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1.发明授权Internet-linked system for directory protocol based data storage, retrieval and analysis 有权用于基于目录协议的数据存储，检索和分析的互联网链接系统公开(公告)号：US07650351B2
公开(公告)日：2010-01-19
申请号：US11194964
申请日：2005-08-02
申请人： Leonard A. Herzenberg , David Rhodes Parks , Leonore A. Herzenberg , Wayne A. Moore , Vernon T Oi
发明人： Leonard A. Herzenberg , David Rhodes Parks , Leonore A. Herzenberg , Wayne A. Moore , Vernon T Oi
IPC分类号： G06F17/30
CPC分类号： G06Q10/10 , G06F17/30557 , G06F17/30569 , G06F19/00 , G06F19/28 , G06F19/324 , G16H10/60 , Y10S707/99942 , Y10S707/99945 , Y10S707/99948
摘要： The present invention is related to databases and the exchange of scientific information. Specifically the invention disclosed a unified scientific database that allows researchers to easily share their data with other researches. The present invention also allows for the ease of data collection, annotation, storage, management, retrieval and analysis of scientific data through and into the database. In addition, it allows for archival storage and retrieval of data collected directly from laboratory instruments to ensure data consistency for patent and other purposes. It also allows for ease of sharing data between laboratories in remote locations. The present invention also supports the automated creation of experimental protocols.
摘要翻译： 本发明涉及数据库和科学信息的交换。 具体地说，本发明公开了一个统一的科学数据库，使研究人员可以轻松地与其他研究分享其数据。 本发明还允许通过和进入数据库的数据收集，注释，存储，管理，检索和分析科学数据的容易性。 此外，它允许存档和检索从实验室仪器直接收集的数据，以确保专利和其他目的的数据一致性。 它还允许在偏远地区的实验室之间轻松共享数据。 本发明还支持实验协议的自动创建。
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2.发明授权Internet-linked system for directory protocol based data storage, retrieval and analysis 有权用于基于目录协议的数据存储，检索和分析的互联网链接系统公开(公告)号：US06947953B2
公开(公告)日：2005-09-20
申请号：US09860222
申请日：2001-05-18
申请人： Leonard A. Herzenberg , David Rhodes Parks , Leonore A. Herzenberg , Wayne A. Moore , Vernon T. Oi
发明人： Leonard A. Herzenberg , David Rhodes Parks , Leonore A. Herzenberg , Wayne A. Moore , Vernon T. Oi
CPC分类号： G06Q10/10 , G06F17/30557 , G06F17/30569 , G06F19/00 , G06F19/28 , G06F19/324 , G16H10/60 , Y10S707/99942 , Y10S707/99945 , Y10S707/99948
摘要： The present invention is related to databases and the exchange of scientific information. Specifically the invention disclosed a unified scientific database that allows researchers to easily share their data with other researches. The present invention also allows for the ease of data collection, annotation, storage, management, retrieval and analysis of scientific data through and into the database. In addition, it allows for archival storage and retrieval of data collected directly from laboratory instruments to ensure data consistency for patent and other purposes. It also allows for ease of sharing data between laboratories in remote locations. The present invention also supports the automated creation of experimental protocols.
摘要翻译： 本发明涉及数据库和科学信息的交换。 具体地说，本发明公开了一个统一的科学数据库，使研究人员可以轻松地与其他研究分享其数据。 本发明还允许通过和进入数据库的数据收集，注释，存储，管理，检索和分析科学数据的容易性。 此外，它允许存档和检索从实验室仪器直接收集的数据，以确保专利和其他目的的数据一致性。 它还允许在偏远地区的实验室之间轻松共享数据。 本发明还支持实验协议的自动创建。
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3.发明申请公开(公告)号：US20110282870A1
公开(公告)日：2011-11-17
申请号：US13105570
申请日：2011-05-11
CPC分类号： G01N15/1429 , G01N2015/149
摘要： The invention provides a system and method for selecting an optimal multimarker reagent combination for the identification and/or quantification of molecules in or on cells with or without reference to fluorescence or other properties of at least one fluorescent dye or other instrument-measurable atom or molecule associated directly or indirectly with the reagent combination. The method includes specifying, using a computer, a plurality of markers to be detected by a plurality of reagents, generating, using a computer, a plurality of reagent combinations comprising the plurality of reagents to detect the plurality of markers, wherein the reagent combinations are ranked according to at least one user-defined or system-defined criterion, and selecting the optimal reagent combination or providing a rank-ordered list of combinations.
摘要翻译： 本发明提供了一种用于选择最佳多标记试剂组合的系统和方法，用于鉴定和/或定量细胞中或细胞上或未参考至少一种荧光染料或其它可仪器测量的原子或分子的荧光或其它性质的分子 与试剂组合直接或间接相关。 该方法包括使用计算机指定要由多个试剂检测的多个标记物，使用计算机生成包含多个试剂的多个试剂组合以检测多个标记，其中所述试剂组合是 根据至少一个用户定义或系统定义的标准进行排序，以及选择最佳试剂组合或提供秩序列表的组合。
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4.发明授权System and method for selecting a multiparameter reagent combination and for automated fluorescence compensation 有权用于选择多参数试剂组合和自动荧光补偿的系统和方法公开(公告)号：US08731844B2
公开(公告)日：2014-05-20
申请号：US13105570
申请日：2011-05-11
CPC分类号： G01N15/1429 , G01N2015/149
摘要： The invention provides a system and method for selecting an optimal multimarker reagent combination for the identification and/or quantification of molecules in or on cells with or without reference to fluorescence or other properties of at least one fluorescent dye or other instrument-measurable atom or molecule associated directly or indirectly with the reagent combination. The method includes specifying, using a computer, a plurality of markers to be detected by a plurality of reagents, generating, using a computer, a plurality of reagent combinations comprising the plurality of reagents to detect the plurality of markers, wherein the reagent combinations are ranked according to at least one user-defined or system-defined criterion, and selecting the optimal reagent combination or providing a rank-ordered list of combinations.
摘要翻译： 本发明提供了一种用于选择最佳多标记试剂组合的系统和方法，用于鉴定和/或定量细胞中或细胞上或未参考至少一种荧光染料或其它可仪器测量的原子或分子的荧光或其它性质的分子 与试剂组合直接或间接相关。 该方法包括使用计算机指定要由多个试剂检测的多个标记物，使用计算机生成包含多个试剂的多个试剂组合以检测多个标记，其中所述试剂组合是 根据至少一个用户定义或系统定义的标准进行排序，以及选择最佳试剂组合或提供秩序列表的组合。
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公开(公告)号：US07981625B2
公开(公告)日：2011-07-19
申请号：US12421964
申请日：2009-04-10
IPC分类号： G01N33/53
CPC分类号： C40B40/12 , C07K16/3069 , G01N33/57434 , G01N2333/42 , G01N2400/10
摘要： Disclosed are methods for probing the immunogenic sugar moieties of prostate cancer cells. The methods detect a number of glyco-epitopes that are highly and differentially expressed among prostate cancers of various Gleason grades. The glyco-epitopes exist on the surfaces of prostate cells. The methods also comprise the detection of autoantibodies in prostate cancer subjects. The antibodies bound to a glyco-motif of N-glycans that is normally “cryptic.” This target is highly expressed in prostate cancers. Lectins and antibodies that detect these glyco-epitopes that expressed in prostate cancer tissues include Euonymus europaeus lectin (EEL); Psophocarpus Tetragonolobus Lectin-I (PTL-I); Griffonia Simplicifolia Lectin-I-A4 (GSL-I-A4); Griffonia Simplicifolia Lectin-I-B4 (GSL-I-B4); Sambucus nigra I agglutinin (SNA-I; Phaseolus vulgaris-L (PHA-L; Galanthus nivalis agglutinin (GNA); Narcissus pseudonarcissus agglutinin (NPA); Artocarpus integrifolia agglutinin (Jacalin); and mAb TM10 (IgM).
摘要翻译： 公开了用于探测前列腺癌细胞的免疫原性糖部分的方法。 该方法检测了在各种Gleason等级的前列腺癌中高度差异表达的糖基表位。 糖表位存在于前列腺细胞表面。 该方法还包括检测前列腺癌受试者中的自身抗体。 抗体结合通常是“神秘的”的N-聚糖的糖基序。 这个目标在前列腺癌中高度表达。 检测在前列腺癌组织中表达的这些糖表位的凝集素和抗体包括卫矛神经凝集素（EEL）; 茯苓四倍体凝集素-I（PTL-I）; Griffonia Simplicifolia果胶-I-A4（GSL-I-A4）; Griffonia Simplicifolia凝集素-I-B4（GSL-I-B4）; 黑曲霉I凝集素（SNA-1）; 菜豆提取物（PHA-L）; 山茱萸凝集素（GNA）; 水仙假水凝素（NPA）; Artocarpus integrifolia凝集素（Jacalin）; 和mAb TM10（IgM）。
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公开(公告)号：US5843785A
公开(公告)日：1998-12-01
申请号：US692826
申请日：1996-07-25
IPC分类号： G01N33/569 , G01N33/49
CPC分类号： G01N33/56988 , Y10S436/811
摘要： Glutathione levels are determined using a glutathione surrogate in HIV-positive patients to evaluate survival longevity and determine appropriate treatment. Low glutathione levels indicate a need for a glutathione enhancing supplement and a more aggressive therapeutic regimen, as well as diminishing drugs which may result in the reduction of available glutathione.
摘要翻译： 使用HIV阳性患者中的谷胱甘肽替代品测定谷胱甘肽水平，以评估存活寿命并确定适当的治疗。 低谷胱甘肽水平表明需要谷胱甘肽增强补充剂和更积极的治疗方案，以及减少可能导致可利用的谷胱甘肽减少的药物。
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公开(公告)号：US5607974A
公开(公告)日：1997-03-04
申请号：US180778
申请日：1994-01-10
IPC分类号： A61K31/195 , A61K31/198 , A61K31/52 , A61K31/70 , A61K38/00 , A61K38/18 , A61K38/19 , A61K38/22 , A61P31/12
CPC分类号： A61K31/70 , A61K31/195 , A61K31/52 , A61K38/00
摘要： Patients suffering from a pathological condition resulting in reduced intracellular cysteine levels are treated with a cysteine source capable of being transported to the cellular cytoplasm. Particularly, N-acetyl cysteine is employed in the treatment of AIDS patients.
摘要翻译： 患有导致细胞内半胱氨酸水平降低的病理状况的患者用能够被转运到细胞质的半胱氨酸源处理。 特别地，N-乙酰半胱氨酸用于治疗AIDS患者。
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公开(公告)号：US20090258792A1
公开(公告)日：2009-10-15
申请号：US12421964
申请日：2009-04-10
CPC分类号： C40B40/12 , C07K16/3069 , G01N33/57434 , G01N2333/42 , G01N2400/10
摘要： Disclosed are methods for probing the immunogenic sugar moieties of prostate cancer cells. The methods detect a number of glyco-epitopes that are highly and differentially expressed among prostate cancers of various Gleason grades. The glyco-epitopes exist on the surfaces of prostate cells. The methods also comprise the detection of autoantibodies in prostate cancer subjects. The antibodies bound to a glyco-motif of N-glycans that is normally “cryptic.” This target is highly expressed in prostate cancers. Lectins and antibodies that detect these glyco-epitopes that expressed in prostate cancer tissues include Euonymus europaeus lectin (EEL); Psophocarpus Tetragonolobus Lectin-I (PTL-I); Griffonia Simplicifolia Lectin-I-A4 (GSL-I-A4); Griffonia Simplicifolia Lectin-I-B4 (GSL-I-B4); Sambucus nigra I agglutinin (SNA-I; Phaseolus vulgaris-L (PHA-L; Galanthus nivalis agglutinin (GNA); Narcissus pseudonarcissus agglutinin (NPA); Artocarpus integrifolia agglutinin (Jacalin); and mAb TM10 (IgM).
摘要翻译： 公开了用于探测前列腺癌细胞的免疫原性糖部分的方法。 该方法检测了在各种Gleason等级的前列腺癌中高度差异表达的糖基表位。 糖表位存在于前列腺细胞表面。 该方法还包括检测前列腺癌受试者中的自身抗体。 抗体结合通常是“神秘的”的N-聚糖的糖基序。 这个目标在前列腺癌中高度表达。 检测在前列腺癌组织中表达的这些糖表位的凝集素和抗体包括卫矛神经凝集素（EEL）; 茯苓四倍体凝集素-I（PTL-I）; Griffonia Simplicifolia果胶-I-A4（GSL-I-A4）; Griffonia Simplicifolia凝集素-I-B4（GSL-I-B4）; 黑曲霉I凝集素（SNA-1）; 菜豆提取物（PHA-L）; 山茱萸凝集素（GNA）; 水仙假水凝素（NPA）; Artocarpus integrifolia凝集素（Jacalin）; 和mAb TM10（IgM）。
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9.发明授权公开(公告)号：US06566401B2
公开(公告)日：2003-05-20
申请号：US09833228
申请日：2001-04-11
IPC分类号： A61K31195
CPC分类号： A61K31/7072 , A61K31/198
摘要： The invention provides pharmaceutical compositions for the treatment or prevention of the toxic effects of therapeutic agents and methods of treating or preventing such toxicity using a toxicity reducing amount of N-acetylcysteine either alone or in combination with a therapeutically effective amount or, to achieve its therapeutic advantages, an amount larger than what is customarily given as a therapeutically effective amount, of a therapeutic agent. The invention also provides pharmaceutical compositions for the treatment or prevention of the toxic effects of therapeutic agents and methods of treating or preventing such toxicity using a toxicity reducing amount of N-acetylcysteine either alone or in combination with a therapeutically effective amount or, to achieve its therapeutic advantages, an amount larger than what is customarily given as a therapeutically effective amount, of a therapeutic agent whose side effects are made worse by increased oxidative stress or treatment related decreases in subject cysteine/glutathione levels or are otherwise relieved by administration of NAC.
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公开(公告)号：US5968755A
公开(公告)日：1999-10-19
申请号：US721260
申请日：1996-09-26
IPC分类号： G01N33/50 , G01N33/569 , G01N33/53
CPC分类号： G01N33/5008 , G01N33/505 , G01N33/5094 , G01N33/56972
摘要： A method of identifying an abnormal T-cell profile of an immunocompromised subject is disclosed. The method involves detecting the immunoreactivity of T-cells with at least two antibodies selectively reactive with naive T-cell surface proteins and comparing data from cells isolated from an immunocompromised subject with data from cells isolated form a non-immunocompromised subject. Also disclosed are methods of screening drugs or compounds for efficacy to stimulate the production of naive T cells in a subject.
摘要翻译： 公开了鉴定免疫受损受试者的异常T细胞谱的方法。 该方法包括用至少两种与初始T细胞表面蛋白质反应的抗体检测T细胞的免疫反应性，并将从免疫受损受试者分离的细胞的数据与从非免疫受损受试者分离的细胞的数据进行比较。 还公开了筛选药物或化合物用于刺激受试者中天真T细胞产生的功效的方法。
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