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公开(公告)号：US06897288B1
公开(公告)日：2005-05-24
申请号：US09692401
申请日：2000-10-19
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K2039/5154
摘要： The invention provides antigenic peptides derived from MAGE-A12 polypeptides and presented by HLA molecules. Methods for diagnosis and treatment which involve the polypeptides also are provided.
摘要翻译： 本发明提供了衍生自MAGE-A12多肽并由HLA分子呈递的抗原肽。 还提供了涉及多肽的诊断和治疗方法。
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2.发明授权Isolated, nucleic acid molecules which code for gage tumor rejection antigen, the tumor rejection antigen, and uses thereof 失效分离的编码计量肿瘤排斥抗原的核酸分子，肿瘤排斥抗原及其用途
公开(公告)号：US06013481A
公开(公告)日：2000-01-11
申请号：US669161
申请日：1996-06-24
IPC分类号： C12N15/09 , A61K38/00 , C07K7/00 , C07K14/47 , C07K14/82 , C12N1/15 , C12N1/19 , C12N5/10 , C12N15/00 , C12N15/12
CPC分类号： C07K14/4748 , A61K38/00
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as GAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described. Tumor rejection antigens are also shown.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为GAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为GAGE编码分子。 描述了编码序列和肿瘤排斥抗原及其前体分子的各种诊断和治疗用途。 还显示肿瘤排斥抗原。
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3.发明授权Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-3 and uses thereof 失效编码肿瘤排斥抗原前体MAGE-3的分离的核酸分子及其用途公开(公告)号：US06235525B1
公开(公告)日：2001-05-22
申请号：US08037230
申请日：1993-03-26
IPC分类号： C12N510
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , C07K14/4748
摘要： The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-3. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Uses of these materials in therapeutic and diagnostic contexts are also a part of the invention.
摘要翻译： 本发明涉及编码肿瘤排斥抗原前体MAGE-3的核酸分子。 还公开了利用核酸分子和任选的编码人白细胞抗原HLA-A1的分子的载体，细胞系等。 这些材料在治疗和诊断环境中的使用也是本发明的一部分。
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4.发明授权Method for determining head and neck squamous cell carcinomas, prostate carcinomas, and bladder tumors by assaying for mage-3 失效通过测定法师-3确定头颈鳞状细胞癌，前列腺癌和膀胱肿瘤的方法
公开(公告)号：US5512437A
公开(公告)日：1996-04-30
申请号：US204727
申请日：1994-03-01
申请人： Beatrice Gaugler , Thierry Boon-Falleur , Benoit van den Eynde , Etienne DePlaen , Francis Basseur , Bernard Lethe , Pierre van der Bruggen
发明人： Beatrice Gaugler , Thierry Boon-Falleur , Benoit van den Eynde , Etienne DePlaen , Francis Basseur , Bernard Lethe , Pierre van der Bruggen
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/158
摘要： A method for determining head and neck squamous cell carcinomas, bladder tumors and prostate carcinomas is described. The method involves assaying for expression of the gene coding for tumor rejection antigen precursor MAGE-3, or its expression product. Various assays, and kits useful for these assays, are described.
摘要翻译： 描述了确定头颈鳞状细胞癌，膀胱肿瘤和前列腺癌的方法。 该方法包括测定编码肿瘤排斥抗原前体MAGE-3或其表达产物的基因的表达。 描述了可用于这些测定的各种测定和试剂盒。
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5.发明授权Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-4 and 41 and uses thereof 失效编码肿瘤排斥抗原前体MAGE-4和41的分离的核酸分子及其用途公开(公告)号：US07199231B1
公开(公告)日：2007-04-03
申请号：US09579543
申请日：2000-05-26
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K16/30
摘要： The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-4 and 41. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Use of these materials in therapeutic and diagnostic contexts are also a part of the invention.
摘要翻译： 本发明涉及编码肿瘤排斥抗原前体MAGE-4和41的核酸分子。还公开了利用核酸分子和任选地编码人白细胞抗原HLA的分子的载体，细胞系等 -A1 在治疗和诊断环境中使用这些材料也是本发明的一部分。
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6.发明授权Methods for treating a disorder by using Mage-3 or Mage-3 related materials 失效使用Mage-3或Mage-3相关材料治疗病症的方法公开(公告)号：US06565857B1
公开(公告)日：2003-05-20
申请号：US09404026
申请日：1999-09-23
IPC分类号： A61K3900
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , C07K14/4748
摘要： The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-3. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Uses of these materials in therapeutic and diagnostic contexts are also a part of the invention.
摘要翻译： 本发明涉及编码肿瘤排斥抗原前体MAGE-3的核酸分子。 还公开了利用核酸分子和任选的编码人白细胞抗原HLA-A1的分子的载体，细胞系等。 这些材料在治疗和诊断环境中的使用也是本发明的一部分。
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7.发明授权Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-6 and uses thereof 失效编码肿瘤排斥抗原前体MAGE-6的分离的核酸分子及其用途公开(公告)号：US06946289B1
公开(公告)日：2005-09-20
申请号：US09583848
申请日：2000-05-31
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K16/30
摘要： The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-6. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Use of these materials in therapeutic and diagnostic contexts are also a part of the invention.
摘要翻译： 本发明涉及编码肿瘤排斥抗原前体MAGE-6的核酸分子。 还公开了利用核酸分子和任选的编码人白细胞抗原HLA-A1的分子的载体，细胞系等。 在治疗和诊断环境中使用这些材料也是本发明的一部分。
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8.发明授权Isolated peptides derived from the gage tumor rejection antigen precursor and uses thereof 失效衍生自量规肿瘤排斥抗原前体的分离的肽及其用途
公开(公告)号：US5858689A
公开(公告)日：1999-01-12
申请号：US531662
申请日：1995-09-21
IPC分类号： G01N33/48 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/525 , C12N15/09 , C12N15/12 , C12Q1/00 , C07K7/00
CPC分类号： C07K14/4748 , A61K38/00
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as GAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described. Tumor rejection antigens are also shown.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为GAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为GAGE编码分子。 描述了编码序列和肿瘤排斥抗原及其前体分子的各种诊断和治疗用途。 还显示肿瘤排斥抗原。
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