A61K3806
CPC分类号： A61K38/018 , A61K38/02 , A61M1/287
摘要： The present invention provides an improved dialysis solution. The improved dialysis solution provides for the use of specific polypeptides as an osmotic agent with an additional osmotic agent such as dextrose. To this end, the present invention provides, in an embodiment, a peritoneal dialysis solution comprising as osmotic agents approximately 0.25 to about 4.0% (w/v) polypeptides and approximately 0.5% to about 4.0% (w/v) dextrose. The polypeptides have well defined characteristics.
摘要翻译： 本发明提供了一种改进的透析溶液。 改进的透析溶液提供使用特定多肽作为渗透剂与另外的渗透剂如葡萄糖。 为此，在一个实施方案中，本发明提供包含约0.25至约4.0％（w / v）多肽和约0.5％至约4.0％（w / v）葡萄糖的渗透剂的腹膜透析溶液。 多肽具有明确的特征。
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公开(公告)号：US06475529B2
公开(公告)日：2002-11-05
申请号：US09918328
申请日：2001-07-30
申请人： Annick Duponchelle , Dirk Faict , Patrick Balteau , Jean-Pierre Hartman , Leo Martis , Francesco Peluso
发明人： Annick Duponchelle , Dirk Faict , Patrick Balteau , Jean-Pierre Hartman , Leo Martis , Francesco Peluso
IPC分类号： A61K3300
CPC分类号： A61M1/287 , A61K33/14 , A61M1/1654 , A61K33/10 , A61K2300/00
摘要： The present invention provides devices and methods for stabilizing bicarbonate-based solutions for peritoneal dialysis or hemofiltration. The bicarbonate-based solutions of the present invention are formulated and stored in at least two parts—an alkaline bicarbonate concentrate and an acidic concentrate. The alkaline bicarbonate concentrate is adjusted to have a pH of about 8.6 to 10.0. The acidic concentrate is adjusted to have a stable, acidic pH ranging from about 1.0 to 3.0. Upon mixing, although some variation in the pH of the mixed bicarbonate solution exists, the inventors have discovered that with the appropriate selection of the parameters of the concentrates, the pH of the mixed solution is always within an acceptable physiological range.
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4.发明授权Bicarbonate-based solution in two parts for peritoneal dialysis or substitution in continuous renal replacement therapy 失效碳酸氢盐溶液在两部分用于腹膜透析或连续肾替代治疗中的替代公开(公告)号：US06309673B1
公开(公告)日：2001-10-30
申请号：US09393743
申请日：1999-09-10
申请人： Annick Duponchelle , Dirk Faict , Patrick Balteau , Jean-Pierre Hartman , Leo Martis , Francesco Peluso
发明人： Annick Duponchelle , Dirk Faict , Patrick Balteau , Jean-Pierre Hartman , Leo Martis , Francesco Peluso
IPC分类号： A61K3300
CPC分类号： A61M1/287 , A61K33/14 , A61M1/1654 , A61K33/10 , A61K2300/00
摘要： The present invention provides devices and methods for stabilizing bicarbonate-based solutions for peritoneal dialysis or hemofiltration. The bicarbonate-based solutions of the present invention are formulated and stored in at least two parts—an alkaline bicarbonate concentrate and an acidic concentrate. The alkaline bicarbonate concentrate is adjusted to have a pH of about 8.6 to 10.0. The acidic concentrate is adjusted to have a stable, acidic pH ranging from about 1.0 to 3.0. Upon mixing, although some variation in the pH of the mixed bicarbonate solution exists, the inventors have discovered that with the appropriate selection of the parameters of the concentrates, the pH of the mixed solution is always within an acceptable physiological range.
摘要翻译： 本发明提供用于稳定用于腹膜透析或血液滤过的基于碳酸氢根的溶液的装置和方法。 将本发明的基于碳酸氢盐的溶液配制并储存在至少两部分中 - 碱性碳酸氢盐浓缩物和酸性浓缩物。 将碱式碳酸氢盐浓缩物调节至约8.6至10.0的pH。 将酸性浓缩物调节至具有约1.0至3.0的稳定的酸性pH。 在混合时，虽然存在混合碳酸氢盐溶液的pH的一些变化，本发明人已经发现，通过适当选择浓缩物的参数，混合溶液的pH总是在可接受的生理范围内。
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公开(公告)号：US20070003637A1
公开(公告)日：2007-01-04
申请号：US11531121
申请日：2006-09-12
申请人： Paola Elisabettini , Jean-Paul Menneguerre , Jerome Colas , Christian Renaux , Jose Divino , Dirk Faict , Isabelle Wilmet
发明人： Paola Elisabettini , Jean-Paul Menneguerre , Jerome Colas , Christian Renaux , Jose Divino , Dirk Faict , Isabelle Wilmet
IPC分类号： A61K33/00
CPC分类号： A61K33/14
摘要： Bicarbonate containing solutions for use during medical treatment are provided. The bicarbonate containing solution of the present invention includes at least two separate components including a bicarbonate concentrate and an electrolyte concentrate which can be readily and sterilely mixed to form a ready-to-use formulation for patient administration, particularly as applied to the treatment of acute renal failure associated with critically ill patients in an intensive care setting.
摘要翻译： 提供了在医疗中使用的含碳酸氢盐溶液。 本发明的含碳酸氢盐溶液包括至少两种分离的组分，包括碳酸氢盐浓缩物和电解质浓缩物，其可容易地和无菌地混合以形成用于患者给药的即用型制剂，特别是用于治疗急性 与重症监护病房危重病人相关的肾衰竭。
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公开(公告)号：US5560403A
公开(公告)日：1996-10-01
申请号：US424672
申请日：1995-04-18
申请人： Patrick Balteau , Dirk Faict , Francesco Peluso
发明人： Patrick Balteau , Dirk Faict , Francesco Peluso
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/2027 , A61M1/28
摘要： A multiple chamber container for mixing and administering a plurality of products. The container has at least two chambers separated by a seal line. A frangible connector is situated between the two chambers for mixing the products contained within the chambers as desired. Each chamber has at least one port for filling of product into the chamber. The ports are located on the same exterior side of the container such that the chambers can be filled without folding the bag and by using existing filling equipment.
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7.发明申请公开(公告)号：US20070293441A1
公开(公告)日：2007-12-20
申请号：US11766471
申请日：2007-06-21
申请人： Carolyn Choo , Dirk Faict , Alfredo Rodriquez
发明人： Carolyn Choo , Dirk Faict , Alfredo Rodriquez
CPC分类号： A61L2/0011 , A61L2/0023 , A61L2/02 , A61L2/04 , B65B55/02
摘要： The present disclosure provides a sterilized medical system that includes an ultra high pressure sterilized glucose solution in a container. The sterile glucose solution may contain less than about 40 ppm total glucose degradation product. The glucose solution may be a ready-to-use infusion solution disposed in a single chamber container.
摘要翻译： 本公开提供了一种在容器中包括超高压灭菌葡萄糖溶液的灭菌医疗系统。 无菌葡萄糖溶液可含有小于约40ppm的总葡萄糖降解产物。 葡萄糖溶液可以是设置在单室容器中的即用型输注溶液。
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公开(公告)号：US07141544B2
公开(公告)日：2006-11-28
申请号：US10683549
申请日：2003-10-10
申请人： Fabian Somers , Dirk Faict
发明人： Fabian Somers , Dirk Faict
IPC分类号： A61K38/22
CPC分类号： A61K38/06 , A61K38/05 , A61K38/1816 , A61K2300/00
摘要： The present invention relates to stable pharmaceutical protein formulations that are stabilized using peptide stabilizers selected from the group consisting of Gly-Gly, Gly-Gly-Gly, Gly-Tyr, Gly-Phe, Gly-His, Gly-Asp, Gly-Ala, Ala-Gly, Ala-Ala, derivatives thereof and mixtures thereof. Furthermore, the present invention relates to stable pharmaceutical formulations comprising erythropoietin and peptide stabilizers selected from dipeptides, tripeptides, tetrapeptides, pentapeptides, and mixtures thereof. In addition to peptide stabilizers, the formulations may contain surfactants.
摘要翻译： 本发明涉及稳定的药物蛋白质制剂，其使用选自Gly-Gly，Gly-Gly-Gly，Gly-Tyr，Gly-Phe，Gly-His，Gly-Asp，Gly-Ala ，Ala-Gly，Ala-Ala，其衍生物及其混合物。 此外，本发明涉及包含促红细胞生成素和选自二肽，三肽，四肽，五肽及其混合物的肽稳定剂的稳定药物制剂。 除了肽稳定剂之外，制剂可以含有表面活性剂。
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公开(公告)号：US07122210B2
公开(公告)日：2006-10-17
申请号：US10044234
申请日：2002-01-11
申请人： Paola Elisabettini , Jean-Paul Menneguerre , Jerome Colas , Christian Renaux , Jose Divino , Dirk Faict , Isabelle Wilmet
发明人： Paola Elisabettini , Jean-Paul Menneguerre , Jerome Colas , Christian Renaux , Jose Divino , Dirk Faict , Isabelle Wilmet
CPC分类号： A61K33/14
摘要： Bicarbonate containing solutions for use during medical treatment are provided. The bicarbonate containing solution of the present invention includes at least two separate components including a bicarbonate concentrate and an electrolyte concentrate which can be readily and sterilely mixed to form a ready-to-use formulation for patient administration, particularly as applied to the treatment of acute renal failure associated with critically ill patients in an intensive care setting.
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公开(公告)号：US20060226080A1
公开(公告)日：2006-10-12
申请号：US11425911
申请日：2006-06-22
申请人： Bart Degreve , Marion Gericke , Dirk Faict , Annick Duponchelle
发明人： Bart Degreve , Marion Gericke , Dirk Faict , Annick Duponchelle
IPC分类号： B01D11/00
CPC分类号： A61K33/00 , A61K9/0019 , A61K9/08 , A61K9/5036 , A61M1/287
摘要： Dialysis solutions and methods of manufacturing and using same are provided. The dialysis solution at least includes three solution parts that are separately stored and sterilized at an effective pH to promote the stabilization of the solution parts including a pH-sensitive solution part that has, for example, a pH-sensitive osmotic agent, such as a glucose polymer. The solution parts are admixed to form a ready-to-use solution with a physiologically acceptable pH.
摘要翻译： 提供了透析溶液及其制造和使用方法。 所述透析溶液至少包括三个溶液部分，其在有效pH下分开存储和灭菌，以促进溶液部分的稳定化，包括pH敏感溶液部分，其具有例如pH敏感性渗透剂，例如 葡萄糖聚合物。 将溶液部分混合以形成具有生理上可接受的pH的即用型溶液。
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