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公开(公告)号：US07141544B2
公开(公告)日：2006-11-28
申请号：US10683549
申请日：2003-10-10
申请人： Fabian Somers , Dirk Faict
发明人： Fabian Somers , Dirk Faict
IPC分类号： A61K38/22
CPC分类号： A61K38/06 , A61K38/05 , A61K38/1816 , A61K2300/00
摘要： The present invention relates to stable pharmaceutical protein formulations that are stabilized using peptide stabilizers selected from the group consisting of Gly-Gly, Gly-Gly-Gly, Gly-Tyr, Gly-Phe, Gly-His, Gly-Asp, Gly-Ala, Ala-Gly, Ala-Ala, derivatives thereof and mixtures thereof. Furthermore, the present invention relates to stable pharmaceutical formulations comprising erythropoietin and peptide stabilizers selected from dipeptides, tripeptides, tetrapeptides, pentapeptides, and mixtures thereof. In addition to peptide stabilizers, the formulations may contain surfactants.
摘要翻译： 本发明涉及稳定的药物蛋白质制剂，其使用选自Gly-Gly，Gly-Gly-Gly，Gly-Tyr，Gly-Phe，Gly-His，Gly-Asp，Gly-Ala ，Ala-Gly，Ala-Ala，其衍生物及其混合物。 此外，本发明涉及包含促红细胞生成素和选自二肽，三肽，四肽，五肽及其混合物的肽稳定剂的稳定药物制剂。 除了肽稳定剂之外，制剂可以含有表面活性剂。
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公开(公告)号：US20050080011A1
公开(公告)日：2005-04-14
申请号：US10683549
申请日：2003-10-10
申请人： Fabian Somers , Dirk Faict
发明人： Fabian Somers , Dirk Faict
CPC分类号： A61K38/06 , A61K38/05 , A61K38/1816 , A61K2300/00
摘要： The present invention relates to stable pharmaceutical protein formulations that are stabilized using peptide stabilizers selected from the group consisting of Gly-Gly, Gly-Gly-Gly, Gly-Tyr, Gly-Phe, Gly-His, Gly-Asp, Gly-Ala, Ala-Gly, Ala-Ala, derivatives thereof and mixtures thereof. Furthermore, the present invention relates to stable pharmaceutical formulations comprising erythropoietin and peptide stabilizers selected from dipeptides, tripeptides, tetrapeptides, pentapeptides, and mixtures thereof. In addition to peptide stabilizers, the formulations may contain surfactants.
摘要翻译： 本发明涉及稳定的药物蛋白质制剂，其使用选自Gly-Gly，Gly-Gly-Gly，Gly-Tyr，Gly-Phe，Gly-His，Gly-Asp，Gly-Ala ，Ala-Gly，Ala-Ala，其衍生物及其混合物。 此外，本发明涉及包含促红细胞生成素和选自二肽，三肽，四肽，五肽及其混合物的肽稳定剂的稳定药物制剂。 除了肽稳定剂之外，制剂可以含有表面活性剂。
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公开(公告)号：US20070003637A1
公开(公告)日：2007-01-04
申请号：US11531121
申请日：2006-09-12
申请人： Paola Elisabettini , Jean-Paul Menneguerre , Jerome Colas , Christian Renaux , Jose Divino , Dirk Faict , Isabelle Wilmet
发明人： Paola Elisabettini , Jean-Paul Menneguerre , Jerome Colas , Christian Renaux , Jose Divino , Dirk Faict , Isabelle Wilmet
IPC分类号： A61K33/00
CPC分类号： A61K33/14
摘要： Bicarbonate containing solutions for use during medical treatment are provided. The bicarbonate containing solution of the present invention includes at least two separate components including a bicarbonate concentrate and an electrolyte concentrate which can be readily and sterilely mixed to form a ready-to-use formulation for patient administration, particularly as applied to the treatment of acute renal failure associated with critically ill patients in an intensive care setting.
摘要翻译： 提供了在医疗中使用的含碳酸氢盐溶液。 本发明的含碳酸氢盐溶液包括至少两种分离的组分，包括碳酸氢盐浓缩物和电解质浓缩物，其可容易地和无菌地混合以形成用于患者给药的即用型制剂，特别是用于治疗急性 与重症监护病房危重病人相关的肾衰竭。
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公开(公告)号：US5560403A
公开(公告)日：1996-10-01
申请号：US424672
申请日：1995-04-18
申请人： Patrick Balteau , Dirk Faict , Francesco Peluso
发明人： Patrick Balteau , Dirk Faict , Francesco Peluso
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/2027 , A61M1/28
摘要： A multiple chamber container for mixing and administering a plurality of products. The container has at least two chambers separated by a seal line. A frangible connector is situated between the two chambers for mixing the products contained within the chambers as desired. Each chamber has at least one port for filling of product into the chamber. The ports are located on the same exterior side of the container such that the chambers can be filled without folding the bag and by using existing filling equipment.
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5.发明申请公开(公告)号：US20070293441A1
公开(公告)日：2007-12-20
申请号：US11766471
申请日：2007-06-21
申请人： Carolyn Choo , Dirk Faict , Alfredo Rodriquez
发明人： Carolyn Choo , Dirk Faict , Alfredo Rodriquez
CPC分类号： A61L2/0011 , A61L2/0023 , A61L2/02 , A61L2/04 , B65B55/02
摘要： The present disclosure provides a sterilized medical system that includes an ultra high pressure sterilized glucose solution in a container. The sterile glucose solution may contain less than about 40 ppm total glucose degradation product. The glucose solution may be a ready-to-use infusion solution disposed in a single chamber container.
摘要翻译： 本公开提供了一种在容器中包括超高压灭菌葡萄糖溶液的灭菌医疗系统。 无菌葡萄糖溶液可含有小于约40ppm的总葡萄糖降解产物。 葡萄糖溶液可以是设置在单室容器中的即用型输注溶液。
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公开(公告)号：US07122210B2
公开(公告)日：2006-10-17
申请号：US10044234
申请日：2002-01-11
申请人： Paola Elisabettini , Jean-Paul Menneguerre , Jerome Colas , Christian Renaux , Jose Divino , Dirk Faict , Isabelle Wilmet
发明人： Paola Elisabettini , Jean-Paul Menneguerre , Jerome Colas , Christian Renaux , Jose Divino , Dirk Faict , Isabelle Wilmet
CPC分类号： A61K33/14
摘要： Bicarbonate containing solutions for use during medical treatment are provided. The bicarbonate containing solution of the present invention includes at least two separate components including a bicarbonate concentrate and an electrolyte concentrate which can be readily and sterilely mixed to form a ready-to-use formulation for patient administration, particularly as applied to the treatment of acute renal failure associated with critically ill patients in an intensive care setting.
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公开(公告)号：US20060226080A1
公开(公告)日：2006-10-12
申请号：US11425911
申请日：2006-06-22
申请人： Bart Degreve , Marion Gericke , Dirk Faict , Annick Duponchelle
发明人： Bart Degreve , Marion Gericke , Dirk Faict , Annick Duponchelle
IPC分类号： B01D11/00
CPC分类号： A61K33/00 , A61K9/0019 , A61K9/08 , A61K9/5036 , A61M1/287
摘要： Dialysis solutions and methods of manufacturing and using same are provided. The dialysis solution at least includes three solution parts that are separately stored and sterilized at an effective pH to promote the stabilization of the solution parts including a pH-sensitive solution part that has, for example, a pH-sensitive osmotic agent, such as a glucose polymer. The solution parts are admixed to form a ready-to-use solution with a physiologically acceptable pH.
摘要翻译： 提供了透析溶液及其制造和使用方法。 所述透析溶液至少包括三个溶液部分，其在有效pH下分开存储和灭菌，以促进溶液部分的稳定化，包括pH敏感溶液部分，其具有例如pH敏感性渗透剂，例如 葡萄糖聚合物。 将溶液部分混合以形成具有生理上可接受的pH的即用型溶液。
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公开(公告)号：US08075544B2
公开(公告)日：2011-12-13
申请号：US12698570
申请日：2010-02-02
申请人： Francesco Peluso , Tranaeus Anders , Dirk Faict , Patrick R. Balteau , Paul-Andre Gollier , Jean-Luc Dewez , Eric J. Henaut , Vincent Houwaert , Philippe Lambert
发明人： Francesco Peluso , Tranaeus Anders , Dirk Faict , Patrick R. Balteau , Paul-Andre Gollier , Jean-Luc Dewez , Eric J. Henaut , Vincent Houwaert , Philippe Lambert
IPC分类号： A61B19/00
CPC分类号： B32B27/08 , A61J1/10 , A61J1/2024 , A61J1/2093 , A61M2207/00 , B29C65/02 , B29C65/08 , B29C65/18 , B29C65/38 , B29C65/76 , B29C65/8207 , B29C65/8215 , B29C65/8223 , B29C66/1122 , B29C66/3452 , B29C66/3472 , B29C66/43 , B29C66/53262 , B29C66/71 , B29C66/723 , B29C66/73115 , B29C66/73772 , B29C66/73774 , B29C66/73776 , B29C66/73921 , B29C66/91411 , B29C66/919 , B29C66/91921 , B29C66/949 , B29K2023/0625 , B29K2023/083 , B29K2023/12 , B29K2077/00 , B29K2105/0088 , B29K2995/0039 , B29K2995/0041 , B29L2009/00 , B29L2031/7148 , B32B27/32 , B32B27/34 , B32B2323/046 , B32B2323/10 , B32B2377/00 , B32B2439/80 , B29K2021/003 , B29K2019/00
摘要： A container is provided comprising a body defined, at least in part, by a film, the body including at least one side seal, at least two chambers separated, at least in part, by a peelable seal, and the film including a sealant layer having a bimodal thermal behavior such that the side seal is a permanent seal and the peelable seal can, at least in part, be separated.
摘要翻译： 提供了一种容器，其包括至少部分地由膜限定的主体，所述主体包括至少一个侧密封件，至少两个室，至少部分地由可剥离的密封件分离，并且所述膜包括密封剂层 具有双峰热行为，使得侧密封件是永久性密封件，并且可剥离密封件可以至少部分地分离。
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公开(公告)号：US20100133278A1
公开(公告)日：2010-06-03
申请号：US12698570
申请日：2010-02-02
申请人： Francesco Peluso , Tranaeus Anders , Dirk Faict , Patrick R. Balteau , Paul-Andre Gollier , Jean-Luc Dewez , Eric J. Henaut , Vincent Houwaert , Philippe Lambert
发明人： Francesco Peluso , Tranaeus Anders , Dirk Faict , Patrick R. Balteau , Paul-Andre Gollier , Jean-Luc Dewez , Eric J. Henaut , Vincent Houwaert , Philippe Lambert
IPC分类号： B65D25/04
CPC分类号： B32B27/08 , A61J1/10 , A61J1/2024 , A61J1/2093 , A61M2207/00 , B29C65/02 , B29C65/08 , B29C65/18 , B29C65/38 , B29C65/76 , B29C65/8207 , B29C65/8215 , B29C65/8223 , B29C66/1122 , B29C66/3452 , B29C66/3472 , B29C66/43 , B29C66/53262 , B29C66/71 , B29C66/723 , B29C66/73115 , B29C66/73772 , B29C66/73774 , B29C66/73776 , B29C66/73921 , B29C66/91411 , B29C66/919 , B29C66/91921 , B29C66/949 , B29K2023/0625 , B29K2023/083 , B29K2023/12 , B29K2077/00 , B29K2105/0088 , B29K2995/0039 , B29K2995/0041 , B29L2009/00 , B29L2031/7148 , B32B27/32 , B32B27/34 , B32B2323/046 , B32B2323/10 , B32B2377/00 , B32B2439/80 , B29K2021/003 , B29K2019/00
摘要： A container is provided comprising a body defined, at least in part, by a film, the body including at least one side seal, at least two chambers separated, at least in part, by a peelable seal, and the film including a sealant layer having a bimodal thermal behavior such that the side seal is a permanent seal and the peelable seal can, at least in part, be separated.
摘要翻译： 提供了一种容器，其包括至少部分地由膜限定的主体，所述主体包括至少一个侧密封件，至少两个室，至少部分地由可剥离密封件分离，并且所述膜包括密封剂层 具有双峰热行为，使得侧密封件是永久性密封件，并且可剥离密封件可以至少部分地分离。
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公开(公告)号：US07445801B2
公开(公告)日：2008-11-04
申请号：US10165482
申请日：2002-06-07
IPC分类号： A61K33/00 , A61K31/047 , A61K31/195 , A61K31/7004 , A61P7/08 , B01D61/24
CPC分类号： A61K33/10 , A61K45/06 , A61M1/1654 , A61M1/287
摘要： Stable single bicarbonate-based solutions are provided. The bicarbonate-based single solution of the present invention includes at least calcium and bicarbonate and is stored or packaged in a sterile manner within a container with a gas barrier. The single solutions of the present invention can remain stable for three months or more. In this regard, the stable and single bicarbonate-based solutions of the present invention can be readily and effectively used during medical therapy, such as dialysis therapy.
摘要翻译： 提供稳定的基于碳酸氢盐的溶液。 本发明的基于碳酸氢根的单一溶液至少包括钙和碳酸氢盐，并以无菌方式储存或包装在具有气体屏障的容器内。 本发明的单一溶液可以保持稳定三个月或更长时间。 在这方面，本发明的稳定和单一的碳酸氢根溶液可以在药物治疗期间，例如透析治疗中容易且有效地使用。
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